COVID-19 Update 64 with critical care specialist and pulmonologist Roger Seheult, MD on Remdesivir treatment trial updates.
Dr. Seheult breaks down two studies on remdesivir that were released yesterday. One remdesivir study was published in the Lancet (the study was conducted in China) and the other was published by the NIH (the study was conducted in the United States). The results of these studies on remdesivir coronavirus treatment vs placebo were dramatically different.
Links referenced in this video:
Johns Hopkins – https://coronavirus.jhu.edu/map.html
NIH – https://www.nih.gov/news-events/news-releases/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19
The Lancet – https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2931022-9
Some previous videos from this series (visit MedCram.com for the full series):
-Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress https://youtu.be/22Bn8jsGI54
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://youtu.be/fn2yk5SbGiw
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) https://youtu.be/NM2A2xNLWR4
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion) https://youtu.be/nO4xgcIaPeA
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
– Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
– Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?: https://youtu.be/kgzFAdYwYLM
– Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?: https://youtu.be/o8aG63yigjA
– Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: https://youtu.be/qc6VV7ue4cE
– Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: https://youtu.be/E7MufS6dnJw
– Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: https://youtu.be/fya6Zwxch88
– Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): https://youtu.be/uaIzj3s3p4A
– Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: https://youtu.be/JN-8bGB1cLM
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
Many other videos on COVID-19 (coronavirus outbreak, coronavirus symptoms, influenza, coronavirus epidemic, corona virus updates, coronavirus vaccine, boosting the immune system, vitamin D, vitamin C, Zinc, Quercetin, NAC, n-acetyl cysteine, Insomnia, PPE, hydroxychloroquine, ultrasound to diagnose COVID-19, coronavirus New York, COVID-19 and the epithelium/blood vessels) and other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com
Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at [email protected] if you are interested)
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MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus
In other words for every 56,000 people die, 2,000 will live. In other words, 54,000 die instead of 56,000. Hardly a good treatment.
Enjoyed the CME activity. This comment is off topic but related to the CME activity. I notice the diseases of metabolic syndrome DM HTN CVA CAD CRF vascular disease neuropathy are virtually the same as the diseases of the severe arm of Covid-19 expression. Metabolic syndrome is a disease of dietary induced Insulin resistance and is readily treated with a zero carb moderate protein high fat diet. It takes about a month to induce the biochemistry which restores insulin sensitivity. Going on a zero carb diet requires no medical intervention. It takes some time but may provide considerable protection to at risk patients. In addition it has bio markers which can be followed blood glucose and ketone bodies from a patient perspective and blood insulin levels from a physician perspective. A zero carb diet has a low V/Q ratio indicating a lower production of CO2 vs mole of 02 consumed also indicating a lower state of oxidation on a mole per minute basis. I’ve tested this using respiratory rate and vital signs using a tread mill and a standard format exercise protocol. Zero carb had lower BP lower HR and lower RR for the same exercise over time indicating a change in the biochemistry and physiology. I’m a retired CV anesthesiologist and Intensive care doc so I have more than a passing knowledge. If you could trim the 80/20 ratio to 90/10 by dietary change that might be a massive game changer Tnx for your videos
Thank you, 🙏
This whole thing is a one big mess. People were told to remain at home and ‘get over it’ unless they develop ‘pneumonia’. Now we know that at the more severe stage the main problem is endothelial damage subsequent hypoxemia, likely multiorgan damage/failure and thrombotic cascade with DIC waiting at the end. Remdesivir is not going to work for any of those, and is not required for those who get over this illness thanks to the ‘innate’ immunity. This needs to be looked at with a pair of fresh eyes.
Thank you Doctor
I know this is not COVID related, but i know you’re super smart! My sister was just diagnosed with a rare case of Trichosporon where the mortality rate is 70%. The doctor says he’s only seen one case his whole career.
Do you have any input on helping her get better. She has 3 young children and raised me and is basically my mom!!
what annoys me beyond belief is that if these statistics were for something natural, say vitamin C, or green tea, the medical industry would be going crazy, damning them. But here with Remdesivir they are desperately trying to imply that this is a good result. Grrrr
China was able to control the virus…..Bullshit…I really don’t believe most of this. Probably the last time I tune in and watch anything you say. My thoughts because I’m honest.
I missed you answering my questions on pathology of the corona-virus, when it is airborne, the origin, the pathways, where it enters polymerase stage…mouth/nose bind. Do you think that this virus in it’s entirety is capable of causing over reaction in the human organism’s organs, and it’s processes….like for example increased mucus…I do! But do you? thank you…CDH
Anything on convalescent plasma from what you have seen?
I Have the answer we need in covid 19
1 in 28 that test positive? Hospitalized? ICU? Please clarify
There is no such thing as “a number of subjects needed to achieve statistical significance”.
A CHINESE MAN HAD SEX WITH A BAT THEN OTHER CHINESE ATE BAT IN SOUP
I may be misreading the sources, but I think Dr. Seheult may have misspoken in saying that the U.S. study intended to enroll 1063 but cut the study short for ethical reasons. The press release says this is a preliminary “analysis” but says nothing about it being the results from only a subset of the intended number of patients. In fact, Clinicaltrials.gov (https://clinicaltrials.gov/ct2/show/NCT04280705?term=remdesivir&draw=3&rank=9) shows that NIAID’s ACTT trial was originally projected to have 572 patients so as to achieve 400 “recovered” patients, but they enrolled 1063 patients according to the press release. They cut the enrollment off early because they had more patients than they needed. Thus, despite twice as many participants as planned, they still couldn’t get p<0.05 on the mortality outcome. This suggests that the study was not underpowered; they simply didn't find a significant mortality difference. And thus, Seheult was mistaken in suggesting that maybe if they had completed the full enrollment they might have found the mortality difference to be statistically significant.
There are some curious things about the remdesivir news release! Possibly innocent, but curious nonetheless. Dr. Fauci and NIAID have worked with Gilead Science for many years, as they developed remdesivir for Ebola, MERS and SARS (that work is stated in the NIH press release). Gilead supports 9 of 50 of the expert panel who released the latest CDC treatment guidelines that downplayed hydroxychloroquine (HCQ); the next closest company was Regeneron with just 2 relationships (https://covid19treatmentguidelines.nih.gov/panel-financial-disclosure/).
It is also curious that Fauci rushed a news release on the same day the negative Chinese study was published in Lancet. That being peer-reviewed, it is obvious the rush wasn’t the other way around. Did Fauci and Gilead want to preempt the negative news from that study to keep momentum rolling on remdesivir? It seems likely that they knew about the pending publication (the trial is on the clinicaltrials.gov website so was no secret, and Gilead provided the free remdesivir for the trial so was probably kept apprised of progress. Also, it wouldn’t be surprising that the publisher or one of the peer reviewers might have let NIAID know the publication date).
Fauci claimed in an interview that he released the findings yesterday due to concerns about leaks and also from ethical concerns because he apparently thinks the results are strong enough that this should now be widely implemented. Not only will that undermine trials of other candidates like HCQ, but it proves that they did indeed rush this news release, by their own admission. IF their concern wasn’t leaks or ethics, but being undermined by the Chinese report, why would they care about a negative report from China unless they had a vested interest in remdesivir’s success? Otherwise, as scientists, they should welcome all additional data. (Here’s Fauci’s interview as reported by Reuters: https://www.msn.com/en-us/news/us/fauci-says-leak-concerns-fueled-his-white-house-revelation-of-gilead-drug-results/ar-BB13p19Q?ocid=spartanntp). Note that Fauci called for patients on placebos to be switched to remdesivir! That prevents many additional questions about this work from being answered. As an accompanying Lancet commentary on the Chinese study said, “the temptation to lower the threshold of convincing evidence must be resisted, because adopting ineffective and potentially unsafe interventions risks only harm without worthwhile benefit, while making it even harder to undertake trials to find truly effective and safe interventions.” (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31023-0/fulltext).
So why are Fauci and NIAID so vested in remdesivir? I don’t know. Are there financial relationships? I hope not! Has the long-term relationship between NIAID/NIH and Gilead resulted in enough revolving door personnel transitions that personal relationships bias NIAID objectivity and neutrality? Is it political–the need to justify NIAID/NIH’s massive budget and their existence to Donald Trump and the American people, by showing that “their” study found a “winner” and they are defeating this virus (especially after having supported research in China that some allege produced or released the virus in the first place)? Lots of questions remain about this story!
Conclusion: although not as efficient, placebo is cheaper and has less side effects. Now try Remdesivir vs anti-oxidants, zinc and Quecertin at early onset vs Placebo.
Dont believe china they are total b. S.
What do you think about this update in the link below
https://www.medrxiv.org/content/10.1101/2020.04.17.20057125v1
How can we believe anything out of China?
??? ??? ??? LUMBROKINASE ??? ??? ???
Dr Seheult, I wonder if the presence of OSA Sleep Apnea could explain some of the younger patients coming in for COVID. Sleep Apnea aside from reducing the amount of restorative sleep for the immune system also decreases NO production and increases oxidative stress with higher ADMA https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438195/
Thankyou Dr Seheult, for all these updates. I have been following these since January with great interest. I like the way you also talk about alternative medical techniques that may help. How you find time to make these videos I don’t know, but we really appreciate them. Your diagrams and explanations are very clear, and you talk at a level that even every day people like me can understand. From these updates I began learning more about cell respiration and virology. It is a great source of information that I can trust unlike mainstream media. Thanks for invitation to CME live stream Webinar. Keep up the good work. Stay well stay safe.
And we believe China….. ?
Did they really run out of CCP virus patients? Places are in lockdown this very day, border to Russia has active cases….. nuff said.
Thank you for data driven results and info.
They should open source this. That is a big enough effect that everyone should have access. We should make tones of it.
Thanks doc for the update
in the nucleus of the cell we have our immunity and control over all functions of the body as our innate ability and our environment is effecting this ability, also dim 2 patients are likely to not recover because the intake into the cell is very limited by the fatty layer. Metabolic symdrome and body hair pays a part as well. dpctprs meed to start doing glucpse tolerance tests and also prioritizing triglceride level or ww will see a lot of suffering from this type of lipoid pne
By the way thank you for all your great information in all of your videos. This has allowed me to make an informed decision on how I want to be treated if I catch the CoV2 virus and it will not be redemsifer. One person out of 28 survive… That’s bad numbers.
They don’t care about actually curing patients and saving lives they only care about Trump not getting credit and them getting filthy stinking rich! Remdesevir cost $1,000 a pill. Chloroquine cost $0.63 a pill.
French study on chloroquine and zithromax.
At day6 post-inclusion, 100% of patients treated with hydroxychloroquine and azithromycin combination were virologicaly cured
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102549/
Hold on a second, they want to push this drug even when they haven’t met the target, and they are dismissing hydroxychloroquine without a controlled study??
exactly. hydroxychloroquine was pressed down to promote a more profitable option.
LovethisNation – Imagine if Dr. Fauci had endorsed hydroxychloroquine and President Trump had endorsed remdesevir. It’s likely remdesevir would be heaped upon the junk pile of failures while hydroxychloroquine would be pushed to succeed at all costs. Is it too much to ask to see them both either succeed or fail based on good science? It would be a shame if hatred of Trump was enough to dismiss a potential COVID-19 treatment without a controlled study.
This series has been greatly beneficial. Could you also kindly cover the purportedly 3 different strains of COVID19: the weak strain “S”, the more potent and stronger strain “L”, and new one being reported as strain “Y”. I have no idea what their differences are and the strong “L” stain is suspected to be the one that is hitting most in Italy and in US East Coast. I was wondering if you have any relevant facts and research on this.
SARS-COV-2 attacks body in multiple key-lock mechanism. A combination of drugs is needed to be effective in treatment on various stages of disease progression.
As a British health spokesman said this morning, most likely, a “cocktail” of drugs will most effective in treating COVID.
So 27 people die and one person lives giving the Fauci-endorsed Remdesivir. Doesn’t sound too effective to me, I think I’ll stick to my quercetin, zinc, and Vitamin C. Or maybe just maybe my doctor would speak French and have the sense to give me hydroxychloroquine and zinc. Guess it’s too cheap to warrant a clinical trial, though. Big Pharma – never let a good crisis go to waste!
I’m sorry but the study should have been allowed to complete. There is good science and there is rushed science and they don’t often make good bed fellows.
So out of the unofficial studies of treatment with chloroquine and zithromax on thousands of patients there has been zero deaths. And the medication is much cheaper than Remdesevir.
In case any of you are interested in the French study on Hydroxychloroquine and Azithromycin: https://www.mediterranee-infection.com/wp-content/uploads/2020/04/azithroquine_manuscript-soumis.pdf
Love your work Doc, best wishes from West Oz. 😷👍
In lancet, the group that got remdesivir was of more severe patients on average. More on mechanical ventilation.
To my opinion the only way to rationally explain the sudden die out of the epidemic in China is a secret medicin or vaccination or they simply lie about it.
They lie a lot
Weird to stop the study right at the point it has nice outcome. Really not very rigorous from the statistical point of view. The outcomes are not credible at all.
Sir can the variation in between 2 studies could be due to strain in those patients ? I mean s strain in china study and l strain in NIH study or vice-versa
Awesome video! Thanks for the great content! We just put out a video on COVID-19 and hypercoagulability. How SASRS-CoV-2 increases the risk for both macrothrombi like pulmonary embolisms and strokes, as well as microthrombi. We would love to hear what you all think about it! Linked below:
https://www.youtube.com/watch?v=L6Cyfzy3xiY&t=356s
Cheers,
WBDR
Difficult to trust anything from the US right now.
The mortality result didn’t achieve statistical significance and could be due to chance. There may be no clinical benefit at all from using remdesivir. I’m highly suspicious of the way the inexpensive and, up until now, very safe drug hydroxychloroquine’s been pooh poohed despite very promising results in France and Brazil, whereas remdesivir is being hailed as a success despite lacklustre results and high rates of adverse side effects. By an amazing coincidence one makes the pharma companies pennies and the other thousands per dose.
I don’t believe anything related to this virus if the data source is from China
Remdesivir is an adenosine nucleotide analog
Cordycepin is an adenosine nucleotide analog
Both antiviral
Cordycepin is from cordyceps mushrooms
Does the use of Prograf, and CellCept make you more susceptible to Covid?
So the P values are not calculated to support this particular way of interpreting information, but it is my impression that sure, you would have to treat 28 to save 1, but that is one of approximately 3 that would have died without treatment.
So, it’s not saying 27 died, and one lived, but that 25 would survive, and of the remaining three, only two die now. 8% mortality is still conspicuously high as an absolute value, however.
How can you believe what China says on any topic related to COVID 19 without duplicating the test? It might be in their interest to sway such treatment (imams not being judgmental here, this is a trust issue).
Thank you Dr. Seheult
The more you know: https://youtu.be/SwtTxgxYPEk
i don’t believe china at all. we need to do our own studies
Please explain NTT=28? How can you save 1 in every 28 patients when this his higher than the mortality rate?
There are double blind animal tests with remdesivr and is awaiting more peer review.
Does it just speed up the recovery time for people who were going to recover anyway? Helps hospitals treat more patients I guess so worth it. I’m mostly optimistic though because China says it doesn’t work 🙂 Stay safe everyone.
First time during this whole thing something feels like good news.
All the anti-Chinese comments below. Remember folks: (1) The CCP needs healthy Americans with money to buy the goods they export. (2) If Covid bankrupts a country (any country), then China’s loans to that country default. China and the CCP, just like the USA, have strong monetary reasons to push for good health and prosperity in customer nations.
👍👍👍
Thank you for taking the time and making the effort to present these vids. I try to watch you everyday. I developed full blown GBS in 1977 after a double dose of the swine flu vaccine. It took 1 year to 80% recover. I am worried about what is going to happen now. Good Luck to Us All, Rick
There is too much money in all this…
So who should we believe, the country that copied remdesivir or the country that are trying to sell us for the 5th time a 1000USD drug ? I’m confused, can we get a non-related third party country doing this study?
if only the NHS in Scotland was doing anything for the ill
Can you please find ANY study that tells WHEN they started treatment?
Mortality of hospitalised co-19 patients in the Nederlands is 8 times(8×)! higher than in Germany . What is the difference in treatment? Anybody?
euthanasia is legal in the Netherlands?
_Good news, in six to eight months plus._ From Gilead, the company that makes Remdesivir:
“The production of remdesivir is a long, linear chemical synthesis process that must be completed sequentially and includes several specialized chemistry steps and novel substances with limited global availability.”
“Over the last several weeks, we have also worked to shorten the manufacturing timeline through process improvements. The typical timeline for manufacturing a drug like remdesivir at scale is nine to 12 months; we have reduced that period to six to eight months.”
Here is the link to the webpage I got that exert from: https://www.gilead.com/purpose/advancing-global-health/covid-19/working-to-supply-remdesivir-for-covid-19
Brainwash treatment update…
https://youtu.be/yAO0NN-bcAQ
…..they brought the outbreak under control so quickly….Hilarious. It is out of control right now in guandong.
Your briefings are outstanding.
Could be interesting to find the same numbers of patients with hypertenstion on ACE inhibitors plus remdesivir
From the time that money has num 1 priority, forget the threatment….
If all my neighbors default, my house is worthless. So what I’m expected to pay mortgage on a worthless property to a bankrupted company?
Saving lives is the ultimate test of Remdesiver. But as someone whose experienced a moderate covid-19 infection I’d have a second standard. The virus digs into your body and reemerges several times before its cleared from your system. Those relapses have been proven by Korean doctors, whom are now saying their patients did not become reinfected, but rather experienced relapses. I completely agree as that’s been my experience as well. The relapses were always preceded by spikes in my blood pressure. I’ve received minimal medical attention, some prescription help with breathing, prednisone and an albuterol inhaler and something to bring my blood pressure down during a second trip to the ER. Through the entire infection (I’m now in week 6) I never felt entirely great, so relapses werent a surprise. I’m interested to see if Remdesiver actually stops the virus in 14 days. The Chinese study makes more sense to me with its 28 day length. I’m curious to see if the US patients relapse or not. And if their blood pressure spikes later on, after they’ve left the hospital, or if they experience any relapse in symptoms at all. That would be my second standard, whether or not patients are spared relapses.
Thank you Flora, this is such important information.
No official information tells us how the virus attacks after you think you recovered.
I heard of two other covid 19 patients who cured themselves at home. They both had two waves.
One had mild covid 19 and now is suffering from severe cough.
All the best for you
Remdesivir looks like a total BS. How do they measure time to recovery? How this time is affected by general patient’s health?
This is a big deal?? 14% mortality in the Chinese Study(insignificant vs placebo) and then 8% in the follow-up U.S. study where basically they cherry-pick otherwise healthy patients in the early stage of the disease?
I might not be understanding this correctly …but having seen the clinical results from Dr Raoult in Marseille Fr – where less than .15% died, only 4 deaths in 2600, one has to wonder why we are not already treating patients with HCQ outpatient early on. Unless the objective of Fauci and the NIAID is not saving lives – but instead qualifying a very high-cost minimally effective U.S. drug that must be administered in the hospital. This later scenario keeping alive the drive towards universal mandatory vaccination – this decision entirely under the approval of Fauci and NIAID – including the lucrative research grants and the funding he controls.
No kidding. It certainly _seems_ like that. And with the corporate “news” media too.
If I weren’t at work right now I would be at that webinar.
A study coming coming out of China? The results are likely to be within the parameters determined by the official CCP party position on the matter.
Looks like the live webinar is a not going to happen today due to technical difficulties.
thank you MedCram
Anyone able to see the webinar? Tech difficulties say ‘see published agenda for broadcast time’? where?
I Love your videos and how you are on the frontlines with this virus. Keep up the great work and stay safe. 😀
I have been trying to get this idea out there but nobody listens to me!!
Aminaphtone will solve the problem!! Aminaphtone to stabilizes endothelial cells and avoid release of endothlin-1 and many other factors such as ELAM, VCAM and ICAM,all those factor are linked to anti-phospholipid antibody surge in the body. Aminaphtone also reduce levels of TNF-B and IL-6. Cheap, low toxicity and very few side effects. Please listen to me!!!
Some articles to support my claim
https://doi.org/10.1016/j.ejphar.2016.04.018
https://doi.org/10.1016/j.clinthera.2008.05.009
https://doi.org/10.2165/00126839-200809040-00005
https://doi.org/10.1016/j.ejphar.2011.05.060
DOI: 10.1002/1529-0131(199805)41:5<800::AID-ART5>3.0.CO;2-J
DOI: 10.1016/j.atherosclerosissup.2017.05.039
I wonder if the results in the China study would have been different if Remdesivir had been given earlier in the course of the illness. My understanding is that antivirals work much better when given as early as possible.
“Studies” manipulated. Not real science… Yes, were Are to question real science, credentials and authority after all, esp when all tied together and hiding facts and forbidding questioning constant Con-tradictions.. One study on Remdesevier already showed worse results with it, using raw manipulated methods.
What happened to the endothelial update? Would a statin be protective?
There is no science behind statins. They are poison.
Please explain how this Ebola medication helps you deal with ” the endo/epi thelial ACE-2 invasion ” . I would be much more interested in your case work on oxygen and clotting. Stay on the track you are on and “beware of the Remdesivir.”
China brought the virus outbreak under control my ass.
Hello from Hong Kong, I’ve been watching your updates since late Jan
So the NIH and FDA are pushing hard on Remdesivir – an expensive patented drug – but they are not interested in comparing it to hydroxychloroquine + zinc + azithromycin, which are generic drugs, in equally-careful studies?
This is problematic. It’s not enough to show a very modest benefit for Remdesivir. We also need to see that it outperforms generic drugs.
What else is missing from the NIH and FDA approach? I’ll tell you. We’re discussing antiviral drugs here. Antivirals are most effective if given early – before or soon after onset of symptoms. They are far less useful if administered in ICU, after the virus has already exploded into severe disease and heavy viral loads. The true value of antivirals against COVID-19 can’t even be seen unless they are administered early.
What we *really* need is an inexpensive, over-the-counter therapy with very low risk that people can obtain and use.
NIH and FDA are not leading in a direction that best serves the public’s interests. But Gilead’s shareholders are ecstatic. Big Pharma is the true beneficiary of the NIH and FDA policies. I call that ‘corrupt.’
Yes, but parachute treatment must be administered prior to contracting the whole dancing with gravity virus.
Please include discussion of side effects, also important in treatment decisions is the numbers needed to harm
it’s just amazing that some people still believe the CCP data. We should send China back to where they were just a few decades ago (before the greed and treason of western businesses & politicians made them rich and dangerous): one bowl of rice per/person/day .. Pull out the western businesses from China and boycott their products and services! Make them pay for their crimes against humanity! Identify the western idiots (businessmen and politicians) who licked Chinese arze and herd them up for a Nuremberg-style trial! And STOP advertising the CCP’s LIES!
Malaria drugs and HIV drugs are working against this virus seems that this virus has malaria strains and HIV strains. This is a man made virus.
Ehm… that’s a big leap in logic. Let’s say that you have disease A (for example an open wound). I can treat you with drug 1 (for example an antibiotic) that is also used for disease B (say, bacterial pneumonia). I can also treat you with drug 2 (say, a rinse and a bandage – OK not a drug but still a treatment) that is also used for disease C (bone fractures). It doesn’t mean that you necessarily have diseases B and C. Only that drugs 1 and 2 have secondary mechanisms of action that can partially overlap and improve your outcome.
Thank you.
Man, you were all over this! 31 episodes ago.
Any word on ivermectin? I know a doctor in FL was using it with great results.
Can’t believe a word you hear out of China…it’s all the approved propaganda of the Chinese Communist Party….even if in The Lancet.
Remember to pray harder for world healing. :'( We need to heal the world.
Keep praying for world healing! Let’s fight the corona virus together!
To end this madness, I suggest using your free computing-power to fight COVID-19.
PC: [email protected] Smartphone: dreamlab
Hey Doc. please give me that pill that has a 1 in 28 chance of helping me out. WTF kind of update is this after 6 months into this f’k up?
Modern medicine & health system have a looooong, long way to go, or do they?
Solution(s): start with granular data acquistion on a global scale inclusive of monitoring (biohacking) and subject it to algorithmic analyses, akin that’s been for decades now done by telcos, infrastructure or logistics systems, etc…. Everyone and anyone should be availed to opt in as the tech is available, cheap, easily deployable, scalable as is the professional and intellectual capitol.
Data is where it’s at vs this complete data chaos UTD for lack of better words, is what will ultimately deliver viable prognoses and treatments and NOT YOU, NOT THIS WAY, rest assured as we wouldn’t be here now, or would we?
Same applies to socio economic policies (formulation of which rely on your expert recommendation) that are neither sustainable nor adequately executed in EVERY respect particularly in context of mental health(and everything that stems from it) and certainly not felt in the least by medical related workers or the government because the extenuating demand – which begs obviousb sleuth of conflict of interests and job protection questions. However, the longer you guys continue your BS the stronger the testimonial in support of the argument to the lack of your due responsibility, vision and/or initiative and, as your ongoing “efforts” will be viewed as futile at best in retrospect(should you choose to continue your MO) as are nearly ALL practices in your industry by your preceding contemporaries compounded by just staggering examples that continue till this day and aside from malpractice.
Respectfully, wake the F’k UP people and do what needs to be done as aforesaid herein! Other than that, thanks for your services, sincerely.
QUESTION:::::: Does Dr. Anthony Fauci and/or B-ILL Bates own positions in Gilead stock??
Which strain of the two or more was suspected in the China study? Could make quite a difference when comparing its results to the later study— especially with different co-morbidities
involved in each. Sounds more like “any port in the storm” at this point. Also sounds like big-pharma at work in the wings— as in– where was the zinc in those HCQ-Azithromycin studies?
More self-serving data from China.
Remdesivir is an expensive drug produced by Gilliard, a major pharma company. Gilliard will significantly financially benefit from Remdesirvir’s use. HCQ is embarrassingly cheap. Follow the money.
@Dglas Raeat there is no science, and if there was, studies can be manipulated, same with statistics.
Follow the science instead. We will do what we have to, whatever the cost, or many, many more people will die.
Your parachute treatment example was rather interesting to me…lol. I sure wish the NTT was 1 in reality.
I am not sold on Remdesivir.
I wanna see a triple blinded study with more participants. N~5000.
I hope it happens..
It sounds to me like the pharma company Gilead is pushing this drug for financial reasons.
That’s because hydroxychloroquine does have major side effects and can cause heart issues.
Du hast völlig Recht!
Yeah, I feel the same, they are doing exactly the opposite they did to hidroxicloroquine, they were just saying more studies need to be conducted because the side effects bla bla bla but with this drug looks like they are not question it too much… they just pushing it to be used as soon as possible even when the results are not the best….
Just going out on a limb here, and saying that what evidence Remdesivir does have at this point was classified as “no evidence” for other drugs.
You are not alone in that. The over reliance on p values is also very worrying. Statistics are readily manipulated to achieve the desired result. Ultimately the mortality rate is the prime variable of interest, and it was not exactly the earth shattering success hoped for.
They should do Remdesivir WITH Hydroxychloroquine+Zinc, that way everyone is happy. Patient gets better AND big pharma makes it zillions. Win win!
@Ich Dien Do they? I actually heard this suggested so I am genuinely asking.
Unless the two drugs interact with each other and become highly toxic…
“because the outbreak of covid-19 was brought under control in China ” yah because Chinese numbers thanks to the CCP are so reliable.
The UK government has even stopped mentioning their claims because of obvious reporting issues.
He is being courteous to other doctors who did an early study in the middle of chaos.
So have the Germans.
I really hope you don’t believe China’s numbers!!
These are double-blind studies. So the numbers are independent of reporters.
Imagine being so mentally deficient that you cannot comprehend that sometimes the US system is not superior.
Innox GTX Yeah China underestimates & the US over estimated numbers
@Innox GTX it’s randomized trial. That means the patients and the doctors don’t know they are being used.
And don’t believe the american numbers. because the outcome is to iportaant for this company for greeeeeddddd of dollars !
It seems then, that we have conflicting results. Amazingly (or not so much so) Fauci praises one study and ignores the contrary. Soon we will have “concensus” that such are the facts and all evidence or facts contrary to “consensus” approved facts will be damned, ridiculed as denialists, or ignored altogether. Scientific method vs scientific “consensus”.
What is needed here is someone outside of these interests to reproduce the same findings. Since reproducibility is a staple arm of the scientific method.
I bet the last positive study was fudged, by fooling around with the distribution of patients among different countries.
That one study of ivermectin showed much more powerful results than this.
thats what they are going to give to the rich people, this remdesivir study is essentially inconclusive ..
Nationalize the production
Remdesivir = $$$$$$$$$$$$$$$$$$$$ Hydroxchloroqui $
@medcramp what is your thoughts on vaccine developed by oxford in large production in india
ChAdOx1-nCoV-19
do you think its effective enough?
source: https://www.businesstoday.in/sectors/pharma/astrazeneca-oxford-university-team-up-to-develop-coronavirus-vaccine/story/402500.html
The “problem” with Sars-cov-2 is that it is a quite mild disease that will spread enormously. It looks like it has nothing to do with the much more lethal SARS and MERS infections that died out after their few hosts contracted it.
Ich Dien again I do not disagree. That’s correct. Nevertheless, you have to admit that the vast majority of infections end up asymptomatic or with very mild symptoms and that, in my book, stands as a mild disease.
@C_R_O_M__________ It has much less to do with mildness than with incubation time. A disease could be 100% deadly and still spread if people are infectious long enough before developing symptoms. Especially in an era of mass air travel.
Ich Dien I don’t disagree with that. That’s pretty accurate apart, maybe, for the word “significant”. We shall see about that in the end.
@SpectatorAlius Maybe you didn’t understand what I wrote. Let me rephrase it. If it WASN’T mild it wouldn’t have spread that much (by definition). Very serious diseases with very acute symptomatology end up killing their hosts (hence they don’t spread as much – just like SARS – MERS). This is not debatable this is a fact! Conversely even the common cold will be very serious for certain people that doesn’t make it very serious for the general population.
@C_R_O_M_______ That is a very misleading description of the disease. Sure, *most* cases are mild. But an unknown percentage (initial estimate was about 1%) turn very serious, causing Acute Respiratory Distress, heart attack, stroke, or cytokine storm.
Also, our belief that many people had he disease and never knew it is based mainly on the antibody test. But we *still* do not know the rate of false positives/negatives for this test!
QUESTION: Gilead produces PREP medicatiom for HIV. This medication, taken daily, acts as a “de facto vaccine”. Are they looking into REM as a PREP for COVID? Makes more sense as a RNA transfer inhibitor to treat before infection.
I’m not impressed by Remdesevir results. This is just a tiny little bit better than a placebo except it’s much more expansive.
It targets the enzyme on the receptor witch blocks the virus. And that is good progress.
Interesting, not to mention the PPE and hospital bed savings with 4 day shorter stay in hospitals.
Not about the drug itself, just warn everybody that anything out of China is not to be trusted. Guess we’ll just have to wait for more data for this drug to know whether it really works as Dr. Fauci believes.
You are naive to believe any study done by the Chinese.
Agreed. And big pharma is to be trusted implicitly?
Here is another study being done in Canada on the drug.
https://www.folio.ca/u-of-a-virology-lab-finds-drug-originally-meant-for-ebola-is-effective-against-a-key-enzyme-of-coronavirus-that-causes-covid-19/
Thank you for your continued commitment to education on this virus. Knowing what what is happening in the world, and the continued fight against this situation, lessens my anxiety and fear about this changing new world.
Stay safe, be well
Proudly 🇨🇦
Fauci is pushing this drug without proper clinical trial.
You have things backwards: the ‘proper’ test is *not* a “clinical trial”, it is a double-blind randomized trial. Which we now have. Unfortunately, the sample size was too small to be really conclusive.
This is not very impressive for such an expensive drug . Take for example antibiotics. People with say an infected hand from a cut would likely all be cured by a round of antibiotics. Close to 100% efficacy except for those allergic to the antibiotic. That is a treatment ! These wishy washy conflicting ” studies” make no sense . It either kills the virus or it doesn’t . Which is it ? Very frustrating .
Of course, had the NIH study completed, the mortality rate could also have shifted in the other direction, ending up similar to the study in China that was completed. In that study, you noted that more people died in the remdesivir group. It seems the mortality rate may be about the same, and depend on how early the antiviral is started. At an expected $900+/dose, the question becomes how many people will start it early (when symptoms are generally mild and most are expected to recover anyway)? Of course, once symptoms become severe, it may be a small price to pay, but that is precisely the point when, according to the studies, remdesivir actually increases the chance of death.
Remdesivir side effects include respiratory failure, liver damage, anemia, and thrombocytopenia. Adverse reactions noted in the Chinese study were similar in both groups, with the exception that thrombocytopenia was only observed in the remdesivir group. Perhaps the doctor can explain if thrombocytopenia, which would seem a good thing (per Update 61), could be bad in late stage COVID-19? (eg., any medication adminstered to treat the thrombocytopenia, or the body’s reaction). If clotting is already a concern, and the body is conpensating for thrombocytopenia, what happens if remdesivir is suddenly discontinued?
More evidence that the lies coming out of China are harming everybody else!
what’s wrong with you?
I am curious to know if there are any human trials of ivermectin.
There are..
https://www.youtube.com/watch?v=8Z1Oc4_99sk&t=259s
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3580524
Mortality rate for single dose 150mcg/kg oral ivermectin was 1.4% Vs Placebo 8.5%
*****more important*****
Dr Raoult treated over 1061 confirmed COVID19 patiente HCQ+AZM 3 days .49% mortality rate
5 days HCQ+AZM+Zinc <.01% mortality rates when given before severe symptoms develop. So i you can't get HCQ+Azm, eat 2ml of 1% animal ivermectin on some bread. You will reduce your chance of death from 8.5% to 1.4%. Don't worry the medical industrial complex has said not to treat yourself because reasons.
https://www.youtube.com/watch?v=bdAq_NXRku0
Doctor, I have been viewing your videos and respect your work. I have a nagging thought that pharmaceutical mega corporations are pressuring scientists/organizations to test anti virals that will be cash cows for the pharmaceuticals as opposed to really cheap anti virals that may work as well or even better, i.e., hydroxychloroquine…just a thought for you to consider.
What was the number of patients in the US trial? The Chinese study also showed viral load vs time for both the Remdisivir vs. the placebo, and they were the same. Amazing Remdisivir is getting the attention and how fast Dr. Fauci jumped on it to promote it.
The trial had a cohort of 1100 hospitalized patients from the US, UK and countries in Europe.
China study is Useless. CCP will Not allow the truth. either what works or how many deaths.
Nice cope ur telling urself. China has little to gain from their study. They also were the ones to promote chloroquine as a treatment and Trump/Republicans promoted it like crazy. A large 2600 sample randomized study in France showed HCQ works and yet HCQ gets no love. The china study was also published in the Lancet, so it has some merit. Even if remdesivir works its a lot less effective than HCQ.
A 1000$ dose that will probably not be covered by Insurance (not approved) that will be payed by patients, also highly ineffective, times a couple of hundreds of thousands equals hundreds of millions in profits. Cha-ching!
Catalin Pop It’s $2000 for a treatment regimen. They’ll probably have government guarantee payment.
As a layperson I totally understand and enjoy your posts. I however, do not trust anything that comes out of China!!!!!!
@Redwood Madrone Luckily, China is not a race, it is a country. And the Chinese Communist Party, which is responsible for “anything that comes out of China” is also not a race, it is a repressive socialist dictatorship.
twat
Data from China is BS.
@Redwood Madrone op isn’t racist either but okay cool
Douglas Robbins
Luckily, science is not racist.
When you do a google search of remdesivir, none of the sites speak highly of it’s effectiveness on covid 19. (That is unless they have taken them down).
neither do 2 trials explained in this video. no miracle cure.
Many thanks for that quick update, I know you must be busy with preparing the 4 PM live seminar. See you then!
5g, CORONA, MERCURY. https://youtu.be/B-iDL2VP9Yk
The main differences between the Chinese study and American study in determining outcome were apparently FDA RULES and STUDY FUNDING. The American study could have easily used FDA rules to eliminate 1 in 15 study Remdesivir fatalities as “poor candidates”, tipping the balance in favor of the self-funding drug company.
Aspirin, seems to me, if taken before infected will prevent blood clots caused by covid-19
You are better off taking zinc, vitD3, vitC, quercetin and NAC for prevention. Drmedcram takes it for prevention and he is around covid19 folks a lot more than us and he hasn’t gotten sick.
It would also reduce fever and thus potentially the efficiency of your immune system. A lot of trade-offs to be made with limited information.
We’re very fortunate to have your wise analysis!
I wanna step into a time machine, go back 2 years, and enjoy the heck out of the summers.
Gerald’s Videos you’d do much better if you’d shorted the markets on December 2019! There are going to be a lot care-free summers to come. Don’t worry about that!
Im gonna have to disagree with the idea that china had this under control quickly
Also i wouldnt trust anything out of china at this point
What about alpha lipoic acid, silymarin, and selenium treatment?
Parachutes have to be packed and used correctly and presumably there are faults in material and production too, so they don’t always work, but they are always a better risk than any alternative it would seem to me anyway.
What was the number of days that the patients had symptoms before getting remdesivir?
For those kind of answers you have to read the paper. He is giving a very short summary.
They said severe …..trouble breathing too
Vicks vaporub has camphor.
They should have let the study run until it met the fatality reduction endpoint. Saving someone 4 days in the hospital is nice, but it doesn’t seem essential enough to not get confirmation of fatality reduction that would benefit the whole world.
CCP data is flawed to say the least..
Remdesivir looks promising in trials..ido hope we can get the vaccine soon..too many people are very sick and dieing all over the world….I’m from Ireland. Thank you for your updates very informative all the way through this pandemic
A little over 3% improvement in mortality outcome = NOT A CURE
@Ich Dien It does if it’s you or your family.
@Kathy Sharp Relative improvement is not very meaningful. It’s the absolute values that count in the end. Imagine a hypothetical disease that kills 999 people out of 1000. If after giving a drug you have 998 dead out of 1000, yes, you have doubled the positive outcomes, but you can’t say that you have a cure.
Nothing Is a cure. Is there a cure for the flu? If this eventually gets cured or eradicated i will be impressed.
@Kathy Sharp what’s with the 31% I’m hearing?
11.6 / 8 = 1.45. It’s 45% improvement.
In the US study when how far in to the illness or the severity of the person’s illness was Remdesivir given?
I see that was given in the China study. Was it not recorded for this one? That seems like very important variable in this illness.
I think it’s also why hydroxychloroquine didn’t show too well in the studies I’ve seen, it was given too late. I’m just a layperson her but seems to me Remdesivir was given earlier in the US study than the China study, hence the dramatic difference.
Why can’t hydroxychloroquine get a fair shake here? Just thinking to the world. Thank you so much for the videos!!
Because Trump mentioned the original in vitro study & we all know that Orange Man Bad so naturally the opposite is true.
zendoquien because it doesn’t go with Government and Corporations corrupted “narrative” as they get bailed out and exploit their “control”.
Waiting to watch at 1:30am here from Sri Lanka!
Is there a way to stop the virus from attacking the blood vessels? If you are positive for covid19 and you are sent home what should be done stop chance of clots / damage to blood vessels?
chemically Remdesivir look pretty mutch like hydrochloroquin….. Same chemicals structure slightly different..
I read this somewhere else but couldn’t find much evidence for the difference in mechanisms. Is there a reference you could post so I can do more research on this?
Why not treat it with Atovaquone and Z PAck?
So this means there still no guaranteed treatment until today. Maybe herbal medicine can help, like garlic, lemon and honey.
I noted that artemisia annua is being pushed by the Government of Madagascar. Wormwood but not the European herb. I don’t like the look of it,though. It looks dangerous. Garlic is an allergen ,too.
Garlic, lemon and honey are also not guaranteed treatment. In fact, I would have to examine my entire … well let’s just leave it at that… if it turns out that ordinary food items have any significant effect on COVID-19
the improvement between 11.6% and 8% is actually 31%. People treated with remdesivir are 31% less likely to die than with the placebo. I don’t think you should subtract percentages like you did at the end of the video.
Mohamed Belhadj the formula calls for absolute risk reduction, the calculation is correct
@Ich Dien after reading your comment and other comments I understand that the number in the video is correct and what it means. But my Math is not wrong people treated with remdesivir are 31% less likely to day than without remdesivir. In your example they are 50% less likely to die but they will most likely not die anyway.
@Mohamed Belhadj Your math is wrong. For example, take a hypothetical, mild disease that only kills one person every thousand. Now imagine that you find a drug that halves the mortality, i.e. one death every two thousand. According to your math, since the effectiveness compared to nothing is doubled, you would conclude that you need to treat 2 people to save 1 life – which is obviously wrong since those two people would have had 99.8% chances of surviving anyway. Instead, in this example you would have to treat 1000 people to have a 50% chance of saving one life.
@Howard Lester when you buy something for 11.6$ and you get a 31% discount, you will pay 8$. 11.6 * 0.31 = 3.6 then 11.6 – 3.6 = 8.
Please explain. I am interested in your math
does remdesivir (which could be very expensive) have “negative side effects” on par with HCQ + azithromycin?
has a study on Zn + quercetin been completed?
I might have to get out my tinfoil hat, but I’m wondering how much economic incentive is behind these studies.
@Nona Cee You need to look beyond the US. Studies around the world are being conducted. The fixation that Americans have on the gov. and either pro or con does not enter the discussion there. Second pharma suspicion again American centered view. Pharma operates differently in many of those countries as well.
@Ich Dien yes it was safe and effective up until a month ago when the media decided it wasn’t….. anything to be contrary to Trump.
Another agenda going on.
@Ich Dien You are right and I have read that Remdesivir has more side effects
we will have to see once some double blind studies for these meds you mention are completed. several are already underway with the compounds you mention in various combinations.
HCQ has been used like forever to treat malaria in poor countries and until a month ago it was always considered a remarkably safe drug.
Could political bias be infiltrating the talks these days? Careful. Volumes are spoken by subtle implication. Don’t play with lives. Let science do it’s job and keep the “talk” out.
I have watched daily since Dec. 2019 and appreciate info. Watched Sunday Webinars too, so i think I’m realively aware of things here. Noticed Loma Linda was treating patients with H. & Zpack combo. Coincidence? All doctors just agreed this was the way to go? I don’t care as long as something really works and people live. I just find “timing” interesting. Let’s be clear. There are no long-term studies proving H. & Zpack OR Remdisivir is better for a patient’s survival. Maybe if hospitals are given this too to use widespread, the results will be different too. In the end, I hope I don’t ever become a guinea pig for anybody and always have a choice in my medical care, and I wish the same for you. Stay well.
If there is anyone I would trust, it is this channel. The many mindless fearful scream-rant comments here after the material is so excelently and calmly presented make me very, very sad.
Thank you for all the amazing videos explaining potential treatments. Do you think combining Omeprazole with Remdesivir can enhance effectiveness of Remdesivir. Alternatively, if the body cannot tolerate a 10 fold increase in Remdesivir, can the combination be used to reduce the dosage of Remdesivir (thereby increasing the supply)? Thanks!
https://blogs.sciencemag.org/pipeline/archives/2020/04/13/omeprazole-as-an-additive-for-coronavirus-therapy
“When controlling for age, sex, and comorbidity, Vitamin D status is strongly associated with COVID-19 mortality outcome of cases.” according to this study: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3585561
Those are some really bad results…
just awful. What is the point? I would say jog on and find something else to study
Always important to ask questions – at what stage was treatment started, dosage, length of treatment, what symptoms did the patient have. Neosporin is a great topical antibiotic but if you wait until your wound is infected and you have sepsis then it isn’t going to help.
Why does it seem that this is more about making money than saving lives?
@Rhyothemis princeps Love the idea of crowdfunded studies!!
@C_R_O_M__________ Much of the R&D for new drugs is funded by taxpayers through research grants and other support of university research labs. It’s the clinical trials that are funded by pharma, and they won’t run them on something promising like MCC950 if it is off-patent [1]. The solution is public funding for clinical trials. I would like to see some way to crowd fund trials. I’m not opposed to people making a good living for good ideas, but in the US pharma gouges since they can – you have to pay for life-saving meds – there is no choice, it is not a free market.
1 – “They state that while lapsed patent issues mean that MCC950 won’t itself
represent a commercially viable therapeutic candidate for treating PD … ”
https://www.genengnews.com/news/parkinsons-disease-drug-that-cools-brains-on-fire-could-enter-human-trials-in-2020/
BTW – NLRP3 inflammasome inhibitors might be useful for controlling inflammation in covid.
“Why does it seem that this is more about making money than saving lives?” Because it is. Big Pharma – and those who do their bidding – do not give a *blank* about people, only about dollars.
Stop the Philosophical Zombies are you against making money AND saving lives? Would it be better to NOT save lives and DON’T make money? How is Gilead or any Gilead out there going to fund their R&D, amortize their capital expenses, etc. Do you have in mind a better way to do it?
$800 a pill seems unattainable for most.
I really wish these studies would do a better job of distinguishing when treatment is started. For both remdesivir and HCQ+Zn, the proposed mechanism of action of the drug is to stop viral replication. Oseltamivir (Tamiflu) works the same way and must be given within 72h of symptom onset for it to be effective. Surely, this would be similar with other drugs that affect replication of other viruses. If you’re going to impact the clinical course, you’ve got to impair viral replication before it’s in every cell in the body. If they did what the VA tried to do and give it only to the sickest patients already in ARDS as a Hail Mary, they’re setting themselves up for failure. The drug’s not known or assumed to work on that physiology – though HCQ does have some immunesuppressant activity, it’s not been shown to be effective in this sort of scenario.
Doing a study doesn’t mean anything if it’s not designed around the right question.
@K MA Just because two anti-virals “sotp viral replication” does *not* mean they “work the same way”. There are, after all, many ways, even for a single virus, of stopping viral replication. And then for very different viruses, such as RNA viruses vs. DNA viruses, the mechanisms for stopping viral replication are quite different.
Let me guess, still on patent & VERY expensive? Money to be gained drives studies.
I guess you work for free.
Exactly. That’s why they won’t study HCQ and ivermectin that’s been safe and saving lives since before 1955 and 1981 respectively.
It will be fascinating to see where we are a year from now; to see what really did work and what didn’t.
It’s hard to know what worked or didn’t work with such a strange virus.
So one may soon be able to be prescribed Remdesivir IF one is sick enough (and lucky enough) to be admitted to a hospital that is able/willing to participate in the early trial. I have to ask, what will it take to get a medication approved for general prophylactic use in healthcare workers and others in at-risk occupations, or just those with early symptoms of cov19 that are not falling over in the street? Also of concern is the continued use of some PCR testing that can take days or a week to get results from, when patients can die at home in that timeframe.
Indian
judging only by the recovery time numbers the US study probably included earlier interventions. Without that data in the studies is imposible to judge… I suspect that like any antiviral early intervention is the key.
This ER doc advocates for early interventions: https://www.youtube.com/watch?v=wKHgDcbFTcM
So what’s your take? Is it better than hydroxychloroquine and zinc?
@Mike Wilson The financial incentive (or lack) is a problem, but remember: both the CDC and WHO said we need a *spectrum* of drugs for COVID-19. Just one is not enough. HCQ can be one of the spectrum.
@SpectatorAlius the problem, which is obvious to an Economist, is that there is no financial incentive to pay the expense of an HCQ trial as the drug is well out of patent. Therefore some philanthropist or government needs to step up. Best chance is the former, and you need one without too much invested in Gilead. The MSM scared governments from doing anything with HCQ.
It is much too early to say. An NTT of 28 is just not very impressive. No double-blind test has yet been done with HCQ+Zn and the various clinical/retrospective studies are inconclusive: some suggest it is very good, others do not. Dr. Seheult did a video on this about 4 days ago.
9pm it is then, greatings from Wales UK. Stay safe
I’m not a conspiracy theorist but I wouldn’t be surprised to discover that key people in NIH and US government own shares in Gilead. Remdesivir is a very expensive drug. Compare with the very inexpensive and much more effective hydroxychloroquine/zinc combo.
I have to agree. Plus some findings were released a few days ago which caused the stock to surge. I have heard that it is $1,000. Per injection, not a pill, and you must be hospitalized. If it is only for serious cases you would probably be in the hospital but if it is given to those with less severe symptoms that is a large additional axpense.
I own shares in Gilead.. if you have any kind of IRA or mutual fund, you most likely own shares.
@Irene B where was the news about that??? Don’t spread fake.news. I will report you.
Well.. gilead made announcement that they will give away remdesivir to the covid 19 patient. But they.are middle of fighting with Chinese scientists who developed remdesivir in China for patent for remdesivir. However, many believe gilead will win for patent for remdesivir.
onewomancircus it makes more sense to spread optimism for political reasons (since it is elections year as well) than what you suggested. Besides that whatever Gilead gets they deserve it. Gilead is the company that transformed HIV-AIDS to a chronic disease from a terminal disease, it also cured a certain type of hepatitis (which made them lose a lot of money because they actually CURED their customers – pharmaceutical companies don’t really like that, they want you on a permanent regimen to maintain cash flows high). Other companies aren’t that good.
Dr. Seheult, I’m not in the medical field or a master of statistics. Can you dumb down why they would stop the trial if it only hit half its objectives (shorten hospital stays)? To me it seems it helped people who would have recovered anyway faster but saving lives is still unknown. Great work btw.
They cut things short for ethical reasons–remember, they’ve divided their patient cohort into two groups–one getting remdesivir and the other getting placebo. These subjects are not “expendable” experimental lab animals, they are real, live human beings with a disease. So, if they see real potential for improvement due to the treatment, then they halt the trial early, so that the placebo group can be switched over to that treatment, hopefully before they get sicker or die. Of course, this limits the statistical power of the trial, but that’s a necessary compromise–bottom line is that in this kind of situation, human lives take priority over p values.
I don’t like the push for an expensive antiviral when there’s a possibility that a less expensive one can work. Just my two cents.
Remember tamiflu?
lipoic acid, silymarin, and selenium. natural cures?
Not very impressed with this study. Also what are the side effects? If you are dying you will try anything but that is not the reason they are approving this drug. I still would like to see HCQ given a fair trial, earlier in the disease, with Zinc and Z pack. That sounded the most promising by many, many doctors. Remdisivir sounds like a marriage of politics and big pharmaceutical with big dollar pay kits to get this drug approved.
Potential profit is driving studies, it’s criminal. Should be outcome, much cheaper biologics should be tried, vitamins, minerals etc.
Both studies were useless anyway and showed nothing as expected.
China is deliberately misdirecting everyone – 1. Their claim to have got the problem under control was nonsense. 2. The results of their study was deliberately wrong.
I wish the UK would move as fast as this as our death rate is horrendous.
Thanks for another great video!
May I ask for the link to that video of Biostatistics?
Patients are not little children. Leave the available options to the patients and don’t decide for them!
I am not convinced ny these 3.6% and would still go for hydroxy-chloroquine + zinc + acythromycine given the options. And if it becomes necessary heparin against thrombosis.
I am sorry that Gilead can’t make money with this treatment and that I can do it alone without hospitalization, but my own health as a patient would be the primary concern for me.
If you think I am putting my life in danger with this treatment, it is okay, because it is my life.
Respect our rights as human beings to decide over our lives. We are not serfs, and neither the FDA, nor the CDC nor the WHO are our masters. Our lives are our property, not theirs. We make the final decisions. They may give advice, but that’s all.
So just make all treatment options available in pharmacies and hospitals!
Patients are not medical experts. Let doctors handle this alright ?
Wonder why China’s test was not effective? There are also trials that show remdesiver did not help. I think they should push hydroxychloroquine with zithromycin and zinc in which has worked for many people. But they don’t want to because Trump pushed it.
Janice Smith It’s not profitable so it won’t be studied honestly.
“They” can’t stop the test. Too many patients, too many countries. Suppressing this data will not be possible. Can only delay and muffle it a bit.
Omg. 28 will take the treatment and 1 will live. Wow… we are really desperate… that’s around 3.5% success rate. No need to even upload this video for it. Sorry.
It’s not like 28 people take the drug, one lives and the other 27 all die. Thankfully the disease isn’t that lethal. It’s that if without the drug, out of a given number of patients, 28 would die, then with the drug, out of the same number of people, “only” 27 will die. That being said, yes, it is very underwhelming.
Well the purpose of this video is basically to show how full of bs media is and the biased push for remdesivir in the US.
One life saved out of 28 has nothing to do with Remdesivir, as there are hundreds of confounding factors that might have contributed to someone survival or death.
Boy I hated my biostatistics course. So boring. Probably would have enjoyed it if I had first taken probability.
Taking the parachute example, isn’t their test kind of like not allowing the parachute to open until they are x number of feet from impact? If x = 1 then nearly 100% fatalities. If x = 10,000 then nearly 0% fatalities. What is the value of x for 50% fatalities? How many fake parachutes (placebo) are required for it to be a statistically significant double blind study?
Since the percentage of people that have no to mild symptoms appears to be over 50%, shouldn’t we try to increase that percentage?
A study was done that showed a connection to vitamin D3 blood levels and severity of symptoms. Shouldn’t everyone either get enough sun and/or take a vitamin D3 supplement?
Has there been studies of vitamin C blood levels? Some doctors say they are having success with intravenous vitamin C.
How about blood levels of zinc? or NO (which is derived from L-arginine)? or Copper? etc.
Nutritional deficiencies are common. Drug deficiencies are not common. How do these common nutritional deficiencies affect our ability to resist covid infections?
I am about to do a multi … vitamin? Suppliment on ebay. C, D3, Quercetin and Zinc Sulfate and a little Zinc Gluconate. I already have one without the D3 available and one without the C available
@Michael W. Perry Aerobic exercise. Particularly if the endothelial inflammatory activation/thrombotic connection proves to be the major pathpohysiological mechanism. Exercise is one of the best preventative strategies against that.
Sean Bearly
We need to build more tinfoil hats
Let’s not talk about fake parachutes please! lol
There are reasons that certain information either isn’t being sought after or isn’t being reported. It could be that more studies and information would show the reaction to this virus has been overblown, or that it might make people less fearful and thus less willing to accept quarantine, loss of jobs, etc. If the money being thrown into creating a vaccine was instead put into developing cheap, easy to use test kits for checking for the anti-bodies and a massive testing regime put in place we would at least know how serious this situation is. And the testing would need to take multiple data points about each person tested, like race, health issues, age, some lifestyle questions (like how much outdoor activity, exercise, diet). Crazy that hasn’t been done.
Good news on Remdesivir.
But I’m concerned on the virtual absence of HQN and zinc clinical trials. It’s almost suspicious how absent this combination is as a potential therapeutic.
Hydroxychloroquine does not generate royalties and the major manufacturer is India, they don’t want India to have such leverage. The same goes for Favipiravir, a promising drug but from a Japanese lab but Japan does not have enough cases to test the drug themselves. Once again economic interest over health. Remdesevir is from Gilead, an American company, of course, they want it to be the cure, imagine the revenue it will bring to USA.
The drug improved the mortality rate by 3.6% but that is an improvement on the outcome by 31%. Remember that an absolutely perfect cure would only improve the mortality rate by 11.6%, became the rest survive anyway. So remdesivir is 31% effective compared to a perfect cure. Given that we don’t know of any other cures, this is a big deal.
Mohamed Belhadj
It is not the same I can tell you that. When you assume a patient will die due to COVID-19, doctor will tell the patient that if u take Remdesivir, you will have 31% decrease risk of mortality. But that is often misleading, becoz you don’t know that! Patient might be helped, harmed or unaffected by the drug. That is why we often need to calculate NNT. Especially if we start giving the drug much more early when patient is not that severe
There are many people who stand to make millions of dollars if Remdesivir is effective against Covid. On the other hand, HCQ (plus zinc) is generic and no one stands to make millions if it is effective. So given the reliability and ethical standards of the people running these tests, it is highly unlikely that unbiased results will ever be attained.
As search engines get polluted with nonsense a lot, it is a bit unclear what the current situation is. First impressions were that it was ineffective at best and probably dangerous as in the small and somewhat haphazard studies, patients with HCQ died twice as often. 22% vs 12% if I recall correctly. The original French study has been retracted for being too flawed to find meaningful information. Several studies are still underway and it may be useful for the suppression of the virus in early stages, but so are masks, that will make you look silly, but won’t kill you. No conspiracy here. The amount of attention Gilead’s product gets from the US, is also a bit suspect from a scientific point of view. Dr. Fauci seems to be convinced though. The question is however if the production of Remdesivir can actually be scaled up to the billions needed if the studies are successful. It is too early to tell really.
At least you’ll find some leads into the topic if you want to find out.
https://en.wikipedia.org/wiki/Hydroxychloroquine
Let’s all hold our breath until a study comparing Remdesivir, hydroxychloroquine, and a control group is done. Or maybe let’s just go on a fast or something.
HCQ is getting smeared in the press as if it didn’t have 7 decades of “safe and effective” use going for it. After seventy years of consistent use it has become “risky”. Funny. Not funny “haha”.
Why are you listening to the media, who know zip about science and who frequently misunderstand or don’t know the meaning of “maybe” ,”possible treatment”, “perhaps” , “promising”, “probable” . Researchers will give you numerical answer with statistics.
@Cici Bradley No, it is not hogwash. When HCQ is used for its FDA approved indications, the risk of QT prolongation is low. But COVID-19 affects the heart, too. So it is *quite* possible that the risk of QT prolongation is higher. So they are doing the right thing by doing an ECG first.
@Cici Bradley The marketing formula is simple, tried, and true. Use the credibility of the FDA, NIH, mainstream journalists and others–the pharmaceutical-industrial complex–to instill fear of a treatment so people won’t demand that treatment. Then put up a new and exxxpensive drug and see to it that the reporters do their part to trumpet its merit. Then dump tons of money into the coffers of the Complex’s managers. They really don’t care about… Well, you see where I’m going.
Pitchforks and torches.
Lawrence Tanner Well said. HCQ has been saving lives since before it was FDA approved in 1955. Now all of a sudden you have to get an ECG before taking it? Hog wash. Furthermore, I’ve taken it twice a day for almost 21 years, right at 15,000 pills I reckon, without hitch.
Remdesivir – Patented = expen$ive = profits. HCQ – generic = inexpensive. Profit *only* in high volumes… Do you see where this is going? That’s why the “push” by Gillead… Gillead isn’t even geared up for high production and it’s having troubles now in low quantities… Letting people die for a “study” for a chance at profit is unethical in my book. Though I know studies do need done. But not on high risk people who could die.. Use what works and is more readily available.
NIH knew about HCq in-vitro studies done in 2006!
china’s numbers are fake news lets be real
What about HCQ+AZ+Zn?
There is comparatively very little money that can be made from that so it will be shot down, regardless of how effective it actually is. Big pharma = big tobacco.
After watching all of your videos on this subject, since the beginning of this pandemic, I find it difficult to listen to people whose soul source of information is CNN.
Or Cctv lol.
@Good Man ew. Please don’t recommend propaganda..
@Good Man : fox noise.
Then listen to Foxnews or TBN 😃
So the studies are based on patients presenting to hospital within first 12 days of acquiring symptoms. Not clear what % had (a) mild symptoms or instead had (b) more serious symptoms. If it is possible to distinguish betweens mild/moderate -v- severe symptoms then perhaps the analysis should have been broken down into those 2 streams (within both the remdesivir & placebo groups), because the mild category have less chance of ending in mortality ?
Thank you so much.💖💖💖
I feel like its already shown that it attacks 2 areas, confusing us. I bet there is a 3rd thing that happens after it infects vascular system. Like, we cant put all our eggs in this basket like we did with ventilators
We already know it can infect the nervous system too – there are reports of people losing the ability to speak (without having a stroke) or developing other kinds of rapid-onset dementia. Might explain the loss of smell too – direct damage to the olfactory nerve.
Could the number of people needed to be treated been lower had the study been allowed to continue?
Also im no doctor, so what does the number 28 mean to you? Is it too high for this to be considered a powerful treatment? Or is it significant enough? Obviously ik ideally you want to get to 1. But what is a reasonable threshold?
@presde34 It makes perfect sense. If a disease “only” kills one in 9 people, then yes, the best you can do is to save 1 life out of every 9 because the other 8 would have recovered on their own anyway.
@Michael W. Perry the other thing I am wondering is if there is an error in the calclution? Based off the study, If the disease already has a 11% mortality rate without remdesivir and 8% with. Then wouldnt the percent decrease in mortality be 27% and not 3%?
11-8 is 3. 3/11 is 27%.
So if did 1/.27 we get approximately 4 people which is a significant difference from 28.
Again Idk which method right, but if the method in the video is correct then the highest possible decrease is 11% and 1/.11 is about 9. That does not make sense to me.
Number 28 means that Remdesivir is useless for COVID-19 and one life saved out of 28 has nothing to do with Remdesivir, as there are hundreds of confounding factors that might have contributed to someone surival or death.
One in twenty-eight is about 4%. If you had an often-fatal disease, how delighted would you be if your doctor offered a drug that he said would reduce your chance of dying by 4%. I suspect not much. Add into that another factor. There are other drugs that some researchers are claiming offer far better results than that. If they’re right, this drug is little more than a distraction, pursued only because it is new and likely to be expensive.
Donald Rumsfeld strikes again and gets a big contract for his company. i personally, would not trust any american study
They had no balls to run Remdesevir against Vitamin C or Vitamin D ….
i bet each one of the Vitamins alone would have an better outcome than remdesevir.
@Mello.B33 Troooll! Troll in the dungeon!
Zinc Vitamin D & C should be in the diet for 100 effectiveness!
Just feed people with better and nutrient dense foods and COVID-19 becomes harmless.
and zinc
Comunist! How are the poor pharma industry going to survive? Just on opioids?
Well presented for people with medical knowledge as well as for those with no medical knowledge! Thanks 😀
Zilgma Irbe And your lovely for yours ❤️
You’re lovely for your comment
Follow up on Ivermectin.
Medcram is best You Tube based platform to follow, very detailed videos and everything is explained in very simple way, thank you doctor for all the work done regarding Covid 19.
only if he stops with the China facts. China must pay!!
My go to source for reliable information
Das ist falsch und Unsinn!
Now the question is will they give Remdesivir early on during the course of the disease to prevent severe lung damage and cardiovascular damage? Or will they wait until they patient is very ill and will probably have lifelong health problems from the advanced lung and cardiovascular damage?
If it was same as chinese protocol then cohort was hospitalized paciets 12 days into symptoms.
*insurance companies furiously run cost benefit analysis*
I have earlier told, no old medicine will be allowed to be successful
@Mello.B33 That is a dangerous falsehood. Lots of people who “eat nutrient dense foods” are still dying of COVID-19.
Eat nutrient dense foods and there is no need to worry about COVID-19.
skydivers have more than one parachute in case the first one fails. i can’t believe it’s taken this long to find only one effective treatment for covid19. imagine if ebola had the r0 of covid19, kind of a scary thought
Have a look at how lethal certain strains of bird flu (like H5N1 or H7N9) are when they occasionally infect humans. If one of those viruses ever evolves human-to-human transmission it may seriously end civilization.
Yeah, I have the feeling that this pandemic, even if it’s the worst in 100 years, could be just target practice compared to what might come. I hope I’ll be long dead and buried before something like airborne Ebola or MEV-1 from the movie Contagion make an appearance.
Next study: parachute vs placebo.
@TJ Media Russia roulette!
placebo is a backpack full of sand lol
I think a double blind randomised test will be required to establish the effectiveness of parachutes.
Or how about parachute vs. bale of hay? During WWII, Soviets facing a shortage of parachutes stuffed soldiers in bales of hay and dumped the bales instead! I even remember a physics homework problem estimating how high up they could drop them from without breaking bones.
🤣 EPIC
Question: Why did the trial in China land so differently? Seems like we’ve seen several cases where China says “doesn’t work” and other areas of the world find it does. Not sure how to interpret that.
I agree with @rla1000. Small of patients AND patients were being enrolled in the study pretty late in the progression of the SARS-CoV-2 virus, so the impact of Remdesivir would be less noticeable or, not statistically significant.
just look how hard remdesevir is pushed under all possible treatments, they just made study after study on remdesivir until they had one study with an positive outcome. Also remember the last study where recovery time was pro remdesivir and mortality rate was not signicant lower. If you had stopped that study earlier, the mortality rate with remdesivir would have been lower with remdesivir aswell.
To me it looks like they designed this study in that way with that high number of patients to alow them to stop the study at the point where remdesivir has a small window of being better than no treatment.
@American Girl they did that with Ketimine a 30 cent drug into a 3000 dollar
drug.
The adult response is that there’s too many factors and too small a sample size to say with absolute confidence whether a prospective drug is the CAUSE of patient outcome betterment. Even the study by the NIH might also have hidden biases in the selection of the people who received treatment.
Because Remdesivir is useless against COVID-19 thats why.
Dr. Seheult, thank you for your always informative videos, I’ve been staying tuned since medical school;) In regards to this video, is there enough evidence for you to treat patients? Also, how do you use studies out of China as we know the CCPs penchant for misinformation, I would put a lot more weight into a study out of the US. Do you trust the case numbers coming out of China?
Double-blind studies cannot be manipulated.
@Irene B Yes, someone treated Hepatitis C with dietary supplements… why dont you just go and treat covid 19 patients with essential oils while you are at it
remdesivir patent was purchase from Gilead by China…how about lipoic acid, silymarin, and selenium. It was used to treat Hep C
Scientific studies (Chinese or not) can give misleading results for all kinds of reasons (conflict of interest/overlooking something/not enough data). The study from China actually ended with the inconclusive results — and they said it themselves.
Therefore, the ANY scientific question is often the subject of study for several times in various forms before the results are applied for practical purposes.
That said, Chinese government does not have the best interests in heart for other countries and not even for the Chinese people. But, I think, it is not the case that any study from China is automatically garbage.
Furthermore, I am about just as sceptical of the USA study. The drug structure looks very difficult to manufacture, and only Gilead makes it — huge profits.
May be true ! Western countries hyped The Covid19 Vs Influenza Death (Compare info on CDC)!
See you at 3pm from here in Chicago.
I sincerely appreciate your perfection.
Please take a look at Leronlimab. It looks really promising.
It went under the radar for so long. I don’t know why.
Thanks but no thanks. I will request the hydrochloroaquine & Azithromycin wth zinc. Fauci is deep state & this Remdisiver is still under patent & very expensive & is inferior to the other HCQ.
@Zilgma Irbe Well these are 2 compelling, properly designed studies stating remdesivir doesn’t work. A Number To Treat of 28 is too high to be called effective.
Anyone who does not back their claim of “cures working” with a link to at least one conclusive study, is talking out of their backside. And I personally haven’t seen any conclusive studies yet
Many countries with competing interests are testing all kinds of drugs, and, besides, no one can fudge results for long if there is this urgent interest
Still waiting for a a proper Zinc+Hydroxychloroquine study. :-/
@S W or you could just buy quinine tincture
@Keith You may want to include grapefruit, it contains some quinine in the fruit and peals. Many boil grapefruit halves with the peals on to extract the quinine and drink it as a tonic water. They usually include other benefitial fruits and herbs when they make it and sweeten with raw honey.
From what I’ve seen (Dr. Seheult’s videos), looks like asymptomatic and mild case folks should be taking HCQ (or Quercetin), zinc or what Dr. Seheult takes at home. If folks have more serious cases, then once in the hospital, remdesivir or other drugs should be prescribed. Seems like there’s a time factor involved going from mild to serious what therapeutics will work. There’s no one cure all currently until we get a vaccine. Agree that all these studies need to play out with valid results not quick trials that the media runs with.
@no name Other studies I have seen show amounts of vitamin D and how those with higher levels have lower severity of symptoms. Those with low vitamin D had more severe symptoms. This also explains why Hispanics like myself and African Americans were dying more from the disease. Its harder for darker skin colors to produce vitamin D. So I take vitamin D, zinc, and eat oranges.
in yesterdays video he showed how important zinc was… its just for money, a generic cheap drug wont make any money, china looking for new patent on improved remdesivir also, so lets borrow trillions to buy some chinese patented drugs to fight the china virus. lol such a scam
Nice presentation Doc ……
Thanks for the lectures…esp ur POCUS lectures….im big fan of it, it motivated me to learn more abt the topic…
Doesn’t seem that effective.
It’s early days yet. You are seeing research live, normally you see the end result only. Research is reiterative and normally done more or less sequentially. Because of the situation, every avenue is being explored simultaneously all over the world thus the wide variation. Every little bit of knowledge is helpful, that’s why these papers are being released so quickly.
the US has crossed 60,000 deaths. if 1 in 28 of those hadn’t occurred, that’s over 2,000 lives saved. think about the scale we’re dealing with. world wide, we’ve crossed 200,000 deaths which means over 7,000 might’ve been saved assuming 1 in 28. it’s not amazing but like Dr Fauci said on Wednesday when he talked about the study, it’s like when there was nothing at all against HIV and they discovered AZT had some positive effect as a treatment.
IIRC, this drug was developed to use against Ebola but they discovered monoclonal antibodies did a better job.
@Earl Hickey Good question! I am very suspicious of their decision to simply not count those who had to drop out due to side effects.
@C_R_O_M__________ at least not effective enough to bet on that horse. what about the people dropped out of the study due to sideeffects ?
1 out of 28 may not seem that much but it is much better than 0 out of 28 which would be closer to the placebo value.
Thank you for clarifying the significant studies of Remdesivir efficacy to date.
@C_R_O_M__________ statistical significance DOES NOT mean clinical significance or any meaningful result in the real world.
@Claudius Drusus yeah, it seems those destined to die from covid will die from it, remdesivir or not(8 vs. 11.6% is nothing). and those who recover will recover a bit faster with it.
@C_R_O_M__________ in terms of recovery. But not in mortality. A confusing outcome. Would be Kool if we could see the data.
Mello.B33 there was pretty solid statistical significance in the second study.
You mean no efficacy of Remdesivir against COVID-19 ? Both studies showed nothing.
Using your formula for determining lives saved if remdesivir is used as a treatment, more than 2,000 deaths would have been saved in the US, out of the more than 60,000 deaths experienced as of today. That looks significant to me.
Kathy Sharpe, you need to go back to school!
Kathy Sharp Please check your calculator. Your numbers are off.
And it also costs about 2,000 times more
@joeconsumer could you please elaborate? Are you saying that if someone died in the remdesivir group that docs would then classify the patient as “poor candidate” and remove them from the sample?
The main difference between the Chinese study and American study in determining outcome was the source of STUDY FUNDING. The American study could have easily used FDA rules to eliminate 1 in 15 study fatalities as “poor candidates”, tipping the balance in favor of the self-funding drug company.
I wish there was a similar study using hydroxychlorine (sp?) and zinc. I believe it’s a much cheaper drug. Using it early (if you are already seriously ill then it’s probably too late) in the infection could save lives, right? The US should pour millions of dollars into a study using this drug.
Look at my post on here.
There is no profit incentive to give it a fair trial with zinc and administered early. All HCQ studies thus far have sabotaged any chance if a favorable result and I believe it’s by design.
It helps but it is not effective to control the pandemia by itself.
@Zilgma Irbe learn some statistics please and then comment.
Any port in storm.
@Mello.B33 Troooll! Troll in the dungeon! *faint*
It doesn’t help at all, there is no scientific evidence showing the opposite.
This is an honest question. Are we actually believing China’s data and so forth. I’ve seen and heard plenty that suggests maybe China isn’t a reliable player.
Scientific studies (Chinese or not) can give misleading results for all kinds of reasons (conflict of interest/overlooking something/not enough data). The study from China actually ended with the inconclusive results — and they said it themselves.
Therefore, the ANY scientific question is often the subject of study for several times in various forms before the results are applied for practical purposes.
That said, Chinese government does not have the best interests in heart for other countries and not even for the Chinese people. But, I think, it is not the case that any study from China is automatically garbage.
Furthermore, I am about just as sceptical of the USA study. The drug structure looks very difficult to manufacture, and only Gilead makes it — huge profits.
Surely you don’t trust US numbers/studies either, right?
the counter question however is – speaking about that US study, can you truly believe that also? given that the drug is patented, and only one company is producing it, and the article I’m reading is saying they can only make enough to treat 500k people till October, and we have over 3mil infected worldwide right now!
if it really was that good for this, I’d like to see a lower mortality in the group treated by it, but is was only 8% vs 11.6%, I’m simply not convinced that this is the right thing, it sounds much more like a way to siphon a lot of social security money into patent owners bank account
China lied people died.
Stop watching Fox News?
If they would need to treat 28 people to save only one, it basically means that Remdesivir is 100% useless for COVID-19.
@Kathy Sharp you are obviously science illiterate, you can’t control for
confounding factors (in the complete absense of data), no matter what math and statistical analysis you use. Most medical trials are poorly designed, poorly controled, and poorly conducted and this is why many of them are nothing more but a pseudoscience. And this is exactly why many of them contradict each other etc. And this is exactly why pharma can run 10 trails on the same drug and publish only one that shows miniscule benefit (statistically significant) and burry the other 9 ones and introduce the drug to the market anyway. This is also why statistics based on flawed, incomplete and inaccurate data will not show you what actually happens in the real world.
People like you are clueless beyond belief. You have no idea how much mess (bias, fraud, personal interests etc.) is there in science and medical fields in general.
Not 100% useless. Only 96.43% useless…
@Mello.B33 > There are many other confounding factors
…which are ACCOUNTED FOR IN THE TRIALS of any medicine, this one included. This is not the first time humanity runs medical trials, for EFF sake! We have 100+ years of experience how to control for other factors.
More like you are 100% math illiterate.
Curious about your thoughts on combining sofosbuvir and daclatasvir Hepatitis C drugs which are being trialed for Covid-19 treatment. Thank you!
@Zilgma Irbe I did it last year with Epclusa , $84,000 was the cost. One pill is ~ $1,000.
If I am not mistaken, this drug combination for the hepatitis C treatment costs about 3 000 USD in India and 65 000 USD in Europe and god knows how much in USA?
Hello all, greetings from Juarez, Mexico
A big Hello from TEXAS!!😀🦋🌻🕊🙏🎯
@Katie Kane hello from NW Ga.
Hello from N. Georgia, USA!
Saludos de Tijuana
Cuanto me alegra que otros vean esta información
Greetings
Probably could have given these patients high dose intravenous vitamin c and gotten better results……
Could you discuss whether fasting and/or a whole food plant based diet could effectively lower oxidative stress. Also, could you talk about a whole food, plant based diet and its positive effects on cardiovascular disease and hypertension and diabetes which are all comorbitities for a more serious disease outcome with Covid 19.
Remdesivir scam. Dont work .you still sick and doent kill virus $1000. Pill. Hydroxychloroquine. 69cents . Wake up .
Thanks for confirming this is indeed good news!
How is it good news ?! It shows on effectiveness, none whatsoever. One life saved out of 28 has nothing to do with Remdesivir, as there are hundreds of confounding factors that might have contributed to someone surival or death.
I don’t trust anything coming from China…
@Andi Gjata
Not really, lol.
the device you are using right now comes from china, you trust that?
Why bother with this when the Chloroquine works faster and it’s $1 instead of $1,000?
Anyone who does not back their claim of “cures working” with a link to at least one conclusive study, is talking out of their backside. And I personally haven’t seen any conclusive studies yet
Possibly can’t be used on older or sicker patients.
@C Baker Which study is this?
Chloroquine is still used in many hospitals, but isn’t any better than placebo
because choroquine DOESN’T work according to randomized placebo-controlled trials.
This is encouraging!
Statistical significance DOES NOT MEAN clinical significance aka meaning of validity in the real world.
yes china shall make many millions off their new patent of an improved remdesivir, your grandkids will foot the bill as we borrow borrow borrow trillions.
Hello from Greece 🇬🇷
Sofia i think he likes you….😉
@MedCram – Medical Lectures Explained CLEARLY Hello from Hungary, Eastern Europe – thank you so much for your work. Stay safe
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Can we rely on data from China?
Not sure if that is wise…
I volunteered for Rendesivir trial.
@Jeffrey Leung is that why China sends it’s brightest student s to Europe and America to learn Science…or steal it?
Maybe both.
They have a very poor track record of Science and Physics only until America and former Soviet Union educated them.
My University is 50% China
Elaniago, what’s the other side of the coin? If you mean China’s side of the coin, then I’m curious, how do you justify China’s actions? (if you mean something else clearly define it).
Man we cannot trust China, but we can’t trust the FDA, Wall street, Gilead and Big pharma either so… 🤷♂️
DefineMeAsOne
You need to look at both sides of a coin or you are just saying nonsense.
Thank you for visiting us at https://www.MedCram.com
At our website, browse all of our videos and CLEAR explanations of over 60 medical topics. We also offer CME/CEUs for medical professionals, medical programs, and institutions.
All links referenced in this video are in the video description. Quick links to our previous updates on the coronavirus pandemic:
– Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress: https://youtu.be/22Bn8jsGI54
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://youtu.be/fn2yk5SbGiw
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC): https://youtu.be/NM2A2xNLWR4
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion): https://youtu.be/nO4xgcIaPeA
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
– Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
– Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing? https://youtu.be/kgzFAdYwYLM
– Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse? https://youtu.be/o8aG63yigjA
– Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: https://youtu.be/qc6VV7ue4cE
– Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: https://youtu.be/E7MufS6dnJw
– Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: https://youtu.be/fya6Zwxch88
– Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): https://youtu.be/uaIzj3s3p4A
– Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: https://youtu.be/JN-8bGB1cLM
– Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu: https://youtu.be/H1LHgyfPPQ8
– Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine: https://youtu.be/EFRwnhfWXxo
– Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention: https://youtu.be/G1zsE9_85i4
– Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful? https://youtu.be/A4eu-h_owaI
– Coronavirus Pandemic Update 43: Shortages, Immunity, & Can a TB Vaccine (BCG) Help Prevent COVID-19? https://youtu.be/LqKwAIIy-Mo
– Coronavirus Pandemic Update 42: Immunity to COVID-19 and is Reinfection Possible? https://youtu.be/q4P91VrfPGw
– Coronavirus Pandemic Update 41: Shelter In Place, FDA Investigates Hydroxychloroquine for COVID-19: https://youtu.be/hPz5KxgI_K4
– Coronavirus Pandemic Update 40: Ibuprofen and COVID-19 (are NSAIDs safe?), trials of HIV medications: https://youtu.be/dT6mHi_8V5E
– Coronavirus Pandemic Update 39: Rapid COVID-19 Spread with Mild or No Symptoms, More on Treatment: https://youtu.be/AToF8O5T86s
– Coronavirus Pandemic Update 38: How Hospitals & Clinics Can Prepare for COVID-19, Global Cases Surge: https://youtu.be/MoisrCTu0SY
– Coronavirus Pandemic Update 37: The ACE-2 Receptor – The Doorway to COVID-19 (ACE Inhibitors & ARBs): https://youtu.be/1vZDVbqRhyM
– Coronavirus Pandemic Update 36: Flatten The COVID-19 Curve, Social Distancing, Hospital Capacities: https://youtu.be/vww1nIIoqmw
– Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments: https://youtu.be/vE4_LsftNKM
– Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown: https://youtu.be/U7F1cnWup9M
– Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: https://youtu.be/Mm7UrZeu-74
– Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? https://youtu.be/Eeh054-Hx1U
– Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? https://youtu.be/7YI2tOoVVpk
– Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention: https://youtu.be/gmqgGwT6bw0
– Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran: https://youtu.be/XjEacUyp4vY
– Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate: https://youtu.be/quDYb_x54DM
– Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases: https://youtu.be/xQwfuJgJ9lo
– Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic? https://youtu.be/bV1CZxJ-uvU
– Coronavirus Epidemic Update 25: Vaccine Developments, Italy’s Response, and Mortality Rate Trends: https://youtu.be/UImSVhLLeGY
– Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms: https://youtu.be/wFoj2L2LpNA
– Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats: https://youtu.be/JGhwAGiAnJo
– Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing: https://youtu.be/OqpHvK0XADY
– Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?: https://youtu.be/9BYaywITXYk
– Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins: https://youtu.be/Ka48UZDDzLY
– Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials: https://youtu.be/4HK9QEy1KJ8
– Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips: https://youtu.be/vE4pBkslqS4
– Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19): https://youtu.be/wlbM6VVkVZM
– Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19): https://youtu.be/qqZYEgREuZ8
– Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19): https://youtu.be/o804wu5h_ms
– Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks: https://youtu.be/pDnmHu8x9C4
– Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada: https://youtu.be/0UgrPgJdzp0
– Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV: https://youtu.be/GT3_A1bf9pU
– Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine): https://youtu.be/pfGpdFNHoqQ
– Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV): https://youtu.be/gPwfiQgGsFo
– Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate: https://youtu.be/8Hjy3UfaTSc
– Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA: https://youtu.be/GpbUoLvpdCo
– Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding: https://youtu.be/nW3xqcGidpQ
– Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period: https://youtu.be/UGxgNebx1pg
– Coronavirus Update 5: Mortality Rate vs SARS / Influenza: https://youtu.be/MN9-UXsvPBY
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
– Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine: https://youtu.be/SJBYwUtB83o
– Coronavirus Symptoms, Diagnosis, Treatment: https://youtu.be/UCG3xqtcL3c
– Coronavirus Outbreak – Transmission & Updates: https://youtu.be/9vMXSkKLg2I
MedCram – Medical Lectures Explained CLEARLY
Here it is: https://youtu.be/SwtTxgxYPEk
You always make things so easy to understand. Thanks once again for a job well done.
I am waiting at the webinar. Sorry you guys are having difficulties, what about live streaming on youtube?
@no name genetic fallacy brainlet. Lots of data from China has been verified as true. Such as rates of severe cases and time spent on ventilators.
MedCram – Medical Lectures Explained CLEARLY Thanks for all the information Doc!
Thank u doc 👍