COVID-19 Update 65 with critical care specialist and pulmonologist Roger Seheult, MD of https://www.medcram.com
Dr. Seheult breaks down multiple studies that illustrate how oxidative stress (primarily from reactive oxygen species) and endovascular inflammation may play a key role in COVID-19 infection severity. The understanding of this pathway may give important guidance for the prevention and treatment of severe coronavirus infections.
Links referenced in this video:
COVID-19 Clinical Updates & Lessons Learned So Far with Dr. Seheult – Live Webcast Replay https://youtu.be/LWsgbgz5euc
Johns Hopkins – https://coronavirus.jhu.edu/map.html
AWR – https://awr.org/health
Journal of Thrombosis and Haemostasis – https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1538-7836.2004.01085.x
NIH – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936474/pdf/nihms548534.pdf
APJAI – http://apjai-journal.org/wp-content/uploads/2020/03/1.pdf
American Journal of Physiology – https://www.ncbi.nlm.nih.gov/pubmed/18660448
Inflammation Research – https://www.ncbi.nlm.nih.gov/pubmed/25721616
Pathophysiology of Haemostasis and Thrombosis – https://www.ncbi.nlm.nih.gov/pubmed/25721616
Karger – https://www.karger.com/Article/Abstract/73600
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology – https://www.ncbi.nlm.nih.gov/pubmed/31577152
Hindawi – http://downloads.hindawi.com/journals/omcl/2018/9719584.pdf
Frontiers – https://www.frontiersin.org/articles/10.3389/fcimb.2017.00373/full
Some previous videos from this series (visit MedCram.com for the full series):
-Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update https://youtu.be/Z2hfGcTokiY
-Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress https://youtu.be/22Bn8jsGI54
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://youtu.be/fn2yk5SbGiw
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) https://youtu.be/NM2A2xNLWR4
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion) https://youtu.be/nO4xgcIaPeA
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
– Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
– Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?: https://youtu.be/kgzFAdYwYLM
– Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?: https://youtu.be/o8aG63yigjA
– Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: https://youtu.be/qc6VV7ue4cE
– Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: https://youtu.be/E7MufS6dnJw
– Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: https://youtu.be/fya6Zwxch88
– Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): https://youtu.be/uaIzj3s3p4A
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
Many other videos on COVID-19 (coronavirus outbreak, coronavirus symptoms, influenza, coronavirus epidemic, corona virus updates, coronavirus vaccine, boosting the immune system, vitamin D, vitamin C, Zinc, Quercetin, NAC, n-acetyl cysteine, Insomnia, PPE, hydroxychloroquine, ultrasound to diagnose COVID-19, coronavirus New York, COVID-19 and the epithelium/blood vessels) and other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com
Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at [email protected] if you are interested)
Media Contact: [email protected]
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MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus
Add this paper to list that shows quercetin possible mechanism of action
https://www.ncbi.nlm.nih.gov/pubmed/27160136
Marseille : Didier Raoult acclamé par des chauffeurs de taxis https://www.youtube.com/watch?v=E_yA-Ac4-aM
Dr, seheult, you are a genius. your approach towards explaining things is really amazing.
Wake me up when we have a treatment.
Very exciting info. Encourages a healthy life style.
Dang, another cliff hanger! Can’t wait till next week for another epic learning session.
Would coenzymeQ10 possibly reduce oxidative stress in people who contact Covid19? I think so.
i enjoy watching and learning much better than when i was in med school visual illustration we understand better and information retention is better also. Thank you Dr Seheult…
I wish he’d cover the Randle Cycle; https://en.m.wikipedia.org/wiki/Randle_cycle
Also, I need to redo my understanding of glycolysis. I thought the Electron Transport Chain was one of 3 pathways to producing Adenosine TriPhosphate.
Everyone talks about the Krebs Cycle (AKA Citrate Cycle) when ETC makes more ATP (and NADH) – Is there a good vid on that…?
Say we were able to somehow temporarily increase the concentration of ACE2 and An(1-7) and the other things in the body, won’t the virus eventually catch up? Is the point of all this to buy patients more time to fight off the disease naturally?
What about treatment like convalescent plasma tranfusion thru covid19 survivor? How does the mechanism work?
Hi! I’d very much like to see C-reactive levels on SARSCoV2 patients, as a factor to consider on clinical diagnosis.
another great video – although i will admit this one was much more science heavy than i can handle
Sorry doc, it’s whole grains and sugars that cause you to get fat. Eat meat, vegetables, fruits and good fats to get healthy.
So, stop smoking, drinking, no sugar, and eat your vegetables, right? Isn’t that what your mother told you when you were a kid!
People with acute COVID 19 don’t have a high blood pressure when hospitalised. The are treated for high blood pressure before the are hospitalized. That’s again a huge difference.
And when then those acute covid19 people die, is not from high blood pressure but from excess low blood pressure. And treatment with nor- adrenaline that doesn’t do anything for blood pressure when receptors of ACE enzym are occupied due to induced toxicity of ACEI’S.
Nice review of the literature. Since you’re listing enzyme mineral dependencies, you might want to include selenium for GSHPX, particularly since Se deficiencies are common.
I’m seeing a role for NAD precursors such as NMN ( Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside)
This is like watching the birth of new medical insights live.
The most remarkable finding was the surface expression of ACE2 protein on lung alveolar epithelial cells and enterocytes of the small intestine. Furthermore, ACE2 was present in arterial and venous endothelial cells and arterial smooth muscle cells in all organs studied.
reference Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.
Hamming I1, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H.
Author information
Department of Pathology and Laboratory Medicine, University Hospital Groningen, The Netherlands. https://www.ncbi.nlm.nih.gov/pubmed/15141377
Thanks again for the clear explanations. Since Nitric Oxide plays a role in reducing oxidative stress, would increasing NO, through exercise, supplements and foods high in NO, help alleviate oxidative stress? I am looking forward to further updates.
Great to see flavonoids help with oxidative stress. So even if Quercetin turns out to do nothing against the virus as a Zn-ionophore, at least it can help to reduce oxidative stress.
treat with recombinant ACE2 or angiotensin1,7 ? How about folks with DD (homozygous deletion polymorphism) in ACE? They tend to have higher circulating levels of angiotensin II…. Once saw linked to hla-b27 uveitis, cytokines
When do you sleep? I am overwhelmed with the level of knowledge and research that goes into making these daily videos. Udaman!!
This paper, out of Wuhan Institute of Virology describes the experiment, combining the SARS-COV and HIV viruses.
In this study, we investigated the receptor usage of the SL-CoV S by combining a human immunodeficiency virus-based pseudovirus system with cell lines expressing the ACE2 molecules of human, civet, or horseshoe bat. In addition to full-length S of SL-CoV and SARS-CoV, a series of S chimeras was constructed by inserting different sequences of the SARS-CoV S into the SL-CoV S backbone.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258702/
Was Luc Montagnier, Nobel prize winning geneticist, right all along?
https://www.latintimes.com/covid-19-result-hiv-vaccine-attempt-gone-wrong-china-claims-french-nobel-laureate-luc-457948
Relative risk of admission with C19 in NYC : diabetes 3.2 (not shown in video); HTN 2.2; obesity 1.5; being male 1.25; COPD and asthma 1.0 (Richardson et al)
RR of mortality from C19 in NYC for over 60s: males 1.36
It appears there are over two dozen studies still underway combining Hydroxychloroquine with azithromycin giving a dangerous compounded QT risk rather than doxycycline, which you noted might have some benefit in a different way?
Any further thoughts on benefits of Quercetin in place of hydroxychloroquine Plus zinc for early treatment or prophylaxis?
Not all asthmatics are equal. I have sever asthma and when I lived on the east coast I would have 20+ attacks a day. I ended up moved to the desert thinking without allergies I wouldn’t have asthma. Even in winter I still had attacks. My physician found that my asthma was due to the lack of NO in my airways. Nitric oxide is endogenously released in the airways by nitric oxide synthase and I found I barely make it which causes my asthma. Their are test strips to see how much you have for the mouth since NO dissolves in the mucus. I wonder if the asthmatics with COVID-19 issues have this form of asthma? BWT doing things to boost my NO has helped.
How?
While conventional doctors don’t like to talk about vitamins beyond D and a mult based on 1987 RDA recommendations, you have been willing to advise your immunity building techniques Way back in number 42?
It would be nice to see even if speculative, safe ways to build our immunity and your most current recommended protocol for personal protection within in a chart at the end of each video?
Wondering how we can naturally increase nitric oxide, or lower homocysteine levels. I know your focus is not the general public but you seem to be putting more good information together than anyone and wish you could get to the White House task force.
Could this be true for other viruses to such as the strain of viruses that causes the common cold? We were told from an early age that we should take Vitamin C – Ascorbic Acid which is an abundant antioxidant, to veer off getting the cold. Could the same mechanism be at work with the family of the influenza viruses?
In the JAMA article around 12:30, they find that certain pre-existing medical conditions are more prevalent in COVID patients than in the overall population. However, we know that COVID19 patients are biased towards the elderly; it has been suggested on this channel that a decreasing innate immune system may have a lot to do with that. So how common are these conditions when compared to their prevalance in an age adjusted population. So for example, by how much are COVID19 patients more likely to have HTN or CAD than a randomly chosen set of people with the same age profile? (Comparing the norms for the geographic area is helpful, but the age bias may be even bigger).
Doc pardon my ignorance but can AT 1-7 be produced outside the body and injected into a patient?
So if smoking increases the risk of ECD, why the French are trying nicotine patches as a treatment, and why smokers are not in the higher risk group?
What’s your thoughts on taking l-arginine or a glass of red?
Any credence to the reports that smokers end up in the ICU with covid at a far lower rate?
Thank you so much for these amazing videos! You’re a phenomenal educator. What are your thoughts on using Resveratrol to proactively reduce oxidative stress on the cells & potentially create a buffer to the effects of Sars Cov 2? This study suggests that Resveratrol is effective in reducing ROS. https://www.ncbi.nlm.nih.gov/pubmed/13679076. In addition many studies have shown that reducing caloric intake by 20% will stimulate stem cell growth & reduce oxidative stress. Could intermittent fasting also offer a natural protective practice?
This is in line with a recent letter reporting a significant positive correlation between selenium deficiency and COVID-19 death rate ( doi.org/10.1093/ajcn/nqaa095 ), because the essential trace element selenium in the form of selenocysteine, is essential for several selenoproteins which play a pivotal role in antioxidative defense, including five types of glutathione peroxidases (GPxs) and three types of thioredoxin reductases (TrxRs).
Sounds like the connection is that reactive oxygen species and more oxidative state ends up with atherosclerosis. Was this investigated because the symptoms we were finding in the “some patients not doing so well” were myocardial infarction, stroke, etc?
I have absolutely no idea what you are talking about 99% of the time but I am 100% impressed by your output and insights. Humbling is what it is. You are an incredible person. Lets hope you can find an effective treatment to reduce the mortality in this horrible disease. Keep up the great work.
Hi Dr. Seheult, Are you concerned about the wide-spread use of body temperature and thermal scans (airports, ect.) as a sole means to R/O Covid-19 infection and false negatives? I ask because of the JAMA article you discussed in the podacst yesterday, finding that a majority of patients were afibrile at presentation, especially as sick as they had to be. Thank you.
Hyperbaric oxygen is known to increase antioxidant defences. It was explored during the 1918 flu and used with some success.
So how does this new information change treatments and prevention?
Years ago my father had a DVT and lost his leg. It’s been interesting to learn about the processes that can lead to thrombosis.
Dr. Seheult! Wow! Please view this video from University from Japan. Gifu University Antioxidant research department. I can’t believe another dr from across the world is saying the same thing as you are. Unbelievable! Keep up the great work. https://www.youtube.com/watch?v=Nt8F76c0Hsk
Magnificent work, Dr. Seheult. Bravo!
So…if I got it right…there is a potential new option here for treatment by increasing inner Nitric Oxide production.
Great videos …. I only watch your updates for Covid 19. I appreciate all the hard work behind the scenes. Thank you so much.
Take your vitamin C!
Thanks for all the research and references.
Terrific review, as always. One disagreement: the position that whole grains and fruits are important elements in a healthy diet is an increasingly controversial one – yet is presented in the Hindawi article (and seemingly/indirectly endorsed in this video) as fact. There is growing evidence, obviously highly contested, that grains are pro-inflammatory.
I agree with Rt L whole grains and carbohydrates in particular using the dietary guidelines of the US are problematic. As a scientist I find conflicting data that does not support author’s assertion in the review article citing the advantage of ingesting whole grains, as well as giving a bad rap to fats and and protein. there are also genetic components and many other factors to consider. moreover, the data just doesn’t support it . However, reactive oxygen species and the connections to SARS-CoV2 highlighted by Dr. Seheult is a compelling link and pretty important! Carbohydrates taken in large quantities regardless of whether the that is in the form of some fiber rich foods, whole grains can be pro inflammatory!
Seems to be the least of our worries when 42% of the population is vitamin D deficient rising to69% Hispanics, over 70% of elderly and 82% of blacks. There is now a study on vitamin D and COVID-19 which I guess they are pushing for some results by June 30 but there is no reason to wait… We don’t need conclusive proof about a dozen ways to build immunity. What we need is the government to support doing what is safe and shown to be helpful in so many studies over so many years it’s no time to be worrying that vitamin D appears to be the only double blind study that shows very significant health outcomes improvements when supplemented and all of Medcrams good work on sleep, alternating cold and hot showers, The supplements he recommended, etc. but unless the CDC is willing to stick their neck out and tell people that these things are worth a try we are left to Google it and get confused. No one knows the full whole grain story… and it’s too hard to come to firm conclusions on any one thing for anyone in particular concern. Many of us know the essentials of health and choose a different path but many of us don’t know and would choose a better path if felt they were informed from an official source which remains silent (and deadly)
@Kathy Bradbury Would produce less, perhaps; not ‘wouldn’t induce’.
I think we’d find that grains grown in a non-toxic environment wouldn’t induce inflammation.
Depends upon the type of grain and how it is processed and how it is cooked. Each of these factors makes a difference. Look up the peer reviewed research. Turns out the first pass at grain was too simplistic, picture is more complicated.
You are truly a gifted explainer and educator. as well as having seeming boundless energy!!!
Can this Angiotensin 1-7 be administered externally? If the body on its own cannot produce it because of the damaged ACE2, maybe external administration of it might help pull the sever cases through and buy them time for natural immunity response to kill off the virus?
These cliffhangers!!!
I knew alot was going on in our bodys but hearing all this is amazing it makes me want to do my part as the brain of the whole operation and take better care of myself.
I learned that diabetes (T2DM) is caused by fat blocking insulin receptors.
Can fat block ACE2 as well?
So what do you think happens when ACE2 is over expressed due to ACEI medication? Anti inflammation Through stimulation NO and Vasodilation?
Well not for long. There must be a balance between Th1 and Th2 immune cells. With ACEI’s Th1 becomes dominant. Explaining perfectly cytokines IL6 IL1B TNF-A storm and over expression Vasodilation.
Here you have your COVID19 hypotension, sepsis, organ failure patients = Th1 over expression due to ACEI’s
All the ACE2 protection through ACE inhibitors research is mostly based on weeks and relative young metabolic syndrome patient’s. And not months, years of blocking ACE inhibitors in elderly, changing the positive into a negative outcome. No, chronic high blood pressure is not a healthy symptom. But a mechanism from the body to make sure blood flow is prioritized.
Blocking that process without understanding the why’s, is falsely thinking that the body makes mistakes in search of homeostase.
Oh and ACE inhibitors chelates iron, copper, zinc, magnesium, chloride, sodium ions. ACE enzym is a Metallo depended zinc, chloride enzyme. Perhaps it Sounds like a good idea to chelate excess positive ions, that normally in people with hypertension reacts with oxygen making ROS.
But again what happens after months, years, in metabolic people when Th1 become dominant, and kidneys can’t filter ACE inhibitors properly? And what about our little diuretics friends? Flushing away more minerals and even Thiamine, vitamin B1. And when zinc and chloride and all the other metals for antioxidant protection, and to make ATP is becoming excessively low? What happens then?
Flushing out to much sodium and water will damage the glycogalyx even more.
ACEI’s are not regulators, the block enzym activity. That’s a huge difference.
Come on your smart enough.
We know wich people die from, or with corona.
It’s the metabolic syndrome people with mostly poor kidney function, and on lowering blood pressure medicines.
And that those people can produce the same symptoms, even before anybody heard about SARS covid19.
17:27 , I left this comment on your previous video. “I believe red light therapy creates nitric oxide. The way I understand this is; light in the 660 nm range or the 850 nm range liberates NO bound to mitochondria. Then Oxygen replaces the NO that was liberated from the mitochondria. So, your body is able to tap into a source of NO and respirate the mitochondria at the same time. I have a couple devices that shine the red light I specified into a nasal port. The 660 nm red light (and the 850 nm to a lesser extent) nasal port does lower my blood pressure after I use it. I believe this is the result of the liberated NO I previously described. Natural sunlight would include the specified wavelengths of light, but the nasal port is more convenient for me.”
I mentioned this treatment to a Doctor in Emergency at Byron hospital Australia when i cut my hand as to why i feared no infection, HE WAS SHOCKED AT HOW SIMPLE IT WAS PLEASE LOOK INTO IT …..
Hi …. just mentioning AGAIN that I was horrifically effected by H O ( oxidative stress) and discovered breathing inert Hydrogen and Oxygen through a machine from Hydrogen Technologies Cairns Queensland Australia. …….. it seems to do the same thing that you are referring to, but easily and quickly. I went from being unable to breath to bounding up hills at 52, I have only been on it for less than 12 months. I BELIEVE IT CAN SAVE L;IVES and there are pier reviewed papers on it.
I was losing hair in handfuls had skin cancers popping up everywhere (MNWC) staff infections with a scratch and terrible fungal and bacterial infections in the mouth. I felt like I was drowning as I couldn’t seem to get oxygen when breathing then after just weeks of breathing this inert H gas i began to heal like a reverse ageing even my grey hair began to reverse. I had struggled with nutritional intake and had major prolonged stress over 8 years am super thin and have smoked. I thought I had emphysema but now my lungs are dry and functioning reasonable well zero infections of any kind and any virus is short lived unlike my past. Skin cancers reversing some already gone, fluid in my fingers, gone, even my irregular heart beat is gone……. I could go on and on but you get the picture.
@E. Lee International Journal of Clinical Medicine, 2016, 7, 32-76
Published Online January 2016 in SciRes. Clinical Effects of Hydrogen Administration:
From Animal and Human Diseases to
Exercise Medicine http://www.scirp.org/journal/ijcm
http://dx.doi.org/10.4236/ijcm.2016.71005
https://www.frontiersin.org/articles/10.3389/fonc.2019.00696/full Hydrogen in cancer treatment found in fronteirs of Oncology .
I haven’t looked too deeply into the science as I am just living it and seeing the results I am my own quantitative experiment but you can go from there.
Please put a link to the studies so people can follow-up. Thank you.
Thanks again.
I am amazed at how it looks like you are putting this all together.
Do you think that this is why IV Vitamin C has worked well? Is it a general quencher of ROS (and thus could reduce superoxide) or does it have a more specific target and thus less likely to help here? Also, it looks like things that can stimulate not only NO, but glutathione will help alot.
Have your patients seemed like they have high altitude sickness as some NY docs have said?
Regarding the profile of pre-existing conditions (11:55), I assume that most of these patients had more than one condition, yes? If so, how many of them had just or more of the conditions on the right? I know COPD is already equal to the rate in the general population, but it still might provide stronger evidence to know the answer.
Good question. Off hand I don’t know. But looking into the JAMA article I remember it was listed.
This is a good time to be on a whole food plant based diet.
Or on a meat and lots of fruits & vegetables diet.
Another incredible opus ! Thanks a lot from a practitioner in Paris. As I asked in the comments in your webinar : would you recommend Glutathion or Nacetyl cysteine supplementation ? Keep on !! Cheers.
Holding my breath … THX !😀
I think all the antioxidants might be beneficial. More on this….
NAC is better absorbed and then turns into glutathione, but it looks like it does not directly act against superoxide, so it won’t do as much good as perhaps boosting NO production
When hypertension is listed as a risk factor for covid-19, does that include controlled hypertension? I’ve been taking daily valsartan and I keep my BP within normal ranges. Is my controlled hypertension a risk factor?
Also this about ACE inhibitors that was released 8 hours ago.
https://www.nytimes.com/2020/05/01/health/blood-pressure-drugs-coronavirus.html
Just found this from the British Heart Foundation –
“I have high blood pressure – am I at risk from coronavirus?
High blood pressure (hypertension) is associated with increased death rates in people who have Covid-19 infection. This is based on data from large Covid-19 research studies which report population-level figures. So it’s not easy to apply that directly to your individual level of risk. The statistics that we have are not able to tell us whether there’s a difference in Covid-19 complications between people who have controlled or uncontrolled high blood pressure. But it may be that if you have well controlled blood pressure (in other words, your blood pressure has been brought down by medication to your target level), and you have not had complications caused by high blood pressure (such as thickening of your heart muscle), then your increase in risk is relatively small’
I think the general consensus at the moment is,like with a lot of things Covid related,they dont really know. But a lot of the reasoning I found was that a lot of the people who are dying are older-hypertension is very common in older people-therefore hypertension is the most common co-morbity with covid. A lot of what I read says that it depends on what is causing the hypertension in the first place.
Ive been trying to find this out for weeks too.
I’ve tried to get that answer.
Doctor, how do you counter clotting risk in infected but otherwise healthy patients, with good weight, exercise and eating habits, etc., but carrying a significant genetic factor creating DVT unless they’re on medication (for ex., Eliquis)? Is such a patient likely to remain on his Eliquis throughout COVID 19 treatment? Can Eliquis naturally help treat COVID 19-related clotting? This is a 65 year old man. Thank you.
what do you know about Favipiravir?
Thank you
Much better than your live Web. Not a dr. So… Question: What exactly are the mitigating anti- oxidents one could take?
It is looking like boosting NO production might be helpful, so citrulline, arginine, AAKG, and maybe eating things like ARUGULA, Dark chocolate, maybe pomegranate, Vitamin E,
Who is that one person who disliked this video?
@vgernyc we are coming for you
Winnie the Pooh: “Me too”
SARS-CoV-2: “Me”
Doc, you are such an awesome teacher. I wish you were here in Miami but glad to meet you on Youtube.
Lung patients are so aware of their illness and warned by their medical professionals, they knew to stay in and protect themselves?
Maybe someone took it to them
No, apparently it has less to do with the lungs than we previously thought. It mainly attacks the cardiovascular system, and in the last stages before death, very late in the course of the disease the lungs get destroyed in the process.
Is it possible that the combination of leronlimab and curcumin can treat Covid-19 ?
Dr.Bruce Patterson (Professor of Virology at Stanford School of Medicine) “Leronlimab (a CCR5 antagonist), offers a triple threat solution to SARs Cov 2 by reducing inflammation (by actively calming the cytokine storm), enhancing the immune response, and reducing the viral plasma load. The combination of these 3 has not been seen in any potential treatment being tested in ongoing trials”
Curcumin induces glutathione biosynthesis- https://www.ncbi.nlm.nih.gov/pubmed/15650394
“Curcumin interacted directly with superoxide anion (O2*-) and hydroxyl radical (*OH) as shown by electron paramagnetic resonance, quenching the interaction of the radicals with the spin trap, Tempone-H. This suggests that curcumin has multiple properties: as an oxygen radical scavenger, antioxidant through modulation of glutathione levels, and antiinflammatory agent through inhibition of IL-8 release in lung cells.”
Rt L piperine, found in black pepper, increases the absorption of cucumin by up to 2,000% https://www.ncbi.nlm.nih.gov/pubmed/9619120
So add some black pepper to your cumin spiced curry, Or try a breakfast smoothie with cumin, and black pepper, plus some beets and antioxidant blueberries and oranges (ref from Nutritionfacts.org )
@Rt L Yes turmeric alone won’t suffice. There has been recent discovery that black cumin seed oil (fatty lipid) has shown to dramatically increase the bio-availability of curcumin. There are vendors that sell the supplement with the added ingredient: https://www.amazon.com/Smarter-Turmeric-Curcumin-Curcuminoid-Curcuminoids/dp/B074MJND9Y
I take Turmeric, but my understanding is that it is poorly absorbed (and that it may take heroic doses to make a difference).
Is it possible that a single virus (SARS COV 2) can cause different illnesses in different receptors?
Brilliant! I watch your lectures everyday. Thank you!
Thank you, doctor. Your work is greatly appreciated.
Dr. Seheult,
thank you for this great explanation.
To improve your work I would advise you to have a closer look at the role of PUFA’s in the electron leakage of the mitochondria.
It would mean the chart showing good and bad food is wrong and glucose and PUFA’s are the real culprit to HT and CVD raise in the last 50 years.
Here is a great video conference stating this point: https://www.youtube.com/watch?v=pIRurLnQ8oo
Besides that point, you really are a great information source in this COVID crisis and I thank you again for that.
Cheers
JXO
Hmmm…… seems like boosting NO is going to be critical. Citrulline + Dark Chocolate (or even better unsweetened baking chocolate) might be helpful.
or how about not eating junk food and getting fat, or smoking.
or daily cialis/viagra
Are you ever going to address this study
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3580524
Nice and informative presentation. Please explain the formation of clots if possible in the way you’re presenting oxidative stress… thanks a lot and all the best Doc …….
Yesterday’s Covid -19 webinar -also on YT went into it in detail.
I take lisinopril. If it blocks ACE 2, then why is that a good thing??
It doesn’t block ACE2. It inhibits ACE. Which then leads to overexpression of ACE2, which seems like it may end up being helpful.
You’ve finally done the math I was waiting for someone to do. Comorbidity stats general population vs hospitalized covid patients. With such a comparison one could poshilate that a hypertensive patient has double the risk of being hospitalized if they get covid.
@A G Maybe they were smokers, as that damages the cells involved in preventing small blood clots.Smoking is a big factor in blood clots. Or there may be genetic differences. The research presented on blood type demonstrated that, Genes-blood type- level of the amount of a specific protein that was important in the expression of another protein.
What is puzzling about this is why then are some young relatively healthy patients developing such severe cases leading to strokes, blood clots in legs, and even leg amputations?
There appears to be some general correlation between low national levels of obesity & the countries which are doing best at combating Covid-19. However, it’s a pity that China & Taiwan don’t contribute to the global obesity stats published by ProCon.Org which could perhaps further support that correlation. Of course obesity is just one factor in this topic, but of the 10 OECD countries the US has the highest % of obesity, tho’ globally it is the triangle of many Polynesian islands which fortunately have very low reported rates of Covid-29 total infections.
Angiotensin II is responsible for increased vascular volume by increasing sodium and fluid retention. Many African-Americans are salt retentive. Glucose-6-phosphate dehydrogenase deficiency is genetic. The deficiency is more prevalent in Africa and more commonly found in men.
It is mentioned that people with diabetis or high blood pressure are more at risk. Would that include patients that take medication, and are in a normal range of blood pressure and/or blood sugar? Or is their risk lower?
I just wonder, if, after two years of low carb diet, and very well adjusted blood sugar and blood pressure readings, the damage done to the blood vessels deminished. (Sorry, no MD)
@A G I have read/seen excellent studies that address the mechanisms of the condition that causes metabolic syndrome and insulin resistance (and therefore the subsequent diabetes/hypertension/obesity). Low carbohydrate (aka ‘low carb’, ‘vlc’, ‘lchf’, ‘keto’, ‘ketogenic’, etc.) diets high in healthy fats and moderate in protein are indicated. As with Medcram, the channel ‘Low Carb Down Under’ (no direct affiliation or financial interests) on youtube also has a veritable treasure trove of lectures offered by esteemed physicians and medical researchers. I cannot recommend it highly enough. There are also vegan options for such a lifestyle; easily searchable online.
Thanks!
This is a very good question that never seems to get answered. Unfortunately, my understanding is that the conditions of the body that lead to diabetes and hypertension are perhaps what make these people more vulnerable than whether they have their blood pressure and their blood glucose under control. These are both examples of metabolic syndrome which is probably the overarching condition that makes them vulnerable to a more severe case of covid-19. Hypertension and diabetes are really just consequences of metabolic syndrome and insulin resistance.
G6PD testing is given to any enlisted person before deployment to a malaria-prone zone. G6PD deficiency is of higher prevalence to African and Mediterranean decent folks.
Thanks a lot.
Merci beaucoup
Heart disease is not caused by cholesterol. The vessels crack because of low vitamins like d, c, zinc. Sugar is not food. Covid acts like heart disease. Imo whole grains are crap. That is sugar. Vegetables, meat, just a little fruit,dump sugar and processed crap. It isnt cholesterol ,it is triglycerides sugar that is problem.
Who told you heart disease isn’t caused by cholesterol? Cholesterol is what accumulates in the artery plaques
So… from a lay person.. what do we know and where do we go?
@A G so 85% dark chocolate?
watch yesterday’s Covid-19 webinar (hour & 1/2 goes into all of that.
It’s looking like ramping up NO production (perhaps by citrulline and cocoa polyphenols) will help, maybe some antioxidants might be helpful (such as vitamin E which is known to reduce blood clots).
You the Best of the Best and SARScov2 is afraid of your abilities to explain its nature clearly..
“In combination, L-arginine and BH4 inhibit superoxide generation by decreasing the rate of NADPH consumption and by generating NO.”…..”The present data indicate that L-arginine controls the generation of superoxide by decreasing the rate of NADPH consumption, whereas BH4 controls superoxide formation by promoting the formation of heme-peroxo species.”…
https://www.jbc.org/content/274/38/26736.full.pdf
Doctor, from my understanding of how this virus works(I’ve been researching it since February and came to an endothelial conclusion after the iron homeostasis reports and ironically you came out with your video a week later), it seems that Citrulline, as an NO precursor that bypasses certain processes this virus seems to take(also a REDOX), Alpha Ketogluterate(Krebs cycle, REDOX), and high dose Vitamin C(BH4, REDOX) would be very beneficial either preventing severity or possibly treating severity. Do you have any thoughts? Thank you
@MedCram – Medical Lectures Explained CLEARLY Fantastic. I’ve also heard L-arginin is needed for viruses to replicate, or is this not true? Should one take or stay away from L-arginin?
Since citrulline, AAKG, and arginine are very big supplements in the weightlifting and bodybuilding communities it would be interesting to know if they have very mild covid=10 symptoms.
Ah very interesting. I’ve been thinking of the benefits of citrulline too.
It’s possible. I’ll look into it
Impressed he is back the day after the webcast! Still buzzing? :))
Thank you for keeping us up to date!
Well, i dont really know what conclusion i draw from the numbers at 12:55
57% of patients had hypertension compared to 29% in the general population.. Looking at this straight on, it seems like people with hypertension is in greater danger of ending up in the hospital.. BUT.. Cant it just be that the virus causes hypertension, thus leading to many more people showing hypertension (when sick with covid19) in the hospital, compared to the general population, instead of them already having hypertension before they got sick?
@MedCram – Medical Lectures Explained CLEARLY I am 150 pounds and a very slim athletic 42 year old, My systolic/diastolic ALWAYS are sky high on every occasion whenever i present at the Doctors office (mental white Coat) but i get home and take it on my machine, where I am actually relaxed and it reads normal again, so the doctors office is not a good test for me on any occasion.
Your’e not alone, my thoughts exactly.
Hypertension is not usually diagnosed by an acute rise in bp but rather on 2 different occasions in a doctors office under a relaxed state.
Thank you sir…
Hello Dr, thank you for another amazing video. What are your thoughts on TNF blockers (enbrel from example) as a possible treatment?
So how to increase NO in the blood? First eat lots of nitrate-rich greens and/or beets (but beware too much spinach which can lead to kidney stones). Then stop using antibacterial mouthwash and toothpaste — no really it’s true!
Sources:
https://nutritionfacts.org/video/antibacterial-toothpaste-harmful-helpful-or-harmless/
https://nutritionfacts.org/video/kidney-stones-and-spinach-chard-and-beet-greens-dont-eat-too-much/
@Ruud the Diamond So true!
@Debi Caldwell I learned a lot from him.
Cool, learning a lot here. So an arugula pizza or salad, al fresco, with chocolate for dessert. Sounds like a plan.
@A G you can’t really eat a pizza slice without some arugula and extra virgin Oliver Oil:)
Also sun exposure. UVA activates NO in our bodies.
https://www.wikiwand.com/en/N-Arachidonoyl_dopamine
On that note, I think I’m gonna have me a nice Malbec.
These updates help because I have no medical training however being in this risk group I can still understand the ramifications. The videos encourage me to stay away from others because time is my friend. Each week more is learned about what is happening in the body so you guys have more information to help you with this Covid-19 puzzle. I really appreciate everyone at MedCram working so hard on this project and the website. So many involved and working so hard. Thanks.
If you are in this risk group, look up the keto diet and look up intermittent fasting. Both can start moving your cardiovascular system in the right direction.
Well, I am not a doctor yet but I am certainly more knowledgeable.
Camphor acts like surfactant and has anticoagulant properties.
And what should we eat? https://youtu.be/EqKNfyUPzoU?t=675
Once again an excellent video – many thanks for exploring ROS and co-morbidities on the impact of COVID-19 illness.
Are you able to comment on the place of statins on ACE2, AT 1-7 and ROS production?
Fedson DS, Opal SM, Rordam OM. 2020. Hiding in plain sight: an approach to treating patients with severe COVID-19 infection. mBio 11:e00398-20. https://doi.org/10.1128/mBio.00398-20.
I don’t understand how you’re mentioning the addition and loss of electrons yet atoms appear and disappear; I assume there are the necessary chemical reactions, but the lack of mention makes it a bit difficult – I’ll take this as beyond the scope of illustration.
Thanks
There are many saying that Covid-19 stays in our system and will resurface, that it doesn’t go away and there is no herd immunity. Can you explain this?
Wes thank you…..I will share this. There is too much apocalyptic like fear being said of this virus.
@Javier Correa Read wes’s post just above yours. He explains & provides a link to where they explain how that claim came about. Claim of reinfection is not true.
@Wes Yes the quality of the testing kits is very varied.
Who said that and what is their evidence? Stop spreading fake news.
Good news on that front: One of the biggest pieces of evidence towards the reinfection theory was a Korean report suggesting that a significant number of patients had tested positive once again after testing negative twice and as such being considered recovered. Over 180 in the initial report, which climbed to over 260 instances since.
Korean researchers have looked into it in more detail and now they’ve determined that false positive testing from dead virus fragments is the likely cause of these positive ‘reinfections.’ This is bolstered by the fact that these patients are not actually showing symptoms again, despite testing positive.
https://www.businessinsider.com/coronavirus-south-korean-reactivated-cases-not-reinfected-experts-2020-4
Question remains how LONG people will retain immunity to the virus, but at present it does appear that the body does clear the virus and develop at least some lasting immunity.
Very interesting lecture….have a great weekend and thank you ..from Ireland
Dr. Seheult thank you for all the great information that you are sharing with us.
Virtually every article or video that I have seen so far divide all Covid-19 patients into those who survived and those who did not. Can you please address the possible treatments for those people who already went through the sickness and survived but are severely affected with shortness of breath, sleepiness and/or other symptoms as a consequence of Covid-19.
Tbh I hit the like button before the video even begins, and I haven’t been let down yet.
Great nfo again – I´ll include some easiest, simpliest recepies with the protocol I promised 🙂 but here one product that´s ready to use – and delicious:
Dr Mercola´s Fermented Beets with Red Spinach contains both organic fermented beet powder and red spinach extract for one of the most powerful, complementary nitric oxide formulas ever.
And forgot one option: a lot of extra virgin olive oil, the stronger taste the better.
And ofcourse forgot: curcumin (reguires cooking).
Oh no, I must add one simpliest ever soup recipe now for you for the weekend:
2 kg beet, 2 kg onions – peeled, sliced and cooked for 3-4 hours, sguash with blender. Make variations: sometimes add dried rosemary (requires cooking), sometimes organic cream (after cooking), sometimes Garam Masala (requires cooking), sometimes organic soy sauce, sometimes sour cream eye (on the soup when on the plate). Warning: can cause addiction ;p
Must add: nothing beats the beets 🙂 for many reasons.
Explains why children and young people have been mostly unaffected or recover in less time. Still don’t know why so many people are asymptomatic. Unless they eat a lot of hot dogs 😉
@Ruud the Diamond The Netherlands doesn’t ever seal juvenile records? Weird.
The conclusion I drew from these videos is that COVID-19 deactivates the body’s natural mechanism for manage oxidative stress. So if you don’t have a lot of oxidative stress from things like hypertension, obesity, or other sources, then COVID-19 doesn’t really seem to do much, since you body didn’t have much oxidative stress to worry about anyway. Younger people typically don’t have much oxidative stress, while older bodies are more prone to the other conditions where the oxidative stress goes to town on you if your body’s defense against it shuts down.
Does that sound right?
Asymptomatic carriers probably have a strong immune system, so they carry this monster virus in their nose/throat and spread it to others without experiencing any symptoms themselves.
@Moe J. thanks
@Ruud the Diamond wow
After listening to Dr. Seheult I stay after class and read all the comments hoping to learn more.
While eating beets today.
Beets are rich in natural chemicals called nitrates. Through a chain reaction, your body changes nitrates into nitric oxide, which helps with blood flow and blood pressure.
Charles Shamseldin Beets are rich in natural chemicals called nitrates. Through a chain reaction, your body changes nitrates into nitric oxide, which helps with blood flow and blood pressure.
@Charles Shamseldin I honestly wonder if this contributes to Russia having such a low death rate
lol nothing like great vegs.
VEGGATRON it’s about as high or higher in NO than anything else out there.
Dr Medcram – while adding electrons to oxygen, does a proton get added as well? Suddenly we went from just Oxygen with added electrons (super oxide) to H2O2. How does the H magically appear?
girlgeniusNYC He explained it a video or two before this one. You have H+ in the cells.
Are you using IV Vitamin C to treat COVID-19 oxidative stress? They were using between 24 and 50 grams per day in China, depending on severity of disease. 👍
Go back and view the earlier videos, this was covered in at least two.
Thank you for uploading your webinar. I really appreciate the effort you put into your research. I have been talking to my colleagues regarding oxidative stress.
Does whole grains really reduce oxidative stress when whole grains dramatically increase postprandial blood sugar?
I really thought you were going to rest today after such a big day yesterday but yay thank you.
loved it
excellent 👌
I have been using SOD supplements. Is that any good?
Probably a good idea.
People: Pays attention to Dr. Seheult’s explanation
Me: Wonders how he could draw such straight lines
Sorry but I’m just as amazed… lol
Have you seen his ellipses? He goes over it twice with minimal deviation. I bet he draws or used to draw allot.
Martin S He’s probably studied Art!
@js0590 😂 😂
He pretends to be Queen Elizabeth II, so he knows how to be a ruler
Is it possible to make ace2 and give it to patients?
@A G nice, hope it will be a step towards an easy cure
@Ole Sauffaus Actually, they can give the ACE2 enzyme to patients through an iv infusion.
They are currently doing a study on giving patients recombinant ACE2 iv infusions. One of the other doctors on YouTube mentioned this a few weeks ago and said that he thought this is what would work against this disease, and now it looks like he was right.
@Harold Kuilman … I can’t answer that … maybe I’m wrong, and the ACE2-receptor is something different from ACE2 itself … I’m not sure :/
How does it change the AT-11 into AT-1,7? In this triangle shown in the video
covid 2019 assicoaiyred increase glucose levels and cholesterol build up accumulated on lumen epitllium off lung cells and their oxidative stress associated LDL- which associated with regulation in ACE 2 and LDL and interaction swith NADPH
What is Lipitor? Lipitor (atorvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or statins. Atorvastatin reduces levels of bad cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of good cholesterol (high-density lipoprotein, or HDL). Lipitor is used to treat high cholesterol , and to lower the risk of stroke, heart attack, or
this acts as increasing the HDL in blood and to reduce LDL receptors binding reduction that inhabit oxidative stress and lowe r change of ARDS AND ASSOCIATED RESPIRATORY COMPLICATIONS
by implementation reducing of cholesterol will lead to reduced possibility of oxidative stress which results in build up of inflammation thrombosis and asestrois where built up plaque..
Statins have not been found to do much good against covid-19.
taresy6789pp Pang Stunning response brother – tell us more
dr brownstein seems to be helping patients -https://www.youtube.com/watch?v=YYiFuWa5ito
Good idea
Webinar was fantastic! Thanks!
I’m going to be a doctor soon at this rate…
@Laura Carson By teaching, or passing it on, we learn deeply and retain a better understanding…IMHO
Hahahha. I sound like a doctor explaining to my family and friends some of the things I pickup form these videos 👍 👌
Funny, I have been thinking the same thing and this is not the only channel like this I follow. Every day I turn around and give my husband and friends the cliff note version and a compilation of everything I’ve heard on the channels I follow.
@Concerned Citizen You can get your medical degree in Romania for a fraction of the cost. As soon as we are allowed to travel 😒
You can’t be a doctor by just watching these lectures. You need a medical school bill ( debt) ( about $500,,000) to become a full fledged MD…….
Is okay to take Reduced Glutathione tabs?
NAC is better. But it appears that Superoxide is not directly effected by glutathione. And it appears that superoxide is what is causing most of the problems.
TheOlzee thanks! just wondering about Reduced Glutathione tabs.. 😊😊😊
Are they even bioavailable? NAC Zia always ok to take imo
I’m excited to be early today !!
AAPS covid report just released… can you review this info for us
Astazanthin
Astaxanthin is a powerful antioxidant. Plus maybe a natural form of vitamin E which is a powerful antioxidant and reduces the formation of blood clots.
Thanks and happy labor day, from Guatemala
Hi Marcela, for some reason Americans celebrate “Labor Day” at the end of May 🙂
Thank you for these videos! 🙏❤️
Thank you. Loved the webinar.