COVID-19 Update 63 with critical care specialist Roger Seheult, MD. Join Dr. Seheult for a live webcast, question and answer session, and free CME on Thursday, April 30 (4 PM EST): https://www.medcram.com/pages/covid-19-webinar
Dr. Seheult explains the theory that seems most plausible to us here at MedCram.com: That COVID-19 is primarily a disease of the endothelium (the single layer of cells that line blood and lymphatic vessels). This hypothesis helps explain the increase in cardiovascular complications from COVID-19: strokes, myocardial infarctions, thromboembolism (pulmonary embolism, DVTs, and other blood clots), as well as many critical patients who do not appear to have classic ARDS symptoms (and have relatively normal lung compliance etc. as observed by the research of Dr. Gattinoni in Italy and others). A deep understanding of this theory requires a review of some foundational biochemistry including the electron transport chain and ATP – the energy currency of the body.
Links referenced in this video:
MedCram Live Webcast – https://www.medcram.com/pages/covid-19-webinar
Johns Hopkins – https://coronavirus.jhu.edu/map.html
Worldometer – https://www.worldometers.info/coronavirus/
CDC and Lag Time – https://wwwnc.cdc.gov/eid/article/26/6/20-0320_article
American Journal of Physiology – https://journals.physiology.org/doi/full/10.1152/ajpheart.00331.2008
Some previous videos from this series (visit MedCram.com for the full series):
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress https://youtu.be/22Bn8jsGI54
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://youtu.be/fn2yk5SbGiw
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) https://youtu.be/NM2A2xNLWR4
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion) https://youtu.be/nO4xgcIaPeA
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
– Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
– Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?: https://youtu.be/kgzFAdYwYLM
– Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?: https://youtu.be/o8aG63yigjA
– Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: https://youtu.be/qc6VV7ue4cE
– Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: https://youtu.be/E7MufS6dnJw
– Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: https://youtu.be/fya6Zwxch88
– Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): https://youtu.be/uaIzj3s3p4A
– Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: https://youtu.be/JN-8bGB1cLM
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
Many other videos on COVID-19 (coronavirus outbreak, coronavirus symptoms, influenza, coronavirus epidemic, corona virus updates, coronavirus vaccine, boosting the immune system, vitamin D, vitamin C, Zinc, Quercetin, NAC, n-acetyl cysteine, Insomnia, PPE, hydroxychloroquine, ultrasound to diagnose COVID-19, coronavirus New York, COVID-19 and the epithelium/blood vessels) and other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com
Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at [email protected] if you are interested)
Media Contact: [email protected]
Media contact info: https://www.medcram.com/pages/media-contact
MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus
Join Dr. Seheult for a free live COVID-19 webinar and Q/A on Thursday, April 30 from 4 – 5:30 PM EST
Details: https://www.medcram.com/pages/covid-19-webinar
We made everything free for this event – including the CME. Please spread the word!
Thank you for visiting us at https://www.MedCram.com
At our website, browse all of our videos and CLEAR explanations of over 60 medical topics.
We also offer CME/CEUs for medical professionals, medical programs, and institutions.
All links referenced in this video are in the video description. Quick links to our previous updates on the coronavirus pandemic:
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress: https://youtu.be/22Bn8jsGI54
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://youtu.be/fn2yk5SbGiw
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC): https://youtu.be/NM2A2xNLWR4
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion): https://youtu.be/nO4xgcIaPeA
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
– Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
– Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing? https://youtu.be/kgzFAdYwYLM
– Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse? https://youtu.be/o8aG63yigjA
– Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: https://youtu.be/qc6VV7ue4cE
– Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: https://youtu.be/E7MufS6dnJw
– Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: https://youtu.be/fya6Zwxch88
– Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): https://youtu.be/uaIzj3s3p4A
– Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: https://youtu.be/JN-8bGB1cLM
– Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu: https://youtu.be/H1LHgyfPPQ8
– Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine: https://youtu.be/EFRwnhfWXxo
– Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention: https://youtu.be/G1zsE9_85i4
– Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful? https://youtu.be/A4eu-h_owaI
– Coronavirus Pandemic Update 43: Shortages, Immunity, & Can a TB Vaccine (BCG) Help Prevent COVID-19? https://youtu.be/LqKwAIIy-Mo
– Coronavirus Pandemic Update 42: Immunity to COVID-19 and is Reinfection Possible? https://youtu.be/q4P91VrfPGw
– Coronavirus Pandemic Update 41: Shelter In Place, FDA Investigates Hydroxychloroquine for COVID-19: https://youtu.be/hPz5KxgI_K4
– Coronavirus Pandemic Update 40: Ibuprofen and COVID-19 (are NSAIDs safe?), trials of HIV medications: https://youtu.be/dT6mHi_8V5E
– Coronavirus Pandemic Update 39: Rapid COVID-19 Spread with Mild or No Symptoms, More on Treatment: https://youtu.be/AToF8O5T86s
– Coronavirus Pandemic Update 38: How Hospitals & Clinics Can Prepare for COVID-19, Global Cases Surge: https://youtu.be/MoisrCTu0SY
– Coronavirus Pandemic Update 37: The ACE-2 Receptor – The Doorway to COVID-19 (ACE Inhibitors & ARBs): https://youtu.be/1vZDVbqRhyM
– Coronavirus Pandemic Update 36: Flatten The COVID-19 Curve, Social Distancing, Hospital Capacities: https://youtu.be/vww1nIIoqmw
– Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments: https://youtu.be/vE4_LsftNKM
– Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown: https://youtu.be/U7F1cnWup9M
– Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: https://youtu.be/Mm7UrZeu-74
– Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? https://youtu.be/Eeh054-Hx1U
– Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? https://youtu.be/7YI2tOoVVpk
– Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention: https://youtu.be/gmqgGwT6bw0
– Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran: https://youtu.be/XjEacUyp4vY
– Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate: https://youtu.be/quDYb_x54DM
– Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases: https://youtu.be/xQwfuJgJ9lo
– Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic? https://youtu.be/bV1CZxJ-uvU
– Coronavirus Epidemic Update 25: Vaccine Developments, Italy’s Response, and Mortality Rate Trends: https://youtu.be/UImSVhLLeGY
– Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms: https://youtu.be/wFoj2L2LpNA
– Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats: https://youtu.be/JGhwAGiAnJo
– Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing: https://youtu.be/OqpHvK0XADY
– Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?: https://youtu.be/9BYaywITXYk
– Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins: https://youtu.be/Ka48UZDDzLY
– Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials: https://youtu.be/4HK9QEy1KJ8
– Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips: https://youtu.be/vE4pBkslqS4
– Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19): https://youtu.be/wlbM6VVkVZM
– Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19): https://youtu.be/qqZYEgREuZ8
– Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19): https://youtu.be/o804wu5h_ms
– Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks: https://youtu.be/pDnmHu8x9C4
– Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada: https://youtu.be/0UgrPgJdzp0
– Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV: https://youtu.be/GT3_A1bf9pU
– Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine): https://youtu.be/pfGpdFNHoqQ
– Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV): https://youtu.be/gPwfiQgGsFo
– Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate: https://youtu.be/8Hjy3UfaTSc
– Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA: https://youtu.be/GpbUoLvpdCo
– Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding: https://youtu.be/nW3xqcGidpQ
– Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period: https://youtu.be/UGxgNebx1pg
– Coronavirus Update 5: Mortality Rate vs SARS / Influenza: https://youtu.be/MN9-UXsvPBY
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
– Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine: https://youtu.be/SJBYwUtB83o
– Coronavirus Symptoms, Diagnosis, Treatment: https://youtu.be/UCG3xqtcL3c
– Coronavirus Outbreak – Transmission & Updates: https://youtu.be/9vMXSkKLg2I
Beginning to crack the pathophysiology this virus leaves in its wake, is both complex and exciting. These discoveries may well carry over to the development of effective treatments for inflammatory autoimmune diseases as well.
It would be interesting to further examine the viral destructive actions on skeletal muscle, the gut, and nervous tissue next.
Amazing video today
Great, so free iron likely AND superoxide, this is just designed to do damage everywhere, yes I mean designed.
Why do you think that back in late 2019 Wikipedia suddenly slashed the case fatality rate for the 1918 Spanish Flu from 10-20% to 2-3%.
Dr.Seheult, I highly respect your expertise and I am really curious as to what your thoughts on Dr. Andrew Kaufman’s controversial statement regarding the virus. Thank you. -Charlene
https://youtu.be/6C_26ZIUlrQ
Life is so fragile. We exist on a knife’s edge of physics & chemistry. So many easy ways to create inadequate tissue perfusion in living systems. An absurd single point of failure.
I recall commenting a few weeks ago something along the lines of the thesis I am working on. You summed it up in this video sir.
Control the metabolism, you control the inflammation. Control the inflammation, you control the pain. Control the pain, you control the disease. And pain = any alteration of cellular/system homeostasis and signaling.
https://youtu.be/dsus3JvRZ_g
I literally explained this almost a month ago
Great video doc… I felt like I was back in med school!
Sepsis and COVID-19, both are endothelial diseases (blood vessel, clotting factors, thrombosis).
Dr Medcram – this explains why 85-90% of people on ventilators don’t leave the hospital alive.
“We’ll have to go back to medical school”? Never been there. Thanks Dr Medcram for making me smarter!
Very interesting…..ace2 is so important to stop super oxide that stops oxidative stress so the main thing is to stop the virus binds ace2 or attracting ace2
Superb. Thank you so much
Awesome job explaining this. Thanks.
Wonderful lecture. So is “SARS” a misnomer?
Wow! I had to watch this twice but I think I got the gist of it. This is truly mind boggling to see this complexity, and you’re an excellent teacher.
Wow! This lecture helped me to finally start grasping the entire process of the mitochondria. Finally all those pieces fell into place.
But I still couldn’t tell you the technical terms, yet.
Great fuckin job Doc.
Wow. There’s some much stuff going on in the human body at all times.
Doctor, again thank you for all your insights! I am not in the medical field but I like to stay informed and this is just great.
I cannot recommend it enough.
Blood borne fungal infection…
Why are these doctors so incompetent to reality.
Your circulating acid in the blood..just by clogging up the circulation system.
Alfatoxins, acid secretion… virus, vector.. to doctors infinite wisdom is just based on size…
Cure is baking soda and vitamin C…
Hahahaha.. I explained this a month ago…hahahahahhahaha.
Not a medical Professional, but I’m interested in these presentations. Thank you for sharing. 👍
If this correlation was so, wouldnt we see as a byproduct of the deregulation of superoxide production by reduction in ANG-1,7, that the viral load within the lungs and endothelial cells would drasically and rapidly reduce from the super oxides similar to the super oxidative bursts produced by macrophages? If not also a mass reduction in the viral load systemically along with the oxidative stress damage purposed to be responsible for the mortality?
So equatorial countries should see the greatest static plateau, lending credence to UV concentrations being our greatest ally against SARS-CoV-2….yet no one has shut down the NYC subway. Any surprise that a massive public transport system devoid of UV promulgated the highest mortality?
I have very little knowledge in this field but its just really amazing the amount of learning i gained during watching these series of presentations. Truly appreciate it
AWESOME explanation!! Thank you 🙏
I might be wrong but you said in an old video that smoking can cause to generate more ACE2. Should it will be better to increase smoking? I typically smoke 20 cigarettes a day. But reduced it 8 now a days.
DOC PLEASE READ – THIS COULD POTENTIALLY HELP SAVE LIVES:
Vitamin C mixed with Organic Folate. Simple vitamins, perhaps can help you outrun the viral infection? Think “conversion”. Study the chemical formulas when they are mixed together coming off of cellular conversion properties. The virus attaches itself to red blood cells. Once it begins to invade the RBC, it removes the iron component from it’s hemostasis. The Iron FE2, is converted into FE3 in blood cells and it remains in hemostasis which allows the RBCs to transport oxygen. Without iron in it’s hemostasis, the RBC loses it’s ability to transport oxygen, thus causing hypoxia.
Folate creates red and white blood cells in the bone marrow and vitamin C only assists it to adhere to the cellular matrix of the RBC. Taking vitamin C with folate helps because of the viral ‘conversion’ process when it infects the cells, cannot override the nitrogen component – which causes the virus to go into a stand still and dissipate.
Organic folate can only be consumed from the foods we eat. Our bodies cannot naturally produce folate. Thus the need for a conversion process. This could help boost our immunity against the virus.
Who would have thunk it that my college biology classes from 40 years back might now save my life! Still remember it today on a test we had to work out the chemical reaction which takes place as part of the Krebs Cycle! Still remember most of that today! The mitochondria is a fascinating structure! However the sad part is I asked my pulmonologist about the Krebs Cycle he would look at me like I had a third eye!
What about anakinra to help those patients who are in cytokine storm?
https://www.medpagetoday.com/rheumatology/generalrheumatology/82198
Thanks
You should lecture all the world’s leaders (allthough probably 95% doesn’t understand what you are talking about😂)
Wow! Thank you so much for explaining such complicated systems in such a clear fashion!
1000’s of deaths caused by vents. Wonder when they will stop killing people with them… Maybe you could mention a word about this down the road.
So everything from a runny nose to a pneumonia from cancer to Kawasaki from obesity to blood clots, LET’S KEEP ALL FAST FOOD OPEN
Hi. I have one question. Around the world, vaccines are being developed for COVID-19 thinking it is a respiratory virus. Now with this new finding that it is kind of blood disease, are they still on right track or they have to start from scratch with a new approach.
So how do you protect a patient in need of a cerebral angiogram against infection of Covid 19? Is a high immune system enough?
Dr Fauci’s a fraud and medical corruption go to Former:aids scientist exposes Dr Fauci’s medical corruption. It’s not just the coronavirius there is another virus mixed with it and still labeled it coronavirius so nobody would no what the other virus is. Special when they burn all the body’s Dr Fauci’s funded coronavirius study’s in Wuhan China. U must watch this.
Epic explanation. 👍
This Doctor needs to run the WHO, he is on top of everything! Lets put an expert who is in everyday practice in charge. Some one that is on it, everyday! Not some incompetent bureaucrat sitting in an ivory tower far removed from the real World. Dr. Seheult is my Man of the Year! He loves medicine, I can tell!
So does this mean that all the peanut M&Ms that I’m eating are a good thing? (Thought we could all use a bit of humor).
👍🏻🇺🇸👊🏻 Your eyes are open.
BCG vaccines shown direct effect on Type I Diabetes https://youtu.be/9x_o6B_UnDY
I am so glad to have found this channel. I look forward to the end of the story. This virus is exploiting the poor metabolic health found by nearly 89% of Americans. I fear our deaths will be higher than other countries because of our sugary, grain/pasta, highly processed seed oil diet.
Could therapies targeted at mitigating oxidative stress be the key to treating COVID-19 until a proven vaccine is developed? Such fascinating work. Many thanks to Dr. Seheult and others like him who are unlocking the pathological secrets of COVID-19.
I think possibly
Wow! Thank you!
Thank you again! You are a genius and it’s very nice to watch you videos. The way you explain is even understood by younger teenagers who like to become doctors in the future.
Thank you
Nattokinase dissolves virus envelope and thins blood and dissolves blood clots could that help?
The story of my life — she is ready to give it up and I am ready to accept it 😀
Love your channel. Like a khan academy but relevant.
Great understandable presentation. You really explain so most people (me) can follow. So thanks and i look forward to YOUR next presentation 😎✌
Superoxide dismutase[edit] https://en.wikipedia.org/wiki/Metalloprotein – here’s the importance of copper and zinc
Structure of a human superoxide dismutase 2 tetramer
The superoxide ion, O−
2 is generated in biological systems by reduction of molecular oxygen. It has an unpaired electron, so it behaves as a free radical. It is a powerful oxidizing agent. These properties render the superoxide ion very toxic and are deployed to advantage by phagocytes to kill invading microorganisms. Otherwise, the superoxide ion must be destroyed before it does unwanted damage in a cell. The superoxide dismutase enzymes perform this function very efficiently.[32]
The formal oxidation state of the oxygen atoms is −1⁄2. In solutions at neutral pH, the superoxide ion disproportionates to molecular oxygen and hydrogen peroxide.
2 O−
2 + 2 H+ → O2 + H2O2
In biology this type of reaction is called a dismutation reaction. It involves both oxidation and reduction of superoxide ions. The superoxide dismutase (SOD) group of enzymes increase the rate of reaction to near the diffusion-limited rate.[33] The key to the action of these enzymes is a metal ion with variable oxidation state that can act either as an oxidizing agent or as a reducing agent.
Oxidation: M(n+1)+ + O−
2 → Mn+ + O2
Reduction: Mn+ + O−
2 + 2 H+ → M(n+1)+ + H2O2.
In human SOD the active metal is copper, as Cu(II) or Cu(I), coordinated tetrahedrally by four histidine residues. This enzyme also contains zinc ions for stabilization and is activated by copper chaperone for superoxide dismutase (CCS). Other isozymes may contain iron, manganese or nickel….
Thank you Doctor! I kinda understood what you were talking about and where it took us. Thank you for your research into this virus and helping us to understand also. Very interesting and very valuable.
Could this effect someone with homocysteinemia who had a pulmonary embolism one year ago?
Did the original SARS virus also caused the same endothelium damage, as it also bound to ACE2?
thank you !!!
Excellent lecture. None of my professors can match your command of the subject
Blood vessels and clots? Cardamom, curcumin, garlic all been shown to reduce blood clots as well as exhibiting antiviral capacities (more so in vitro of course) but how would dietary changes fit in? Looking at worldometers table India, Thailand (where turmeric, cardamom, garlic are common in food) have rather low deaths/1m population….coincidental misrepresented reporting or?? Beetroot powder/juice?
I wonder if homozgous mthfr mutation would make things worse?
Where does selenium play a role in the Glutathione cycle?
Absolutely masterful work!
Melatonin is endothelium protective, boosts the body’s natural antioxidant system such catalase,SOD and glutathione, is a highly potent antioxidant on its own, is protective of mitochondria and mitochondria activity, increases ATP production, helps prevent reduction of ANG 1,7 and is a potent antiinflammatory among many other potential health benefits! Please do a report on melatonin as it might relate to Covid-19!
Could dietary creatine affect this cycle
👏👏👏 thanks! Perfect explanation
I’m covid positive and 22 what can I do to prevent this
HBH786 relax and takes supplements that the Dr takes. Another video. Do breathwork and dont eat any junk
Dr. Seheult, I am grateful for your efforts. I’ve never been to med school, so this is all a stretch for me. But the lucidity of your explanations is, perhaps, without comparison. You and your colleagues are doing wonderful work. I am thankful. Do, please, be careful in your ICU. Wouldn’t want to lose you.
Amazing to be able to explain something so complex so simply and clearly, kudos!!
Been following your updates for quite a few weeks now . Health care assistant in a Nursing Home . Totally lost now ! It’s getting too complicated for me now , I only have NVQ 3 training. This is not a complaint 👍 I just don’t understand quite a lot of this 😶 Too advanced for me . Will Google stuff ! Thanks for your updates , really appreciate your updates , trying very hard to understand all the information. Thankyou . At the moment we are Covid free 👍 Thanks for all you are doing to keep us informed . 👍♥️
we (our cells) are sooooo complicated.
Wow!!! This is way more believable than the presentations I’ve seen trying to explain why 5G causes COVID 19…haha…. Amazing how you’re able to break down complex medical subjects in terms that everyone can digest. Awesome!!!!
Dr. Seheult I want to thank you so much for all the effort you put into these videos, and obviously your contribution in fight against Covid-19. Amazing, how you can make such complex topics seem relatively easy to understand for all of us who are not medical professionals. I have learned so much from your videos in the last couple of months.
On the topic of the video, I was thinking about the previous SARS viruses, as they also used ACE II as an entry point into the cells. It would be interesting if one could get his hands on the medical data of original SARS and MERS patients, especially their blood-work results and compare them in a much more focused way to the current Covid-19 patients.
Any antigen that is using ACE II to bind, could potentially have the same effects on the human body, only the back then these symptoms might have been completely missed.
Looking forward to the next video, quite excited to hear new information about this topic.
Stay safe, and keep up the good work 🙂
Thank you Doctor Seheult for the immense work you are putting into assembling all this information in a digestible form, ON TOP of your full-time job fighting this horror at the point it is most desperate.
I’m simply soaking up these postgrad level studies right on the leading edge of biochemistry and the mechanisms of infection and damage from a disease, which you selflessly provide free to us and the whole world.
I’m miraculously managing to follow them, despite a background (In IT, so at least I’m used to logical thought and ongoing education) far removed from the medical field (although I’ve always been science nut, a trait inherited from my grandfather).
The closest I’ve ever been to studying medicine was understanding my own sicknesses and treatments (unfortunately many and varied), basic first aid (I used to do voluntary work as a motorcycle road race marshal, so have been the available body to assist in some trauma management) and studying for my flying exams. You manage to explain in ways which simplify the complex and even allow me to make predictions of the direction this is leading in. I may be smart (my medical records say I am), but without an explanation presented logically, I’m lost! I think there are probably far more smart people out there who simply have not been given the chance to show it than is commonly believed.
You are providing that logical explanation, and in a way that even those outside the medical field can follow!
Definitely worthy of the Faraday prize, and if and when it is turned into a paper for peer review and published (which it should be – you are making logical steps which tie so many other papers together and then apply them in a new way), it could easily become the definitive text on how to manage and treat the virus effectively, and be worthy of the Nobel prize for medicine, given the global desperation for such a management protocol.
But first we’ve got to beat this little bastard of a virus, and thank you for your work in the trenches actually applying all this to those who need it most.
Bottom line: You don’t want this damned bug. It ain’t the flu.
Excellent crystal clear presentation providing cutting edge understanding of a novel coronavirus. Clearly understood with just ‘A’ Level biology studied 45 years ago!! Thanks much Dr. Seheult for your unstinting labour of love.Cheers
Why do you need to invoke this complex oxidative stress mechanism? Wouldn’t a simpler mechanism be
1 virus infects vascular endothelial cells through ACE-2 receptors
2 immune system destroys infected cells creating breaches in membrane
3 underlying VWF leaks into the bloodstream triggering clots
The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial: https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-020-0518-7
Dr Seheult here is another deep dive: New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis https://www.hindawi.com/journals/ijhy/2012/147825/
Are any other Zinc ionophores such as Quercetin likely to be as effective as Hydroxychloroquine as ionophores for Zinc, if various politicians, State Governors, etc, make HCQ hard to get?
eg. “Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate”
https://pubs.acs.org/doi/10.1021/jf5014633
I don’t know why we keep reporting the actual number of cases it’s the percentage that really matters
And people still think we came out of primordial ooze. Right.
That was fascinating and really well explained, I look forward to hearing about the next steps (even if I’m unable to attend the live webinar)
Always informative and understandable – thank you.
God bless and protect you DOCTOR
Shouldn’t these elevated superoxides be visible in a blood analysis?
This particular lecture will go down in history as one of his best. So great!
I hope you will touch on the Glycocalyx topic next.
https://youtu.be/ZqusAww2mdo
Very interesting at all levels. Keep up the good work! As an electrical engineer, we keep digging till we have “root Cause” for a problem, there always is one. It is just a matter of finding it. If you have a fix without knowing root cause, you are likely to be disappointed in the future.
Extraordinary!!!!!!
Hi on 15:12 when explaining the oxidation process, it seemed to me that it is not the addition of electrons but removal of electrons or addition of protons.
Very clear explanation even ordinary person like me understands it.
I never could understand Krebs cycle
Thanks so much<3 .... I know this is a late question but... does it matter if air is cold or hot with pneumonia etc?? does it change the thickness of liquid in lungs etc? does it make it easier to cough up mucus etc if its cold or make it viscus with warm air???
thanks for giving me hope with light, in a dark fucked up cave lol <3 I send you strength, patience, and hope <3
Gloworm Sparkle far colder air hurts with pneumonia. However warm humid air feels better. Mustard or onion packs are good for pneumonia and a good heating pad. Breathing exercises help cough up mucus plus a good expectorant Must keep moving. Not too much laying about
Incredible connecting the dots here! I recall a fellow stuent (we’re talking 1980’s college!) doing independent research on superoxide dismutase as he believed it was a critical player in causing/preventing serious disease. He thought selenium was involved, I don’t know how his research work came out unfortunately.
Dr Seheult – here is a deep dive (way over my head) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939482/ “This review discusses the transcriptional and post-transcriptional regulation of ACE2 and the role of the ACE2/Ang 1–7 axis in cardiac physiology and in the pathophysiology of heart failure. The pharmacological and therapeutic potential of enhancing ACE2/Ang 1–7 action as a novel therapy for heart failure is highlighted.”
“The difference in ACE and ACE2 enzymatic activity became more evident upon the discovery that human ACE2 catalytic efficiency is 400-fold higher with Ang II as a substrate than with Ang I.38, 42 To further unravel the biological role and importance of ACE2, several ACE2 inhibitors were designed and synthesized via substrate-based43 and structure-based44 pharmacophore design and virtual screening. MLN-4760, a potent and selective inhibitor developed with substrate-based design, has been a key tool for in vivo and in vitro studies.43 In the last 15 years, distinct roles of ACE2 have been discovered ranging from catalytic activities with various substrates, functional SARS coronavirus receptor, and an amino acid transporter.34, 40, 45, 46 ACE2 was initially thought to be expressed only in heart, kidney, and testes,33 but was eventually found to be widely expressed in various organ systems including the cardiovascular system, kidneys, lungs, and brain, in which it exerts important actions to maintain cardiovascular homeostasis.47–52 In the heart, ACE2 is localized to cardiomyocytes (contracting cardiac muscle cells), cardiac fibroblasts, and the coronary vascular endothelium.53, 54 MasR is also present on cardiomyocytes, cardiac fibroblasts, and endothelial cells.19, 55–57
Blood filter time?
Bio sciences are not my expertise (I’m an engineer), but your explanations are cristal clear even for me.
Thank you.
Hi guys! Any hint if/how angiotensin II receptor antagonists (e.g. Valsartan) would be beneficial in this context?
I was told by doctors that COVID-19 is a respiratory illness. Do you disagree Doctor? https://www.youtube.com/watch?v=okg7uq_HrhQ
You Nail It!
Dr. Seheult what you are doing is extremely important in this difficult time. It reassures people who are not in the field, people who are frustrated, people around the world who lost hope. Your videos inform your peers and inspire students and other researchers.I vote that this community as well as specialists recognize you as one of, and possibly the champion of the fight against this terrible pandemic. I adore your way of pulling scientific papers and creating conversations between your observations your interpretations, and the work of others that already went through peer reviews. Your discussions make a lot of sense. You always keep a small margin of doubt until you verify the idea. That is the way excellent scientists follow. Please continue this good work.
Amazing effort thanks is not enough
Look for sildenafil studies coming up soon. Viagra may help in the treatment protocol.
What does this imply about ACE II antagonists?
One thing for sure. This virus is super smart.
Brilliant video thanks
Doc , study from Taiwan show people who had BCG Vaccination are lower their risk to Covid 19.
Excellent video. Are there other diseases which also cause superoxides to form? If so, do we have any treatments which can be used to help the body remove these superoxides?
Dr Seheult, I don’t understand this but I think it would fit into your line of thought — https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000209020.69734.73 “A lot can be learned by comparing the efficiency by which a given angiotensin peptide is converted by the various pathways: Rice et al6 recently carried out such a systematic study comparing the binding affinities and cleavage efficiencies of ACE, ACE2, and neutral endopeptidase (NEP) for Ang I, Ang II, Ang 1-7, and Ang 1–9. The first thing that is striking is that the affinity of Ang II for its receptors is about a thousand times higher than its affinity for the ACE2 protease that will convert it to Ang 1-7 (Table). What this means is that long before there would be enough Ang II to fuel the generation of the supposedly vasodilatory Ang 1-7 through ACE2, the vasoconstrictive AT1 receptor would be saturated. However, there are 2 ways around this seeming conundrum. First, if the AT1 receptor were blocked (eg, by an angiotensin receptor blocker [ARB]), Ang II would accumulate and could be converted to Ang 1-7 without stimulating the AT1 receptor. In fact, Ang 1-7 levels have been reported to increase by as much as 25-fold after either ACE inhibition or ARB treatment,7 supposedly by using either the NEP or ACE2 pathways, respectively (see Figure 1). The second solution to this puzzle might be that the processing proteases and receptors are in different tissue compartments. Crackower et al8 demonstrated recently that ACE2 is particularly enriched in the coronary vasculature where it appears to play a key role in Ang 1-7 generation. Using human transplant hearts, Zisman et al9 showed that intracoronary infusion of [123I]-labeled Ang I led to efficient production of labeled Ang II and Ang 1-7 in the coronary circulation, both of which decreased in parallel (by >10-fold) when the infusions included an ACE inhibitor. These results suggest that the preferred pathway of Ang 1-7 synthesis in the coronary circulation is via Ang II and ACE2. However, Ang II receptors are abundant and functionally important on both vascular endothelial and smooth muscle cells. For these reasons, it seems likely that Ang 1-7 biology will be most important when inhibitors of the RAS are being used.” https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000209020.69734.73
Wow. That was alot to digest. What does Co Q 10 do to these systems?
OUTSTANDING presentation Dr. Seheult! You always do a marvelous job but you knocked this one out of the park! Clear, concise and easily understood! Looking forward to the next in this series.
After this discussion, the importance of NAD+ is clear.
What are your thoughts on reducing ACE-i doses for SARS-COV2 patients with HTN? Great presentation by the way. I’m taking my medical boards in a couple months and this was a great refresher!
Now that I understand the language? Not even close but he explains it in a way where I can see the outline. Omg… dr. Seheult is amazing! Why is he not on every news channel!!! What is wrong with this world where we have to be fed dr. Oz instead of de. Seheult??!!
This was a lot of good information for a layperson like me. Seems we need something to protect Ace 2 before it impacts the rest of the process. Of course i know nothing, but I appreciate these lessons.
How about Aliskirnen(renin inhibitor) to reduce Angiotensin 1 and thus Angiotensin 2
Another great video! I watched an oral history of a woman that lived through the 1918 flu. She said that her family was the only family not infected in her town. She credits her family’s health due to taking a teaspoon of baking soda in a glass of water every morning. I am wondering if there is anything to that? I found an article in JAMA on the topic. https://jamanetwork.com/journals/jama/article-abstract/219523
Outstanding info. Thanks!
Undoubtably the best explanation of the moving picture of Covid 19. Thank you for keeping all of us informed.
The human body and it’s detailed function is truly amazing.
we skipped organic and went straight to bio….. thank you for the oxidation reduction and Krebs cycle explanation
Wow. I had to put my 2 biology semesters from college to work. Came useful in understanding what was being spoken about. Thanks so much for this lesson. This is a beast of a virus.
Glutathione is the body’s antioxidant
Ok- is there some way to create angiotensin 1,7? Can our own pleuro stem cells be used? Is there a way to monitor how much we have or need in real time? Sorry, stupid questions.
I’ve never paid more attention in my life. This is more exciting than any episode of The Wire.
Excellent, but now I feel less of a human being & more like a walking can of chemical soup.
I wish I could remember where I read it/who wrote it, but it was something to the effect of – if the answer to the virus rests in the kreb’s cycle and ETC, I’m going piss myself – as they hated learning it & guess brings back bad memories. Made me think back to grad school where I can still visualize my drawing of the cycle & ETC in my notebook. Good times, good memories for me at least. Thanks again for all of your hard work – I love your channel!
Thanks for your update 👍
Question- Is it possible that patients taking ACE inhibitors are more reactive to COVID? I heard this was a possibility.. THANKS
Long suspense. But after the crash course in Oxidative Phosphorylation and the introduction of ROS’s the last part about the inhibition of NADPH oxidase is particularly enlightening. Thx. Waiting for part 2.
A wealth of information here! Allow me to suggest adopting a low inflammation diet; ‘VLC’, ‘LCHF’, ‘Ketogenic’ diets. ‘Low carb down under’ has a rich youtube channel as well (also replete with lectures from esteemed / learned doctors, MD’s, physicians and researchers) (no affiliation). My motto; if it’s green, or it breaths, I’ll eat it. Good health, all!
You are doing absolutely great work, Doc. I am not a medical student nor am I a doctor, but I thoroughly enjoy your videos and even as a layman I am understanding things. I am hoping you’re on to something. Keep up the brilliant work
Nice job!
Wow this is very interesting
α-Ketoglutarate (AKG) can act as an antioxidant both in vitro and in vivo. However, the mechanisms of the protective effects of AKG are still not well understood. We evaluated the effects of AKG supplementation on the regulation of the constitutive-androstane-receptor (CAR) pathway in porcine intestinal cells and piglets exposed to H2O2. Our data showed that AKG treatment significantly increased not only the intra- and extracellular levels of AKG (26.9 ± 1.31 μmol/g protein, 1064.4 ± 39.80 μmol/L medium) but also those of Asp (29.3 ± 0.21 μmol/g, 4.20 ± 0.11 μmol/L), Gln (24.82 ± 1.50 μmol/g, 1087.80 ± 16.10 μmol/L), and Glu (91.90 ± 3.6 μmol/g, 19.76 ± 1.00 μmol/L). There was approximately a 4-fold increase in α-ketoglutarate dehydrogenase mRNA levels in enterocytes and a simultaneous reduction in ROS levels (P < 0.05). Moreover, AKG treatment increased the activities of the antioxidant enzymes and the efficiency of cellular respiration (P < 0.05). AKG also regulated the mRNA levels of the target genes involved in antioxidant responses and xenobiotic detoxification in enterocytes. Increases in the protein levels of SOD1, SOD2, CAR, RXRα, and UCP2 and marked reductions in the expression levels of Nrf2 and Keap1 proteins (P < 0.05) were observed after AKG administration in the H2O2-induced piglets. Our results indicated that AKG may protect against oxidative stress by activating CAR signaling and modulating the expression of key antioxidant-related targets, which improves cellular respiration and antioxidant capacity. The in vivo and in vitro effects of AKG suggest that it may prove to be useful in the reduction of oxidative stress in animal and human trials...
That was a great refresher! NADH and Electron Transport Chain brought back memories of med school. Also great theory, can help refine therapeutics. Mind is abuzz with ideas.
Nutritional ketosis, paleo, intermittent fasting all help to reduce oxidative stress.
It is like watching a great detective discussing a murder scene. Great info. I have been Ketogenic for 4 years and have not been sick. Yes, an N=1 but lots of data that Keto reduces ROS and CRP (inflammation). Hmmm I wonder if my diet has been protecting me??
I’ve been carnivore and I wonder that too
Great video, doctor. The first time I learned about glutathione was from Dr. Mark Hyman. His video is still on YT https://youtu.be/Eh2PYQBICWs (Glutathione: the “mother” of all antioxidants”. Take a look when you have a chance. Thank you for these updates. I’m learning a lot about this nasty virus.
Everyone in my town is treating Covid as if its fully gone now. Last week everyone was social distancing, wearing gloves & masks, and all businesses closed. Now as of monday dverything is back to “normal” now you see 1 in 15 people actually wearing ppe and they get looks. Im one of them.
So the oxygen gets turned into water, just thinking about that process kinda baffles me , I mean water , and what about low doses of peroxide
Zinc is required for the activity of > 300 enzymes, covering all six classes of enzymes
https://www.sciencedirect.com/topics/medicine-and-dentistry/angiotensin-converting-enzyme-2
Zinc is the metalloenzyme of the Ace2 cell. Sars-cov 2003 and several species bind away the zinc from the cell deactivating the zinc metalloenzyme activity. This has many downstream effects. Ace2 cells are found throughout the body including the skin. We are just seeing the beginning.
Wow!
I am loving these lectures. I was hurt in a car accident and do to poor diet and bad habits my auto imune system was damaged and I recieved head and neck injuries. I seen lots of doctors and only got worse so I started to treat what I could my self It was very hard as I could hardly think from the pain. But thanks to WebMd and many medical schools online I learned about autoimune and managed to get my health mostly working again.
I dont see fungus mentioned much and Id like to point fingers at fungus it causes all kinds of weakness in the body and their may need to be some consideration into it and covid19 as fungus can weaken us in many ways.
I became facinated by how everything works in the body and am loving these lectures expecially todays this really brings light on why autu-imune can cause so much damage.
Can that fact the Vit D plays a roll in regulating Renin and Angiotensin I. Basically meaning that the body runs out of Vitamin D faster at people who are infected by Covid19? if that’s the case, it makes a lot of sense to load up on those IU.. 4000IU should probably be a minimum recommended intake, not the minimum these days.
https://www.ahajournals.org/doi/pdf/10.1161/JAHA.114.001417
Wow this one was pretty complicated compared to the past several ones but it’s very interesting and educational. thank you!
Brilliant!
“Free radicals, antioxidants and functional foods: Impact on human health” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/
What about Hydroxytyrosol suppliments made from the leaves and fruit of Olives, it’s apparently the strongest natural antioxidant.
Could it be used as a preventative measure or early treatment of symptoms? I’m going to start eating more antioxidant rich fruits and vegetables from now on.
oxidized = discharge, reduced = charged. OMG. This industry is a joke. Hi, I am an industry trained MD, I research a PDR. I offer no cures but I do offer chemicals that will suppress your symptoms.
Dr Seheult I was looking again at the function of NAC supplements and I ran across this related paper on your topic here. Wondering your thoughts? Thank you!
“Curcumin induced oxidative stress attenuation by N-acetylcysteine co-treatment: a fibroblast and epithelial cell in-vitro study in idiopathic pulmonary fibrosis”
https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0096-z
I’ve been taking both for many years
wow, you deserve a medal for how much time and effort you put into these videos!
The randomized, double-blinded, placebo controlled trial of remdesivir, put out by The Lancet was published today…
– “Our trial found that intravenous remdesivir did not significantly improve the time to clinical improvement, mortality, or time to clearance of virus in patients with serious COVID-19 compared with placebo.
– “Remdesivir did not result in significant reductions in SARS-CoV-2 RNA loads or detectability in upper respiratory tract or sputum specimens in this study despite showing strong antiviral effects in preclinical models of infection with coronaviruses.”
Yet, the NIH also announced today “NIH Clinical Trial Shows Remdesivir Accelerates Recovery from Advanced COVID-19”
Though the p-value was not statistically significant? Thoughts? Or maybe I should save my question for the webinar….
https://www.niaid.nih.gov/news-events/nih-clinical-trial-remdesivir-treat-covid-19-begins
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31022-9/fulltext?fbclid=IwAR1ijUE1Droj0mmAQfgEmFY_l3I6PkV-2vXVKdVebNR57VnZ43E4Wj-ilF0#seccestitle160
Why do we need biochemistry? Dietary fat and cholesterol – NOT CARBS – adheres to the endothelium, causing plaques. Adipose inflammation of ACE2 is referenced in many research articles on diabetes. If you have obesity, type2 diabetes or hypertension, it’s because there is too much fat in your diet. Cut out the meat, dairy, eggs and oil, and replace them with potatoes, rice, beans and vegetables. Problem solved. I am convinced that the reason the mechanics of this disease are taking so long for the medical community to understand is that so many professionals are clueless about nutrition. You bring up the example of gas in the car – carbs are unleaded and fat is diesel. Our body is an unleaded engine, and excess fat shuts the whole system down. In the case of Covid-19, the fat deposits in your vessels leave you proportionately vulnerable to systemic endotheliitis.
@Douglas A Macary Low carb diets restrict calories, which reduces body fat, which makes you feel better for a while. They are not sustainable, natural or healthy, and they do not reverse vascular disease. Dr. Neal Barnard.
Dr. Jason Fung
I been hearing about videos surfacing about smokers being immune because of the lining of the lungs being coated in tar , your thought please
Well it seems that many of the people dying were smokers, in comparison to others who also had it & were hospitalized. Can’t remember, which session he talked about it , it was early on.
LEO / GER
QUESTION: Has anyone in China examined the pathology of this virus and its presence in bats?
Thank you Dr. Seheault, I am a student teacher, would you be able to provide me a link or a resource, so I can learn how to diagram and create flow charts like you, and incorporate visuals in my teaching like you, for the benefit of my future students. I would really appreciate it.
you are the best of teachers!! thank you for explaining for us everyday folk
Great video! Some questions came up: If ACE inhibitors do not only block the conversion of angiotensin I to angiotensin II, but also the conversion of angiotensin 1-9 to angiotensin 1-7, would this mean that ACE inhibitors could have a counterproductive effect in terms of increasing oxidative stress by reducing the available angiotensin 1-7? Since vitamin D (Calcitriol) inhibits the expression of renin, which in turn converts AGT to angiotensin I, what would be the expected downstream effect of vitamin D supplementation in terms of angiotensin 1-7 alterations (if both angiotensin II and angiotensin 1-9 levels decrease)?
No medicine school for me, conchology is my cup of tea. But I can just follow it. Very good.
“…which leads the patient into a situation known as”…SOL.
Once the virus enters the lungs and takes out ACE2, it’s really a house of cards of organ failure.
But there’s potentially good news on the horizon…
This is the BEST NEWS I’ve heard in a while. It looks like the Oxford UK Group who after 15+ years developed and tested a vaccine for the Coronavirus MERS a cousin to COVID-19. Has tweaked the vaccine enough that the test just concluded at the US National Institue of Health Lab in Hamilton, Montana USA…was shown to be a success. So they are now starting human trials with thousands of volunteers. If this works we could have a vaccine being produced in the US and India in great volume starting September.
In preparation, they have already produced a million vaccines that will be given out the second there’s a positive result from the trial is known. They are using a tried and tested method to develop this vaccine so it should be a success.https://www.youtube.com/watch?v=vlHsZOE6Evg
Hope it’s nothing to do with Gates and his cronies.
I’ve read that there have been instances of high iron concentration in the bodies of patients suffering from Covid19. Can this be that because of impairment of the SOD function via the lack of ANG 1-7, Catalase is the only mitigating factor in combating Oxidative Stress? Thus, the high iron levels due to Catalase being the only game in town, so to speak. I’m a retired truck driver, so you all go easy. It’s truly a credit to Dr. Seheult’s concise and thorough presentation that allows a layman such as myself to comprehend the insidious nature of this disease. I’m looking forward to the Webinar tomorrow. I’ll be the old, quiet guy in the back row. Cheers!
Moe Beddah Hey, Moe, save me a seat. We can swap old timie trucking stories after class.
Thank you Dr Seheult for your generosity. God bless you
~Much love❤❤❤~
Would this be why iv vitamin c is supposed to help 🤔
And interestingly quercetin is an antioxidant and anti-inflammatory. There are various articles on the beneficial effects in vitro and in vivo of quercetin over endothelial cells, here is one:
Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols.
https://www.ncbi.nlm.nih.gov/pubmed/17015250
André Balsa took loads when i was sick. Also use it now as allergy season starting. Have used it for allergies for years
What are your thoughts on an nebulized antiviral? Or nebulized Ivermectin
I wouldn’t nebulize Ivermectin. I have taken it orally. You can nebulize Glutathione.
The mitochondria is bus for the 3 values Carbs /prot/fat ….being on Keto diet where the intake of fat burns as a cleaner fuel source , Fat 80% protein 20% carbs at 5%, how does this affect
O2 and H2o ?
I also have utilized you lecture 37 for my basis of understanding the disease. Started patients on spironolactone with good results!
Hi Dr Sehault. This is great but with all due respect, does not address the victims of blood clots are mostly in African Americans including the young healthy and rich, not just the poor and old. This theory does not explain high reversible observation when oxygen is enriched with no increase in pulmonary pressure. Sickle cell trait covers both these observations and is statistically common in African Americans, it is silent until oxygen diffusion is low and then results in very sudden clotting especially the region near the lungs and very sudden.
I appreciate the excellent information you provide on what could be causing the problem, but how about discussing what we can do to overcome it, or prevent it from happening in the first place?
Be patient ! He’s getting there.
The mitochondria is the powerhouse of the cell
You are amazing! 👏
I’d rather pycnogenol, once and done. https://www.ncbi.nlm.nih.gov/pubmed/25391252
Int Angiol. 2015 Feb;34(1):43-52. Epub 2014 Nov 13.
Effects of Pycnogenol® on endothelial dysfunction in borderline hypertensive, hyperlipidemic, and hyperglycemic individuals: the borderline study.
Hu S1, Belcaro G, Cornelli U, Luzzi R, Cesarone M, Dugall M, Feragalli B, Errichi B, Ippolito E, Grossi M, Hosoi M, Gizzi G, Trignani M.
Author information
Abstract
AIM: This registry study aimed to evaluate the effects of supplementation with pycnogenol on altered endothelial function (EF) in borderline hypertensive, hyperlipidemic and hyperglycemic subjects without atherosclerotic changes in their main arteries and no coronary artery disease.
METHODS:
Flow mediated dilatation (FMD) and endothelium-independent (EID) dilatation were measured with brachial ultrasound after occlusion. Also, after occlusion, laser Doppler (LDF) flux and distal straingauge flow were measured. Oxidative stress (oxstress) was evaluated at 8 and 12 weeks. 93 subjects with borderline symptoms were enrolled into the study: 32 hypertensives, 31 hyperlipidemics, 30 hyperglycemics. All participants were instructed to follow the best available management to control their symptoms. In addition to best management, half of the subjects in each group used 150 mg/day Pycnogenol(®). 31 normal subjects were included as control.
RESULTS:
After 12 weeks metabolic values and blood pressure were back to normal in all subjects. Values were slightly better under Pycnogenol(®). FMD increased after 8 weeks from an average 5.3;3.4% to 8.2;2.2% with a further increase to 8.8;3.1% (P<0.05) at 12 weeks. No effects were found in controls and normal subjects. EID of normal subjects was consistently higher with 26%. LDF skin flux increased with Pycnogenol(®) at 8 weeks and 12 weeks. The final flux increase was not different from normal values. In controls flux after occlusion was not improved at 8 weeks; there was a significant but minor increase at 12 weeks. Flux increases were superior in all Pycnogenol(®) subjects. In Pycnogenol(®) subjects, limb flow after occlusion increased at 8 weeks with a further increase at 12 weeks. In controls inclusion flow after occlusion was comparable at 8 and 12 weeks. Oxidative stress was significantly decreased in Pycnogenol(®) subjects at 8 and 12 weeks. Minor differences were observed in controls.
CONCLUSION:
This open registry study indicates that Pycnogenol(®) improves EF in preclinical, borderline subjects in a macro-microcirculatory model. This observation may suggest an important preventive possibility for borderline hypertensive, hyperglycemic and hyperlipidemic subjects.
https://www.ncbi.nlm.nih.gov/m/pubmed/29713620/?i=1&from=pycnogenol%20crp
The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis.
Nikpayam O, et al. Clin Nutr Res. 2018.
Show full citation
Abstract
Pycnogenol is a standardized extract from the bark of the French maritime pine. The aim of the present systematic review and meta-analysis was to clarify the effect of Pycnogenol supplementation on C-reactive protein (CRP) concentration. To identify eligible studies in order to find clinical trials which examined the effect of Pycnogenol supplementation on the level of CRP in adult participants, PubMed, Scopus, and Google Scholar were systematically searched until December 2017. Mean of CRP was collected to estimate the effect size of the supplementation. Potential sources of heterogeneity were explored by subgroup analysis. Five trials including 324 participants were included in this meta-analysis.
Pooled effect size showed significant effect of Pycnogenol supplementation on CRP (-1.22 mg/dL, 95% confidence interval, -2.43, -0.003; I2 = 99%, pheterogeneity < 0.001). When the meta-analysis was subgrouped by dose of Pycnogenol, heterogeneity was attenuated in > 150 mg/d category (I2 = 0.0%, p = 0.42). There was significant difference between-subgroup heterogeneity (p < 0.001). Furthermore, no evidence of publication bias for CRP (p = 0.27, Begg's test and p = 0.62, Egger's test) was seen. Present systematic review and meta-analysis suggested Pycnogenol consumption can decrease the level of CRP and have anti-inflammatory effect. So, Pycnogenol as an anti-inflammatory agent might be a priority in interventions. Further studies with large-scale and better design are needed to confirm this result. PMID 29713620 [] PMCID PMC5921329 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446256/
Variations in Echogenicity in Carotid and Femoral Atherosclerotic Plaques with Pycnogenol + Centella Asiatica Supplementation
Gianni Belcaro, PhD and Umberto Cornelli, MD
Additional article information
Abstract
This registry study evaluated echogenicity of carotid–femoral plaques in asymptomatic subjects with increased oxidative stress and risk factors (mild hypertension, hypercholesterolemia). Supplementation with the combination Pycnogenol–CA (centella asiatica) on the echogenicity of plaques was assessed at 6 months (79 subjects). A standard management (SM) plan was used in all subjects (control of risk factors, lifestyle changes); 36 subjects used the supplements +SM; 43 SM only. The groups were comparable. High-resolution ultrasound evaluated echogenicity and plaque structure. Pycnogenol (150 mg/day) and CA (Centellicum, 450 mg/day) were used.
At 6 months, cholesterol was reduced (p < 0.05) in both groups (difference between groups not significant). At 6 months, plasma free radicals were decreased with the supplements (17.64%; p < 0.05; vs <2% in controls). The plaque stability index increased from 11.22;2.3 to 22.4;1.1 (p < 0.05) with the supplements; no significant changes were seen in controls. Plaque echogenicity (% of “whiter” component in images) increased with supplementation from 16.7;1.7% to 34.2;2% (p < 0.05); no variations were observed in controls. The maximum plaque height decreased (p < 0.05) with the supplements. No significant variations were observed in controls. Plaque length was decreased (p < 0.05) in the supplement group with no changes in controls. The number of plaques (carotid, femoral bifurcations) decreased with supplementation; no significant changes were observed in controls. No adverse events, tolerability problems, or variations in routine blood tests were recorded. The combination Pycnogenol–CA appears to improve echogenicity and stability of complex plaques in six months.
https://www.sciencedirect.com/science/article/abs/pii/S0006291X07015525 ?
Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress
I’m no Einstein, and not sure I followed much of the detail.
But they put me on *Proton Pump inhibitors* when I was 17.
I’m now 44. I do wonder about long term effect. I know it’s associated with dementia
He hasn’t gotten to treatment yet but likely boosting or augmenting the bodies glutathione will be key. It’s considered the body’s master antioxidant. Whey protein had been shown to help boost glutathione production (see link)
https://pubmed.ncbi.nlm.nih.gov/12537959/
Also NAC which he has already talked about and he states he is taking himself has been shown to boost glutathione.
Found this interesting too:
https://pubmed.ncbi.nlm.nih.gov/30160165/
Also this needs sung from the mtn tops: This is the first and only study I can find linking blood D levels to severity of Covid19:
https://vitamindwiki.com/Critical+COVID-19+was+19X+more+likely+if+low+vitamin+D+–+April+15,+2020
I just bought some NAC today 👍
Absolutely incredible presentation, you’ve done it again Dr. Seheult! Congrats! Many thanks from Belgium.
Thanks for your support and watching from Belgium!
saw a great video (on Ted?) where does your fat go. you breath it out as show here at 11:00
What happens when you rub your feet on a carpet ? Absorb static electricity electrons … Benefit or not ? Study by, Gene Bowdish
Again, THANK YOU FOR YOUR HONESTY, WELL PUT TOGETHER, NON FEAR DEMEANOR AND TONE, NON SENSATIONALIZED content meant to merely to incite fear/hatred/anger.
You have the most well presented content and portrayal of our current situation, as well as the etymology and process’s of Covid-19.
STAY SAFE, AGAIN, THANK YOU FOR YOUR HARD WORK AND EFFORTS AT THESE CRAZY TIMES, YOU DON”T GET PAID NOR PRAISED ENOUGH.
Greetings from Rome, Italy!
Thank you so much for all your
teaching so we can understand better.
If this is correct, does it mean that the vaccine could actually cause the same problem as the virus itself? If the vaccine contains the S-proteins to provoke an immune response these would bind to the ACE-2 receptor as well, no?
Can you talk about any treatments for this situation?
Do you guys over at Med Cram think that maybe you could make a summary of the things that have been covered in the previous episodes of this Covid-19 pandemic and touch up on the different ways of preventing it and recovering from it
Thank you, will you be answering Q/A
Please join us for our webcast tomorrow (Thursday, April 30: https://www.medcram.com/pages/covid-19-webinar ). Won’t be able to summarize 63 videos in 90 minutes but will review some key findings 👍🏻
Who is down voting these vids, Dr. Fauci’s crew?
Reduced = reduced positive charge. Oxidized means made more positive.
Excellent refresher and hypothesis. Look at these possibilities? SAR-Cov-2 also attacks Furin, GRP78, and CD-147 here—> https://www.youtube.com/watch?v=TAyWISZaykU&fbclid=IwAR0hMpD3djCXjKg26rRWmwBhNZaVqtzGpbkje2Q10bU4Tr3YMan8Z0ziMdM
How fast does this happen since the beginning of infection?
Dr. Cameron Kyle-Sidell talks about some of the things you are mentioning in the video I will link below! I think if doctors had a way to collab with each other across the country during a time like this we would all benefit! I think we are suppose to be able to rely upon the W.H.O. and the C.D.C. to do exactly that, but they have become top heavy and cumbersome with their own political pandering. What we need is doctors on the ground to do what they do best, science the sh!t out of this!
My prayers are with all of you on the front lines! and please keep the videos coming!
https://www.youtube.com/watch?v=Elgct0nOcKY
So, to get GSH Reductase, we need to take Vitamin C and D as we talked about?
https://en.wikipedia.org/wiki/Glutathione “Bioavailability and supplementation” headline
And Zinc and Cu for SOD. That is ofc to prevent us from getting damaged, but the Zinc and vitamin D also seems to help our immunesystem at same time.
So patients are presenting with elevated D-Dimer results indicating a clotting process is happening. Why are anti coagulants not being looked as a early treatment since the elevated D-Dimer is a indicator that the patient is going to have a more severe case of coved-19
Good point. He did mention in his last video #62 that a 72 year old healthy man came in with normal D-Dimer values but as he worsened, they increased. He was put on Heparin I believe… He didn’t mention it helped to stabilize him.
And the question remains.why some people are dying from this covid and some people don’t understand nothing…🤔🤔
Differences in diet is the major reason I guess and when you know the reason for the symptoms, it should be easy to prevent serious outcomes of Covid-19 with the right supplements like high dose Vitamine C to reduce oxidative stress.
HydroxyL radical.
I would be interested to hear thoughts on anti-androgens like spironolactone given that in rats there appears to be a androgen-angiotensin II receptor link, such that androgens seem to be inversely related with AT2R expression in the vasculature (“Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta” 2016). This is perhaps why men are worse off than women (i.e., their AT2R is being reduced by two mechanisms – the virus and androgens). ALSO – Makes me wonder if rhACE2 could be beneficial therapeutic. https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1823-x
Exceptionally great explanation. Clear. Concise. Wish I went to med school.
Does this mean that for people who ate poorly for many years, clogging their arteries, their bodies produced extra ACE2 receptors in their endothelial cells as a kind of coping mechanism? I thought I read somewhere that smoking causes the lungs to produce extra ACE2 receptors as well. This might partly explain why this disease is so hard on the elderly and so mild on the young.
So, people taking ACE inhibitors have more availabe ACE2 receptors, which leads in increasing the chances to get infected, but when they are infected, same ACE inhibitors decrease the creation of ANG II, will help to reduce the oxidation process making it beneficial?, does this make sense Dr. Seheult?
wow..suddenly alot of my med school biochem makes sense. An awesome presentation.
🙌🏼🙌🏼🙌🏼🙌🏼🙌🏼 your work is appreciated greatly
Since , in truth, we are all ONE in spirit I am offering free hypnosis to heal. I am using my 20 year of experience in hypnosis and energy techniques to reach out and help others.
Please join me for spiritual hypnosis healing at my site. I have prepared an article to inform you all about hypnosis, and three spiritual hypnosis recordings to relax and heal, to activate your immunity against COVID-19 and to boost your immunity. Please accept my gift of healing! http://nmtcanada.com/free-spiritual-creator-centered-hypnosis-for-strength-efficiency-and-functioning-of-your-immune-system/
Ouch- my brain hurts. But I think I get it.
3:20 Back to medical school…oh yea! Perfect timing for this lecture, Doc.
So how do you get tested for stuff like this not to happen? Does that show in your blood test ?
Excellent Information Dr Seheult & MedCram team!
What would be the effects of Fasting or intermittent Fasting on the mitochondria. Would it be beneficial against Oxidative Stress ?
Keto and IF rock! You bet! No vegetable oils! Only animal fats 😀
You are so smart!!!
This was the most elegant explanation of why prevention of disease through choices like nutrition are so important. This was the best medcram to date! <3
@Don Castella I didn’t get Keto out of this. However a very healthy lifestyle is really important – Keto is one way to do it, but not the only way. If you listen to the people in the century plus club, not one of them is keto ! If you’re fat and diabetic keto might be the choice for you. If you are thin, active, and healthy it’s good to eat God’s fruits .My 96 year old great uncle still drives, has sex , and sharp as anything – when I asked him about keto he said ” you people are nutts ?” Of course he loves a big slab of prime rib too, but loves fruits. So keto depends on who you are. I’m 51 and people think I’m 30 and I’m not kidding. I wouldn’t do keto , I think itd make me fat and have wrinkled skin – keto folks have terrible skin – u evef look at Dr. Berg closely ? Good luck !
Yes! In a word, KETO
That was very well done & explained Doc! Now I have to go & look for my old copy of Morrison & Boyd’s Biochem book to review some of what you discussed in this video. Looking at this from a cellular respiration point of view, it really makes a lot of sense. Thanks for your videos…….Stay safe…..👍👍
wow! as usual, so clear. Thank you so much….this all makes so much more sense…every day it gets clearer and clearer what is going on….
Eat Boccalli, capiscan and Apple cider vinger , to put anti oxidant and alkali metals into your cells. Plus avoid smoking, sugar and oil, it crops down the glycocalyx that covers and protects these cells.
3 cheers to you… best instructor award🏆🏆🏆
Theres no essential carb…
Absolutely love the video! You continue to mention the co-morbidities , Obesity, hypertension and diabetes. They are all the product of the same underlying disease, insulin resistance. Same as the oxidation of LDL in the presence of hyperinsulinemia. Correct? Yes or no?
And those are mainly caused by a bad diet
How does adding an electron go the superoxy radical produce H2O2?? You need protons for that. Where are the protons coming from?
Single protons ARE hydrogen and won’t just break loose from some nucleus .. And hydrogen can be found EVERYWHERE.
As H2 in the air or H is part of some more complex molecule.
This Looks like a Electron storage problem, if you have a build up of Free Electrons in the body, Not attached to anything this would provide a very large reservoir of electrons to be used to get rid ROS, these electrons being electrical can pass through all parts of the body, this sounds like Covit19 takes advantage of a Body that is low on electrons, a Body that is NOT up taking a Large dosage of electrons. I have said it before and oi will say it again. GROUNDING /EARTHING to uptake a Large amount of Electrons to get rid of all Inflammation at a a Very High rate, also Grounding Oxygenates red Blood cells to their Maximum capacity. the attachment is a human study that discusses Grounding on the Immune system. I sleep Grounded, and Ground my body 20 hours a day every day, to keep my Electron storage Full. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378297/
Question: So, is the intake of Oxygen via alveoli normal during this process just illustrated?
I hope all the prospective med students are using these videos to keep on their toes during this lock down 😉
Fantastic explanations – I knew nothing about your topics but can easily follow the information 🙂
Delightfully easy to follow for me, whose biochemistry background and understanding are so thin. Thank you so much for your patient, thorough explanations of these processes and their implications in disease emergence.
God bless you and your staff for your brains….retaining all this knowledge, and simplifying it down for us .whew! 😬
We are complex and wonderfully made . Wow
Any comment on Fauci announcement about remdesivir. Trial stopped and adopted as standard of treatment.
Sounds suspicious. Need more time
to determine the efficacy of remdesivir
unless it was already known.
That is absolutely brilliant!
Yey! Finally! In Italy we know that since a month ago, we did many autopsies so it was easy to see. The cure for coronavirus is a lot of Heparin plus antiaggregants. You are welcome, please next time try learn other languages and read what is going on in Europe.
Don’t be an acehole!
From having a hunch to strong indication to FACT is a couple of steps and takes time.
Autopsies indicated this, however most of the dead were men of higher age and most arterial issue might have been pre-existing.
It’s the FEW young people with strokes that got doctors puzzled.
Also basically ALL medical publication IS in ENGLISH, No matter where it comes from.
If you want to bitch about someone, blame the CCP.
Either they didn’t pass on information from autopsies or they were so busy covering up they burned all the bodies before anyone could cut them open.
2D Notte I have several of these most every day: https://naturalbloodthinners.org/herbal-blood-thinners-list/
Wow chill
Impressive lecture…the 1st half explaining the oxidative cycle is worth the “price of admission”, lessons with knowledge that can be useful for a lifetime.
Wow. This lecture reminds me my biochemistry lessons on the nursing college. I’d been sruggling to pass the exam and I was completelly lost. If I’d had these lessons in those times… I’d be much more into the biochemistry. It is very adventurous journey to go through your lectures, doctor. Thank you for your teaching.❤️🙏🏼👍🏻 Can’t wait to see another lecture.
Keep ’em coming, doc!
Again, someone answer this question: drinking low solution of salt water will help in preventing or fighting covid-19?
Michael Jin no
I feel like I’m witnessing the beginnings of an understanding of something very important to mankind.
Lol.. your witnessing doctors being taken to school by the magnetic universe.
Baking soda makes you a better battery
you said it.
for real
virus has dogged mankind for long time.
this is fundimental research that may go a long way at understanding extremely complex biology and virus interaction that maybe a new field of medicine/science take place that end the pandemic problem in humans and animals once and for all.
This whole thing has been beyond fascinating.
https://www.ncbi.nlm.nih.gov/pubmed/12419687
https://www.ncbi.nlm.nih.gov/pubmed/17440995
Might be a good idea to consume some green tea.
You know, people kept joking about how highschool was useless since all it taught us was “the mitochondria is the powerhouse of the cell” but I feel like learning that was probably more useful for more people right now than learning how to “balance a checkbook”.
Thank you for your hard work! It looks like children are being affected by it already in Europe and it seems that they are not connecting the dots. Here Dr. John Campbell last video talking about it.https://www.youtube.com/watch?v=wvSqHONt4tA
Again, thank you so much for your lectures!!
#OxidativeStress
My country Brazil,the situation is really sad here
Is this, in addition to the proposed zink effect in the cells, why quercetin can help? Being an antidoxiant?
Thank you so much,,
Awesome, this lecture took me back to metabolism class as a Food and Nutrition major in college. I love the names of superoxide dismutase, glutathione peroxidase, especially, their important effects on oxidation of cells /free radicals. Catalase included of course. Thank you!
I hope in next episodes synergy with microwave radiation will be taken in to account keeping in mind studies like these: https://link.springer.com/article/10.1186/1477-7827-7-114 https://www.tandfonline.com/doi/full/10.3109/15368378.2015.1043557
I’ve also heard that giving intravenous vitamin C can possibly help. Might this be because it is a powerful antioxidant?
Check out today’s interview with Judy Mikovits.
Do you have a link? Thanks!
I think you are on to something. 🙂
I’m not college educated but you make it easy for me to follow along….much apprediated!
Awesome video! Thanks! We actually put out two videos on Ivermectin for COVID-19. One is an in vitro study with 99.99% decreased viral loads (dosing may be an issue though!) and the second is a retrospective observation study in actual COVID patients. We were quite surprised by the results. Would love to hear your thoughts on the two studies and their utility. Both are linked below!
Clinical Trial on Ivermectin: https://www.youtube.com/watch?v=8Z1Oc4_99sk&t=33s
In vitro study on Ivermectin: https://www.youtube.com/watch?v=npcuIWw6y1Q&t=4s
Cheers,
WBDR
You mentioned this as a possible explanation as to why people with diabetes, heart disease, and obesity might more sucseptible to this virus, but another at risk group is those with asthma. How does SOD and NADPH come in to play in those with asthma? Are these functions already reduced when compared to a healthy population? It would be interesting if this oxidative stress theory could provide an explanation for them as well.
Wow. Great content for free. Thanks Doc!
What was the first bit again?
🙂
Is this Doc currently working with Covid 19 patients in between making these videos??
I’ve wasted my life
Ikr??!!
Yes, he is a Super Doc.
It’s not too late to shape up.
Yes, he cares for Covid patiens.
This is the only channel i mark videos with a ‘like’ before seeing the video. Thank you Dr. Seheult 🙏🏻
Brilliant! Dr. Seheult for President!!
*Dr. Seheult, can you do a vid on XMRV (Retro Virus)*
To me, it’s looking like a need for more Niacin in the body, along with VD3, B2, C. ??
Please explain why ACE Inhibitor antihypertensive meds that reduce the activity of angiotensin converting enzymes, (specifically Ang 1,7) are being PROMOTED to fight against Covid-19.
This appears to be faulty, and is promoted more due to fear of patients stopping their meds, similar to the original claims that masks were ineffective for the populace due to fear of mask shortages for healthcare workers.
In other words, there continues an underlying agenda more concerned with controlling behavior than providing sound scientific theory.
Well theres been reports that it protects. they studied patients. https://www.news-medical.net/amp/news/20200429/ACE-inhibitors-appear-to-be-safe-and-beneficial-for-COVID-19-say-researchers.aspx
I am grateful ……
This is the best channel on Youtube right now. Really interesting stuff.
Dr. Seheult, you’re an absolute boss sir. Your lectures, medical explanations, and analysis are second to none. You are able to turn highly complex topics into simple enough concepts so that non-professionals such as myself can learn and make sense out of such complexity. You’re an outstanding educator, researcher and I can see the passion you posses for your vocation. Never stop making these presentations, you’re doing amazing work. Thank you!
I like his presentations with wheels. I know …stupid (me) but it kept me focused.
Joel Chaparro, agree, all was well…. until this one……. lol, by the 18 minute mark, I was all glassy eyed
Best COVID-19 information on the internet right here.
Incredible information! Thank you!!
That was amazing! I’m a bit thick and I totally got it! Good job.
Is there anyway you can draw any conclusion on the role of ACE inhibitors and ARBs on whether it will have a positive effect or negative effect on this virus.
piruz87 right….you would think given the solid understanding of the physiology as presented here that a consensus could be reached on the use of these either way.
How do you know so much of microbiology and chemistry as a pnuomologist? This stuff is more for pathologists and biologists..im very impressed
Good physicians keep up life-long learning long past medical school in all areas of medicine, but especially in areas relevant to their own specialties. These days, any good internist should know about ROS and inflammation, since they’re at the root of most diseases seen in internal medicine.
Thank you Doc, from Greece
Thanks for tuning in from Greece!
Another fantastic presentation. Why couldn’t you teach me in college? I learn so much and so easily from you. Please keep up the great work.
this is scary and highly informative at the same time, and somehow i like that…
Was wondering if you could do deep dive on what researchers, epidemiologists and pandemic experts etc have to say on the effects of mitigation vs containment. So many news articles are trying to convince the public its safe to go back out and just let our immune systems take care of it. That recent video by Dr. Erickson (https://www.kqed.org/news/11814749/bakersfield-doctors-dubious-covid-19-test-conclusions-spread-like-wildfire) has have over 1,000,000 views and he isn’t even practicing I don’t think.
So antioxidants are important if this is true??
Stunning and amazing presentation sir ………
Thank You sir
All Glory to the creator!! The human body is so complex it has to be disgned by a all knowing designer
The same could have been said of the US Tax Code.
If quercetin functions to block/occupy the ACEII receptor so the coronavirus can’t enter the cell, wouldn’t that cause the same adverse effects as if coronavirus had occupied these receptors? So it would be harmful to take quercetin?
Thanks for your efforts and dedication, not to mention your front-line work! Could large dose Victamin C assist in reducing the oxidative stress? https://www.intechopen.com/books/vitamin-c/vitamin-c-an-antioxidant-agent
How does this explain death in young healthy people where one would not expect these comorbid deficiencies or conditions?
eNOS is only fully coupled when it binds its substrate arginine and its cofactor tetrahydrobiopterin (BH4) [53]. The oxidation product of BH4, dihydrobiopterin (BH2), competes with BH4 for binding to eNOS; an elevation of the ratio of BH2 to BH4 therefore is associated with eNOS uncoupling [96-98] Analogously, ADMA competes with arginine for binding to eNOS, and a relatively high ratio of ADMA to arginine likewise promotes uncoupling of eNOS [99]. Endothelial oxidative stress, whether originating from NADPH oxidase activity or other sources, tends to boost levels of both BH2 and ADMA [53]. BH2 increases under oxidative stress owing to direct oxidation of BH4 by oxidants such as peroxynitrite; in addition, oxidative stress may somehow down-regulate endothelial expression of dihydrofolate reductase, an enzyme capable of reconverting BH2 to BH4 [97,98,100]. Oxidative stress also tends to boost endothelial ADMA levels by inhibiting the enzyme responsible for its catabolism, dimethylarginine dimethylaminohydrolase (DDAH) [101-103]. And eNOS can be uncoupled by glutathionylation, which is more likely when oxidants boost cellular levels of diglutathione [106-106] Hence, uncoupling of eNOS may be a consequence of NADPH oxidase activation in OSA – leading to a further increase in oxidant production that would tend to maintain the uncoupling of eNOS in a vicious cycle.
Fortunately, there are practical nutraceutical strategies that can promote the recoupling of eNOS. The adverse impacts of elevated ADMA and of increased arginase activity can be offset by increasing endothelial levels of arginine. This is best achieved by supplementing with the amino acid citrulline, rather than arginine per se [107-109]. The utility of supplemental arginine is compromised by inducible arginase activities in the gastrointestinal tract and liver, such that only a small proportion of supplemental arginine reaches peripheral tissues intact. Citrulline, however, is well absorbed and well distributed to the body’s tissues; within cells, it is efficiently converted to arginine. Hence, supplemental citrulline functions as an efficient delivery form for intracellular arginine. The utility of supplemental citrulline – usually administered in a range of 3-6 g daily, in divided doses – has been documented in clinical circumstances associated with eNOS uncoupling [107,110-114].
Great video! Coming from a biochemist, some of the chemistry in this video was represented not quite as accurately as I would have liked. Nonetheless, a fantastic collection of information!
It has to be understandable to normal people, so the informations are reduced to basics. Biochemists are in fact walking talking alien super brains.
Would a low carb diet(ketogenic eventually) lower the oxidative stress overall?
Could we supplement SOD and Zn to make the antioxidative system be more efficient? What about Vit C?
As it’s known as a low inflammation diet; yes.
Greatest Covid video !!!
If Khan was a medical doctor, this is it! Awesome!
Fascinating
Has anyone noticed that a lot of study articles and research papers that the doctor went through in these videos are authored by a bunch of Chinese names? They must have come from some institutes in China. It’s a shame that the political leaders in both countries (US and China) are bud-heading during this global crisis where they could have done the world a super great service if the scientists from both nations are allowed to work closely together to find the cure for humankind.
@E. Lee Doctors and researchers from everywhere are communicating with their opposite numbers in China every day. Chinese medical research papers are being translated and published in the West all the time. The web is a wonderful thing.
@Tom Terific What do you bet…when the pandemic starts to fade from top-of-the-news-hour sound bites, the far-right will begin digging up “authentic” documents claiming that Mao and Xi both had Jewish mothers. Hear me now, quote me later.
@Ken Hudson Um, it’s the Chinese gov. that has forbidden any doctors/researchers from anywhere going to China. No foreigners at all allowed in.
@Ken Hudson Umm, actually, they HAVEN’T abandoned their anti-semitism. They’ve just supplemented it with another target.
The xenophobia in the USA in recent weeks has been horrendous. The same ones who used to post anti-Semitic memes all over the web suddenly decided that China was the new enemy-du-jour. And completely abandoned the anti-Semitism in favor of anti-Chinese tropes. Obviously in order to deflect attention from the failures of Western political leaders to learn from the Chinese experience. Might have been very different if epidemiologists, virologists, and clinicians had taken center stage right from the beginning.
To be honest, I fell asleep. He has a very calming voice.
furosimide
I think I missed something at 14:45 How does adding an electron to an oxygen molecule suddenly spawn a hydrogen atom? Where does the hydrogen come from?
Probably because some H will want to grab a hold on the O’s surplus E, while the O is holding tightly onto the E.
While O is super electronegative, H is pretty electronegative too (that’s why H2O forms so easily and is hard to divide, with both atoms holding tight on the shared electrons) and it is EVERYWHERE.
Maybe breaking itself lose from some molecule, leaving some change or even damage elsewhere.
Because a free election attracts a proton. 1 proton is a hydrogen atom
fauci just came out on the news and said remvesitir is showing promise
Huh, I thought the other complications were because of the damage to the lungs. So this thing can even infect arteries!?
And intestine and brain too.
Knowing this is frightening. However, with knowledge comes power and your research is nothing short of incredible! I can’t thank you enough for keeping up your continued work on fighting this disease!! Your videos are amazing, I have never studied medicine and still you manage to explain everything in a way that normal people such as myself can understand this. Stay strong Dr.
Are varicose veins a possible warning sign of increased risk for a severe type L covid-19?
I can’t believe I followed all that. I thought I had forgotten HS chemistry and anatomy. But I’m still trying to figure out how ACE Inhibitors affect this.
Check out his update #37 for some insight into your question.
Or ARBs… do they help or not?
Been looking forward to this one
Thank you
👍🏻
There are antibidies against ace2, and don’t make lungs disease, there might be another problem. Angioedema makes edema, vessels grow, haemorragies in lungs, and happens quickly, doesn’t relieves with steroids. Does anyone tried to use danazol or trexenamic acid? Thanks
To what degree would a diet high in antioxidants help block the ROS produced in this situation? In other words can antioxidants help with the fallout?
This peer review article came out in the New England Journal of Medicine back in February by the Keebler Elf Dr Fauci
—-
Covid-19 — Navigating the Uncharted
List of authors.
Anthony S. Fauci, M.D., H. Clifford Lane, M.D., and Robert R. Redfield, M.D
—-
3rd paragraph in
—-
On the basis of a case definition requiring a diagnosis of pneumonia, the currently reported case fatality rate is approximately 2%.4 In another article in the Journal, Guan et al.5 report mortality of 1.4% among 1099 patients with laboratory-confirmed Covid-19; these patients had a wide spectrum of disease severity. If one assumes that the number of asymptomatic or minimally symptomatic cases is several times as high as the number of reported cases, the case fatality rate may be considerably less than 1%. This suggests that the overall clinical consequences of *Covid-19 may ultimately be more akin to those of a severe seasonal influenza (which has a case fatality rate of approximately 0.1%)*
—-
We’ve all been hoodwinked and the media keeps ignoring stuff like this.
remember this is for all other doctors to read as a peer review article – in other words the sets the Baseline
@SCDHL Don’t forget this is a novel virus. At that time, it’s all that was known. Clearly we are learning as we go. As for the media, skip it entirely if this is what interests you and come directly to sites such as this one.
Australia will be going into Winter in a couple months, I want to watch it for what happens during the winter.
So is it a good idea to take zinc, copper, and manganese supplements at the onset of symptoms? Or is that mechanism already broken so it’s pointless?
@b. ho and NAC it looks like.
In an other video Dr. Seheult states he takes Quercetin + zinc + vit c + vit d + (help me here someone) as a prophylaxis to prevent infection.
What’s for sure, and he said this before, is that you shouldn’t have a deficit in these elements.
The body will figure out how to use them.
Natural sources of these elements will probably be of higher value than artificial supplements because it’s those sources man’s body has learned to use over a very long time.
Seems like SOD can still work against ROS but you still need an ionophore to get Zn into the cells – or maybe Cu and Mg are transported to the cells more easily and that’s a better solution?
I think the clear thing here is that any of these remedies work best when introduced early in the cycle because ACE2 being inhibited only accelerates and becomes a domino effect in these system processes.
Bravo! This means that anti-oxidants are a key factor, especially in the early stages of the disease?
@larissa mclean glutathione?
You can buy glucathione drops. I got sick with covid wirh mild symptoms. My super clever gp gave me glucathione to take everyday. I recovered within two weeks, as it was mild anyway. Glucathione tastes and smells horrible but helps a lot.
@tranhoang vitamin D helps prevent this ace 2 reception
No, the goal is still to block the entry and further replication of the virus in the cells which is mediated through the binding of sars-cov-2 to ACE2…
@Bernardo Cantu yeah
So, possible step toward validation of the whole intravenous vitamin C routine, huh?
@Hello Again tumeric reduces oxidation?
Careful…YouTube might ban you for sharing this life saving info. Not happy with YT atm.
Also makes the Tumeric seem like it wasn’t just wives tales after all
Thank you for explaining this , it was very helpful . Zinc In particular interested me of the SOD , as has been mentioned in use with the malaria drug in early treatment of Covid-19 .
Superoxide is not very reactive- it is a reducing agent (despite its name). Superoxide can give rise to other species that are reactive. Hypochlorous acid is a species that kills bacteria and other microbes.
Man, you are awesome! I’ve been following this channel awhile now and am impressed and inspired everyday. Your graphic representations are beyond helpful for me! As a nurse, and human, I want to say thank you for all your efforts, YouTube and otherwise, in combating this virus!
🙏🙏🙏🙏🙏🙏🙏
I don’t comment much on the ‘net’ but I’ve been following these Medcram Vids and this one, which I managed to follow even tho I am not currently in the medical industry, is just unbelievably good. Incredible clarity and thanks for **another** great video.
The effect of quercetin supplementation on selected markers of inflammation and oxidative stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685779/
Again, I much appreciate the clear lecture.
One item of info I am challenging though is the suggestion to ingest high carb with the fats and proteins:
** Any amount above 50 grams of carbs is excess and toxic to the body, especially if it is in the form of fructose and sucrose.
It is a good thing that this pandemic did not occur before I went on a ketogenic diet at the beginning of 2019 last year, and proceeded to lose over 45 lbs and six sizes – from a size 12 to a size 6. In hindsight – although I did not go to a doctor and get diagnosis – I did see how I had the symptoms of pre-diabetes or even possibly diabetes. I definitely was suffering from metabolic syndrome and something sparked me to try the diet out, and am extremely glad I did, or else I would have been in the high risk percentile of greater susceptibility to Covid19. No doubt about it, the people who are experiencing the arterial damage from what is described in this video need to take in high quality fats for a cleaner metabolic burn which ketosis provides to help heal ALL organs and cellular oxidative stress which very likely is the precursor vulnerability condition to thus even more serious result from the virus getting past a weakened immune system, again which goes back to the high carb, sugary diet in the first place over a many years of abusing the body’s pancreatic and liver functions.
Right now, my heart and arteries are great.
Energy level is stable and much stronger, and I’m able to comfortably work in a 24hr period, two 8 hr shifts at two different warehouses, where I’m having to do lots of walking exercise/carton lifting. And I am engaging in artwork as well on my off hours. I cannot say enough about the keto diet and low carb way of life. It is just absolutely awesome.
@NavyVet I understand, acknowledge and appreciate the processes clearly explained by Dr Seheult. You are apparently not grasping my point. Ketones are a cleaner burn in the cells, and much more beneficial to recovery chances especially when there is metabolic deficiencies to begin with and which contributed to the patient contracting a severe case of the Covid19 disease.
Extensive clinical studies have been done, and experiential proof of low carb/high fats/moderate protein is happening all over the world. Keto gets to the root of the problems. You can start here in delving into the growing educational data and practice –
https://youtu.be/4WPF3RMPI9k
As a matter of fact, intermittent fasting which leads to beneficial autophagy’ along with the medical treatments that have been successful so far, also strengthens the immune response, and would help virus patients to recover effectively and completely.
NavyVet yes I also agree with you…carbs are a fuel…too…not the best for me…I have found out…the hard way…have autoimmune
I do not believe that there was any suggestion to anyone to injest high carb with fats and proteins. Rather, it was a description of how energy is created in the mitochonrial DNA. The process involves the conversion of any of the three (Fat, Carbs or Protein).
Love your comment ! Carnivore for almost 2 yrs low carb since late 90s ! Totally agree with you! I invite people on this channel to watch Dr Paul Saladinos channel as well…
I got here to see 666 likes… Guess I’ll take care of that lol
I think median age of countries matters way more than people give credit to. This would explain better outcomes in many poorer but younger countries.
Is oxidative stress what we non-medical people call “inflammation?” Thank you so much for this information, doctor.
@Tom Terific Thanks so much, Tom.
@Tom Terific Thank you for this explanation.
Sarah TJ inflammation is a single type of oxidative stress due to the immune response activating neutrophil and macrophage cells which kill pathogens by producing ROS.
Tom Terific ✔️
No. Oxidative stress is damage which is caused to cells by these “reactive oxygen species” molecules. https://en.wikipedia.org/wiki/Oxidative_stress
Inflammation is a protective reaction of the body and the immune system. https://en.wikipedia.org/wiki/Inflammation
higher temps will do nothing since brazil is going crazy
Please excuse the question in advance does vitamin c in high doses orally or intravenously have a antioxidant effect that could hedge or put a blow in the oxidative stress process?
Don’t take high doses of vitamin C, it has side effects
Better intravenously when sick
Yes try 30 mg of methylene blue too
https://www.ahajournals.org/doi/10.1161/circ.99.9.1272/a
but why do you think the effect is so fast? oxidative stress needs a lot of time to make you sick.
5 g
This is a great explanation. A Med chemist could follow along no problem!
Just a listener, but why when you are talking about gaining an electron that the “H” (hydrogen atom) nomenclature is used?
Can any chem grad here explain o² to h2o properly with H ions or molecules. Basically balance the equation
So what is the verdict on people taking ACE inhibitors? Would this exacerbate the process?
It seems that I’m present for every vlogg.
i have been watching every single med cram since like update 16 . thanks to this organization I am now ready to take biology and …..and I’m excited about it!!! thank you!!
I heard when the brazilian doctor Elnara Negri, back in early march first said that. She had a insight when she saw an old lady in the hospital with a dark finger on her foot. That was brilliant! Now NY is copying her, along with some countries in Europe. She was spot on! I hope this becomes the strongest protocol to covid19. Hoping for the best!
@shari duke a finger that is dark
What is “dark finger on her foot”?
I think this must be my favorite channel on YouTube now 😂 Im crazy with rainbows/colours and science freak so this is the best 😍 Unfortunately I dont have much hope for working in the science world 😭💔
Fortunately nowadays it’s way easier and cheaper to access scientific books and information in general.
Even while working in a different field, if you’re PASSIONATE about it and can spare some time, you might teach yourself some (more) science and maybe you’ll encounter an opportunity to work in science after all.
.. Or at least have gained some knowledge you might apply in your everyday life.
1918 same
Holy Crap!!! I have been watching your video series since day one….This makes sense and hope it can lead to an effective treatment. Thank you for you invite and tremendous research efforts.
So, now we need to know how to increase S.O.D.
A G cruciferous vegetables. You can get sod in a supplement but not sure that works…..
Gosh I need CME for all this too!!
Brilliant lecture
Thx!
This is pure gold
Melatonin Impairs NADPH Oxidase Assembly and Decreases Superoxide Anion Production in Microglia Exposed to amyloid-beta1-42
Vitamin D Receptor Activation Influences NADPH Oxidase (NOX2) Activity
N-acetylcysteine inhibits NADPH oxidase activation and attenuates lipid peroxidation in the heart, lung, liver and kidney in streptozotocin-induced diabetic rats
I recommend Cells at Work, on Netflix, for another extended examination of these processes and the species involved. https://youtu.be/UfXoVZu8GLs
This is absolutely fantastic information 👍
All The Studies I have Been Reading says THE NUMBERS OF DEATH IN US CAN NOT BE TRUSTED! LOOK AT THE STATES GOING BANKRUPT They All Have The Highest Cases and Highest Deaths. The More Of Each They Have The More MONEY THEY GET!!! THANK YOU FOR THE TRUTH!!!
1. Wear a mask when going outdoors, be it work or just going to enjoy life 2. Excercise and workout, important in staying healthy if u tired of looking like a fat arse.
@Don Castella it’s good advice to use them in crowded environments. Even outside isnt it?
Masks aren’t needed outdoors and will hamper your workout and lower your SPO2
Yes and avoid vegetable oils go low carb …increase animal fats
Wow, back to uni, loved these then, had a poster of Krebbs cycle and a huge mitocondria with jumping electrons on my wall – and love these today 🙂 life is so miraculously beautiful, it has to be protected.
Meet you all on Thursday.
Haha, finally getting to use my Chem and Bio knowledge…great review and love the pathophysiology of Covid-19.
I had a similar poster. In fact, I might still have it in my closet. If I find it, I might put it back up on one of my walls.
I hope you don’t get banned by Susan Wojcicki for this…
I would like an explanation about monocytes and lymphocytes and why the monocyte looks just like the coronavirus under a microscope
You need to talk about the CA antibody testing results. 33,865 cases out of 280,900 total tested. With sample sizes like that, self-selection bias becomes less of an issue. Even if the ratio is a quarter of what the banned doctor’s said, it would still mean the death rate is at most 0.1%.
Do you have a link? I haven’t seen that study.
I’m downloading this video, just in case.
@MedCram – Medical Lectures Explained CLEARLY I have no intention of reposting it, I also wanna say thank you for continuing to produce these videos. Can you possibly touch on chloroquine and hydrxoychloroquine possibly doing more harm than good because they both seem to cause oxidative stress?
This probably goes without saying, but we ask that you don’t publicly repost our videos without our permission (thank you!)
just plug in “youtube download” to a search engine and there’ll be some sites that let you plug in a link to a video and will give you a download link for it
Genuine question. how do you download YouTube ?
It’s insane that we have to do this, isn’t it? What kind of weird, Orwellian dystopia do we live in?
I hope you will post the webinar so that I can listen to it later. I would love to hear it because I have followed all of your posts in order to figure out how to deal with my own personal health situation. (Bad as it gets, high risk, elderly, multi-generational household). I don’t feel ok about taking up a space which might go better to a medical professional. Because of your posts, we are doing everything we can to reduce risk, my favorite post what the ‘what I do when I get home to not bring the virus into my house’. It makes me feel better everything I bleach wipe my light switches. Zinc is daily….
Just one tiny error — it’s “hydroxyl radical” not “hydroxy”. Amazing lecture as always!!!!
Yeah mr perfect.
Rupall 20mg every 12 hours. Problem solved pandemic over.
@John Smith https://www.nature.com/articles/s41598-018-22285-x
@August West lol 👍 learning is good Rupall is a brand name for rupatadine a second generation antihistamine that also blocks platelet activating factor and TNF a1.
Cmac i Wikipedia’d Rupall and there was an interesting factoid related to RuPaul. I learned something new. Thank you
Cmac please explain
11:10
_cough cough_ fluorine _cough cough_
Is COVID-19 transmissible through blood products? If someone receives a blood product contaminated with COVID-19, will they develop COVID-19 and suffer the effects that you talk about here? If so, then our blood supply is probably contaminated since American Red Cross is not testing every blood product that they collect for COVID-19 and obviously there is no way just by looking at a person who might be asymptomatic of determining if they have COVID-19 without doing some type of test.
Molecular Hydrogen cures Oxidative Stress, HydroShot provides Molecular Hydrogen.
Thank you for your interest in our product and contacting us. We do believe that Hydro Shot may be effective but need to have patient testing.
We have been trying to work with different agencies and doctors but without success. We have even tried contacting doctors at nursing homes that have publicly confirmed they have folks with the coronavirus but they never responded.
All we can do is lead the horse to water but can’t make them drink, ha!
Thank you again for your interest.
Stay Healthy,
Kurt H. Ruppman, Sr.
CEO
214-794-7009
http://www.h2bev.com
Literally the cutting edge of medical sciences, right here on MedCram!
Pretty sure you meant figuratively
LITERALLY!!!!
Where else?
Absolutely well said! This dr is absolutely amazing! I’m so blown away that my mind is fatigued. I don’t have any type of medical background but I see the concept and ideas form thru his explanations. Incredible man!
very informative
Thank you!
Thanks again for taking the time to make another video to keep us inform.
Much learning, thank you very much.
Doc, you should give us the potential cure based on your studies, knowledge and research
Today.German reopened,but had contagious corona virus. SoYou have to ask CDC To create or develop [Wu Han corona virus amount detecting app or device ] ? This app or device can caveat people when there are many [Wu Han corona virus amount] around or near you and this app or device can make warning sound to tell you to be careful. Taiwan.
This is beyond amazing, thank you so much Dr.
Sweden will be proven right. They’ll have the same number (or maybe even fewer) of deaths per capita as the United States and Europe, they’ll actually peak sooner and achieve herd immunity, and they won’t destroy their economy. How? By staying open for business and treating their citizens like adults by allowing them to govern themselves. The rest of the world decided to follow Dr. Fauci over the cliff and adopt the Chinese authoritarian regime model. Great advice, Fauci. Thanks for destroying the greatest economy in American history.
Numbers if infections and deaths in 🇸🇪 are rising and approach is questioned.
Cheers from 🇩🇪/🇪🇺
..where we slowly/carefully start/ed reopening business AFTER thoroughly discussing and implementing rules once PPE got available again.
Med School nightmares deja vu!
https://youtu.be/NJYSsJN431I
Wow, this is so interesting! Thank you for explaining this clearly, it sure does start to tie a lot of loose ends together
fascinating!
So now the theory is shifting from the lungs to the blood vessels. I have seen other vlogs stating the same, saying it’s more of a blood disease. This virus is a sneaky little monster for sure.
Kind of a creepy thing to think about is that it’s acting on the same cells–endothelial cells–that Ebola virus goes after, except that here, instead of causing vessels to leak blood, it’s inducing clotting. Imagine if Ebola could be transmitted over the distances that this one is. In that way, SARS Cov-2 is much scarier than Ebola.
It’s both! And more! It’s neurological too. A wide variety of cells have ACE2 receptors.
This is such an awesome review. It’s like being back in undergrad again in my Biochem course at UCLA!
Amazing explicit: great
I wish I had a biology teacher like you in school. Thank you!
Question: for people who do catch the virus, is there any data as to what proportion who have breathing difficulties (shortness of breath) also develop a persistent cough? What about vice versa? ie. are these two symptoms strongly correlated? I have a friend who has developed a nasty shortness of breath; his GP told him to self-isolate for 7 days (plus the household he’s in for 14 days, which is his elderly parents) and she said that the fact he was still able to speak in sentences made her think that it wasn’t Covid (or a very mild case). Thoughts? My friend does have anxiety issues anyway, but I’ve known him for 25 years and he’s never mentioned breathing difficulties before (he’s in his mid 40s, does not smoke or drink, is fairly fit as he cycles a lot, and has a decent diet). His GP suggested he look on the NHS website (we’re in the UK btw) for some breathing techniques; have you heard anything about methods of breathing that can help?
@Pretty Young Thing PYT He can’t because he’s not classed as a key worker and atm the symptoms are not (yet) serious enough to warrant emergency aid. Drive-by testing places are only for “key workers”, as defined here:
https://www.gov.uk/guidance/coronavirus-covid-19-getting-tested
If either of his parents develop symptoms though then he would qualify to be tested (as would the parent), but emergency treatment at a hospital is dependent on having more serious symptoms.
He should go to the ER. You guys call it A & E over there.
I’ll keep saying it but Citrulline(NO precursor that works in a unique way and bypasses certain processes, REDOX), Alpha Ketogluterate(Krebs cycle, REDOX), and high dose Vitamin C(BH4, REDOX)
Geez, you figured this all out on your own? You should be getting a medal fore this sunshine. Now my question is, where do we go from here? Treatment’s? Meds? Prevention?
He retold some biology and read a couple of studies. He doesn’t do original research here, why would he get a nobel prize?
He needs a damn Noble Prize for this work!
@Kerry Smith Great advice, and reduction of sugar is key, too; fresh vegetables (green in particular) and low carb fruit such as avocado (bonus = healthy fats).
Check previous lessons.
Take Tamydon
My wife survived 30 days on a vent with covid, is there anything we can do to increase her survival rate from here? She is improving daily and can almost walk by herself and almost take care of herself.
I hope your wife improves soon. I would suggest getting off carbs, fasting. See Dr. Jason Fung. Take D, C, etc
My neighbors son in law spent 30 days on a vent and survived. His heart stopped at least 2 times and they brought him back. He is at the starting point of recovery too. Best wishes to you and your wife these are extremely trying times
Kenny Martin I will pray for her to get well as best she can.
And btw she has type 2 diabetes, nash, ibs and beginning ms..
Why do you always review the numbers when we know sufficient testing is not being done any place.. Just curious.
even if the numbers are wrong, those are the only numbers available. You do what you can with numbers. you have to start somewhere. The numbers that he mentioned in other videos are based on numbers of patients accepted to hospitals and UCIs those numbers are more important than the overall numbers of people infected.
Thank you MedCram.
Can I take Reduced Glutathione, NAC plus Vitamin C?
Always look forward to hearing your updates! Thanks for taking the time to do these even while being a full time Doctor. I’m an ICU nurse here in NC and I’ve been watching your videos for years.💜
God bless you! Stay healthy and strong!
loved it
Yawn…… N Acetyl cysteine
@Joe i posted underneath. Sorry.
@Billy The Kid studies show it cuts down the flu 75%. It Won’t stop you from getting a virus but it stops it in it’s tracks. No one can make money off of it though. Check out the research on it. It’s amazing.
@Joe https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/
@Joe N-acetyl cysteine (NAC), as a nutritional supplement
Joe I think it reduces oxidative stress. Probably not enough to make that much of a difference
Why hasn’t this information been on mainstream media 🤔?
Look at all the background he had to give–and even that was greatly simplified. Mainstream media reporters and the general public would be totally lost. The average American’s understanding of free radicals and oxidant stress comes from watching Pom Wonderful commercials. We just have to accept the fact that this channel is weeks ahead of the lay media.
In reference to update #65, would taking an angiotensin II blocker like losartan have a positive or negative impact in a patient with CoViD 19?
@Moe J. and how does ace 2 get damaged? Oxidation?
Doesn’t matter if ACE2 is damaged
How did these very few stroke cases just SUDDENLY appear? Covid-19 has been here since 2019 and nothing has been reported about strokes until now…
Autopsy.
Obviously this disease was ‘misunderstood’ with the focus on the lungs here in the West and the Chinese either didn’t have a clue themselves or didn’t inform about ALL findings.
Dr. Seheult mentions here how puzzled they were to see people who’s lungs seemed to be freed of the virus still or all of a sudden suffering from extremely low O2 showing symptoms of people in extremely high altitudes, suddenly collapsing and suffering strokes.
In a recent video a story was told of a young guy suffering from a stroke, and while the surgeon removed the clot, he saw new ones forming before his eyes on the CT scan.
Recent autopsies in Hamburg 🇩🇪 and Basel 🇨🇭 showed what sort of damage ACTUALLY killed people.
Most of them old men but basically all of them with artery issues, considered pre-existing ones but many might be new ones caused by this disease.
For some time now some German clinics have treated ICU patients with medication preventing clotting by default.
Don’t know if they did that as a standard precaution, due to findings or due to a ‘hunch’.
Probably because of China’s censorship.
This has been with us for a whole 3.5 months, so no, we really haven’t had time to really come to understand this disease yet. It infects the lungs and so, of course, that is where we started our exploration. We have known that men are more susceptible to death than women and this might be why. Men are, in general, more at risk of stroke and cardiovascular events than women in general.
We should test people who got strokes this year for COVID anti-bodies to see if they might have been caused by COVID.
They didn’t suddenly appear, you’re just now hearing about it. There was a consistent chunk of COVID deaths that were the result of cardiac events rather than pneumonia and sepsis. I think part of the issue is that it’s difficult to tell the difference between an event caused by the virus and one caused by the stress from your body fighting the virus. Now that there are theories as to how COVID could be causing these cardiac events, it’s being talked about more.
Information is noisy, especially during a global crisis like this.
They can’t see this but you can. High dose IVC, 25g, 50g and 100g when necessary. Also, high proportions of omega sixes to omega threes produces quite a bit of leakage in the electron transport chain, as fully explained in the following video: Omega Six Apocalypse: https://youtu.be/pHnPinYI2Yc Chriss A. Knobbe, Omega Six Apocalypse: From Heart Disease to Cancer and Macular Degeneration
Yes! Love this comment!
Med cram. Is the best way to truly understand this virus, the mainstream media doesn’t have a clue. 👍👍👍
I just HAD to pause the video just to say, again, THANK YOU for what you’re doing… we really don’t deserve your expertise…. thank you! I feel truly indebted. 🤗😃👍
It’s not a question of deserve. Having spent a few years as a lecturer it is clearly a calling for some. I can guarantee our dear doctor is motivated by doing these presentations and it shines through. This is what good will looks like.
With your videos I feel I am back in school 😷✊ Knowledge empowers ✔️
I seriously wonder when an actual definitive treatment will be found to completely negate the seriousness of the disease
Rustler V6 remdesivir
LEO (the lion) goes GER…loss of electons= oxidation. Gain of electrons =reduction.
I was wondering if any other old-timers would recall that mnemonic device from middle school chemistry class? And from secondary school biology I recall NLTPMMCH.
I’ve learned more in a few videos on this channel than I did in a couple weeks in college basic biology.
A G I have had the same experience but i think it has more to do with the fact that now, this info is tied to something that directly impacts your life, more than quality of teacher. Just a more direct interest yanno? For me at least this info now feels unbelievably important
Plus more fun. And so interesting!
These videos have been like a refresher course for me for my college biology classes, and things I might have only partially understood back then are now explicitly made clear to me. I wish my professors had been this clear back then.
Wish I could understand this. Is ACE-2 blocker BP med going to do more damage,.
@xponen_ I thought ace inhibitors upregulated ace 2. Meaning more ace 2. Lowers levels of angiotensin 2. From reports it protects lungs.
based on what he said, blocking ACE-2 will cause your body to produce more Free radicals that will damage your body & cause diseases.
If vitamin D is protective against CV, wouldn’t that help explain the disparity of outcomes between black and white patients (dark skinned ppl have less vitamin D)?
You mean, like in this study https://www.bmj.com/content/369/bmj.m1548 ?
Bernardo Cantu yes – my thesis involved looking at the attentuation of blood pressure during exercise in pts with hypertension taking ACEis – definite difference in the black subjects compared to the white subjects.
Also many white people are deficient in Vitamin D as well. In winter anyone in northern places -all of Canada, northern
US until you get really far south, northern Europe, Russia etc In the summer you have to have 15 daily minutes of enough skin e.g., arms and leg exposed (without sunblock) lol. Most Australians are Vitamin D deficient because they were encouraged to use sunblock all the time ! So everybody take a Vit. D pill.
Their ace2 makeup is different as well. Blacks are not to take ace 2 inhibitors.
Destitute yes!
I’ve been taking NAD+ supplements for 3 years now and I have definitely felt a difference.
You make complicated biological concepts understandable to the lay person.
Yep
This.
This is very concerning, which raises the question, will reopening the country (which we must) result in another peak in infections and knowing how this virus damages vital organs, will we have treatments to mitigate these life threatening symptoms?
It will because opening will mean more contacts and more spreading. But on the bright side scientists will have more data (including morgues). Because from this scheme we can see how it affects people with obesity and diabetes, but not healthy young people. Why some of them dying and others not? Is the difference only viral load? Blood types?
Can we nominate you for a nobel peace prize?
Maybe create the Novel peace prize for him too.
@E. Lee Yes, you are right. In the eligibility criteria (see link below) the tenth point is:
10. The prize is open to citizens of the British Isles or a Commonwealth country, or those who have been ordinarily resident and working in the British Isles or a Commonwealth country for a
minimum of three years immediately prior to being nominated.
But I’m sure there is an American equivalent (possibly more than one prize)
The eligibility Criteria can be found in:
https://royalsociety.org/-/media/awards/Faraday-eligibility-criteria-2020.pdf?la=en-GB&hash=11E885E95F6AE7CB7828BCCC5EB9BFE7
@ElvisTranscriber2 Yes, what has to happen to nominate someone? He is communicating to UK audience as I”m sure some people form there are following this. But does it have a more limited restricted definition, such as, within the UK?
The one for medicine, of course.
I don’t know if the criteria for the Nobel prize would apply here, but certainly a Faraday Prize is ABSOLUTELY in order.
The Royal Society of London Michael Faraday Prize is awarded for “excellence in communicating science to UK audiences”. Named after Michael Faraday, the medal itself is made of silver gilt, and is accompanied by a purse of £2500.
we’re figuring it outtttttt
Thank you for this immensely relevant content!
Please report on this insidious phenomenon. https://youtu.be/u6X5b8vehx8
Keep fighting tne good fight doc!