COVID-19 Update 67 with critical care specialist and pulmonologist Roger Seheult, MD of https://www.medcram.com
After an update of global coronavirus infections and deaths, Dr. Seheult continues his review of journals and illustrates more of the possible pathway for blood clot (thrombosis) formation in COVID-19. See how oxidative stress of the endothelium (lining of the blood vessels), Von Willebrand factor, racial differences, and blood types may have a significant effect on COVID-19 severity and fatality rates.
Links referenced in this video:
Johns Hopkins – https://coronavirus.jhu.edu/map.html
https://www.worldometers.info/coronavirus/
Karger – https://www.karger.com/Article/PDF/73600
Pathophysiology of Haemostasis and Thrombosis – https://www.ncbi.nlm.nih.gov/pubmed/13679676
Thrombosis Research – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156948/
Intechopen – https://www.intechopen.com/books/endothelial-dysfunction-old-concepts-and-new-challenges/endothelial-cell-von-willebrand-factor-secretion-in-health-and-cardiovascular-disease
Science Alert – https://www.sciencealert.com/paper-suggests-certain-blood-types-might-be-slightly-more-susceptible-to-covid-19
medRxiv – https://www.medrxiv.org/content/10.1101/2020.03.11.20031096v2.full.pdf
Thrombosis Journal – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042969/
Journal of Thrombosis and Haemostasis – https://www.ncbi.nlm.nih.gov/pubmed/32220112
CDC – https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/racial-ethnic-minorities.html
Some previous videos from this series (visit MedCram.com for the full series):
-Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs – Hypertension Medications with COVID-19 https://youtu.be/OudhmwulJHY
-Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors) https://youtu.be/gzx8LH4Fjic
-Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update https://youtu.be/Z2hfGcTokiY
-Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress https://youtu.be/22Bn8jsGI54
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://youtu.be/fn2yk5SbGiw
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) https://youtu.be/NM2A2xNLWR4
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion) https://youtu.be/nO4xgcIaPeA
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
– Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
– Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?: https://youtu.be/kgzFAdYwYLM
– Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?: https://youtu.be/o8aG63yigjA
– Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: https://youtu.be/qc6VV7ue4cE
– Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: https://youtu.be/E7MufS6dnJw
– Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: https://youtu.be/fya6Zwxch88
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
Many other videos on COVID-19 (coronavirus outbreak, corona virus symptoms, influenza, coronavirus epidemic) and other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com
Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at [email protected] if you are interested)
Media Contact: [email protected]
Media contact info: https://www.medcram.com/pages/media-contact
MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus
Thank you for supporting our frequent COVID-19 updates by subscribing and visiting us at https://www.MedCram.com
At our website, browse all of our videos and CLEAR explanations of over 60 medical topics. We also offer CMEs for medical professionals, and group rates for medical programs and institutions.
All links referenced in this video are in the video description. Quick links to our previous updates on the coronavirus pandemic:
– Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs – Hypertension Medications with COVID-19: https://youtu.be/OudhmwulJHY
– Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors): https://youtu.be/gzx8LH4Fjic
– Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update: https://youtu.be/Z2hfGcTokiY
– Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress: https://youtu.be/22Bn8jsGI54
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? https://youtu.be/fn2yk5SbGiw
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC): https://youtu.be/NM2A2xNLWR4
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion): https://youtu.be/nO4xgcIaPeA
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
– Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
– Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing? https://youtu.be/kgzFAdYwYLM
– Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse? https://youtu.be/o8aG63yigjA
– Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: https://youtu.be/qc6VV7ue4cE
– Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: https://youtu.be/E7MufS6dnJw
– Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: https://youtu.be/fya6Zwxch88
– Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): https://youtu.be/uaIzj3s3p4A
– Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: https://youtu.be/JN-8bGB1cLM
– Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu: https://youtu.be/H1LHgyfPPQ8
– Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine: https://youtu.be/EFRwnhfWXxo
– Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention: https://youtu.be/G1zsE9_85i4
– Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful? https://youtu.be/A4eu-h_owaI
– Coronavirus Pandemic Update 43: Shortages, Immunity, & Can a TB Vaccine (BCG) Help Prevent COVID-19? https://youtu.be/LqKwAIIy-Mo
– Coronavirus Pandemic Update 42: Immunity to COVID-19 and is Reinfection Possible? https://youtu.be/q4P91VrfPGw
– Coronavirus Pandemic Update 41: Shelter In Place, FDA Investigates Hydroxychloroquine for COVID-19: https://youtu.be/hPz5KxgI_K4
– Coronavirus Pandemic Update 40: Ibuprofen and COVID-19 (are NSAIDs safe?), trials of HIV medications: https://youtu.be/dT6mHi_8V5E
– Coronavirus Pandemic Update 39: Rapid COVID-19 Spread with Mild or No Symptoms, More on Treatment: https://youtu.be/AToF8O5T86s
– Coronavirus Pandemic Update 38: How Hospitals & Clinics Can Prepare for COVID-19, Global Cases Surge: https://youtu.be/MoisrCTu0SY
– Coronavirus Pandemic Update 37: The ACE-2 Receptor – The Doorway to COVID-19 (ACE Inhibitors & ARBs): https://youtu.be/1vZDVbqRhyM
– Coronavirus Pandemic Update 36: Flatten The COVID-19 Curve, Social Distancing, Hospital Capacities: https://youtu.be/vww1nIIoqmw
– Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments: https://youtu.be/vE4_LsftNKM
– Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown: https://youtu.be/U7F1cnWup9M
– Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: https://youtu.be/Mm7UrZeu-74
– Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? https://youtu.be/Eeh054-Hx1U
– Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? https://youtu.be/7YI2tOoVVpk
– Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention: https://youtu.be/gmqgGwT6bw0
– Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran: https://youtu.be/XjEacUyp4vY
– Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate: https://youtu.be/quDYb_x54DM
– Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases: https://youtu.be/xQwfuJgJ9lo
– Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic? https://youtu.be/bV1CZxJ-uvU
– Coronavirus Epidemic Update 25: Vaccine Developments, Italy’s Response, and Mortality Rate Trends: https://youtu.be/UImSVhLLeGY
– Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms: https://youtu.be/wFoj2L2LpNA
– Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats: https://youtu.be/JGhwAGiAnJo
– Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing: https://youtu.be/OqpHvK0XADY
– Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?: https://youtu.be/9BYaywITXYk
– Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins: https://youtu.be/Ka48UZDDzLY
– Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials: https://youtu.be/4HK9QEy1KJ8
– Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips: https://youtu.be/vE4pBkslqS4
– Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19): https://youtu.be/wlbM6VVkVZM
– Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19): https://youtu.be/qqZYEgREuZ8
– Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19): https://youtu.be/o804wu5h_ms
– Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks: https://youtu.be/pDnmHu8x9C4
– Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada: https://youtu.be/0UgrPgJdzp0
– Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV: https://youtu.be/GT3_A1bf9pU
– Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine): https://youtu.be/pfGpdFNHoqQ
– Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV): https://youtu.be/gPwfiQgGsFo
– Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate: https://youtu.be/8Hjy3UfaTSc
– Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA: https://youtu.be/GpbUoLvpdCo
– Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding: https://youtu.be/nW3xqcGidpQ
– Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period: https://youtu.be/UGxgNebx1pg
– Coronavirus Update 5: Mortality Rate vs SARS / Influenza: https://youtu.be/MN9-UXsvPBY
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
– Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine: https://youtu.be/SJBYwUtB83o
– Coronavirus Symptoms, Diagnosis, Treatment: https://youtu.be/UCG3xqtcL3c
– Coronavirus Outbreak – Transmission & Updates: https://youtu.be/9vMXSkKLg2I
Cayenne Pepper has been shown to be effective at thinning blood, useful with Thrombisis, Strokes and Heart attacks. Though I enjoy the taste it isn’t something my body likes me to have too often, but better than the issues COVID causes.
MedCram – Medical Lectures Explained CLEARLY Dr Seheult thank you so much! You certainly deliver on your promise of clear explanations. Your hypothesis is fascinating. I wonder if you are aware of a holistic approach by US based YT Doctor, David Brownstein, who has been treating patients with relatively severe symptoms, some on the verge of admission, with ozone therapy, and/or (in its absence), nebulised Hydrogen Peroxide and Iodine in a weak solution, together with Vit D, Vit C, Vit A and Iodine. Testimonials from grateful recovered patients all point to the nebuliser as a turning point in their improvement. Since H2O2 is a ROS, and implicated in the chain of reduction you describe, I am wondering what mechanism might be at work which would lead pts to describe almost instant relief from the nebulising. Here is one one link of several in a similar vein. Thank you for your excellent channel! I watch every day from Australia. 🐨🌷
https://youtu.be/fdat7OrEnK8
Since I am not a medical specialist, I am wondering if it is possible if covid-19 can indirectly “poison” the patient’s blood when it is most infectious? If so, would chelation or blood transfusion help to slow down the infection? Thank you. -Charlene
Update 60, about HCQ “has been removed for violating YouTube restrictions”
Here’s something medcram?
https://www.medrxiv.org/content/10.1101/2020.04.08.20058073v1
Thank you
Why can’t pts with high risk have prophylaxis Hydroxychloroquine to keep on hand? https://swarajyamag.com/insta/covid-19-india-recommends-hydroxychloroquine-as-prophylaxis-for-healthcare-providers-patient-family-members
I have no medical expertise, but I am fascinated by your videos! Thank you so much for the clear teaching and explanations!
This lecture was simply amazing. At one point I actually felt like I could see the Matrix. It’s so reassuring to see our wonderful medical professionals figuring this thing out. I can’t wait to hear about treatments on the next video!
Would appreciate a video on multiple endocrine neoplasia 2a during coronavirus since it’s all a genetic puzzling maze
Hey Doc, a quick question w/regards to the blood groups. Was there any differentiation shown between A Positive vs. A Negative, and so on? Just curious.
I hope those weekly undulations in new cases are not related to weekly patterns of social distancing. If so, reopening the nation could bring another spike. I hope people wear masks and keep their guard up against this virus. At least don’t assume we are out of the woods.
Hope you are familiar with Dr. Mike Hansen…
https://youtu.be/KzKvIYwqQkE
Black people has very low levels of vitamin D
Best episode in the series yet!!!
What’s happened to the UVc light research? I thought if we could get these lights installed in schools, offices, hospitals etc we could all get back to work and the UVc light would kill the pesky virus. Did I just imagine seeing a video about that medcram?
I’m curious if doctors should be testing for von willebrand factor or is a simple D-dimer sufficient in ruling out thrombosis in covid patients?
I really enjoy watching these videos. Have the blood type studies shown a difference between if one has a say O- or ab+ that is does the neg or pos make a statical difference? Or does it not, matter.
How do you explain the blood group AB having the highest VWF ? Blood group AB doesn’t seem to have a worse (or better) morbidity than other groups according to the Chinese meta-survey, yet blood group A does…
0:05 The number of Deaths per million in Belgium seems very high but they are reporting just about every (suspect) covid-19 case whereas other countries do not test as much and only report on tested and confirmed cases. The Netherlands seems to be doing much better then Belgium on this list but actually we are not.
Greetings from The Netherlands 🇳🇱
What about older patients with a pacemaker? More or less thrombus? Effect of Hydroxychloroquine?
These are the most valuable and best presented lectures I have seen on Covid 19. By FAR. As a non-medical scientist, the presentation level is spot on for me – precise and detailed without unnecessary detail. Well done! I don’t need the CME credits and the full access is a little pricy (but tempting). If you were to put a PayPal Donate button on the talks, I would press it more than once. Please give me a way to support your Covid work and show my appreciation.
Silicic acid might help. It reduces AT.
Great video today
https://youtu.be/gQYPi0Wm6OE
I don’t want to see Chinese studies, no point of looking at their studies at all. They are not to be trusted whatsoever.
Thank you for hosting this journal club 🙂
In the late 1980s, prior to med school I was a grad assistant in the lab of Dr Alan J Lefer Dept of Physiology Thomson’s Jefferson Univ in Philadelphia PA. We did many studies elucidating the functions and mechanisms of the endothelium. Nice review of the work we were doing back then showing that the endothelium was not just a lining but a very important factor in vessel function. Especially in models of cardiac ischemia and repercussion injury. These articles you are citing were based on basic science our lab was doing in the 1980s
Totally cool! Thank you for that work that you all did!!
Thank you for the in depth analysis – the level of detail is vey much appreciated.
I literally live for these videos! Thank you!!!
How do I get my “Thumbs up” vote to replicate itself? Another informative presentation. I like the way you repeat and review your ideas, makes it easier to retain the information.
A recent paper found that low levels of selenium are associated with worse outcomes for Covid-19 patients. Glutathione peroxidase is a selenium-dependent enzyme, so that’s another data point supporting your hypothesis. https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqaa095/5826147
Incredibly informative
Could you comment on this new report?
https://www.forbes.com/sites/carlieporterfield/2020/05/06/new-study-suggests-coronavirus-began-spreading-in-late-2019/#42d72be36996
If the virus has been circulating the globe since the end of last year unnoticed, what does it mean about the severity and the true infection fatality rate of SARS-Cov-2?
What do you think about use of L-carnitine to protect from Covid-19 or to improve recovery? There are many investigations that it reduces the oxidative stress response to AT-II. There is a good literature review on this topic https://zenodo.org/record/3740145
You might have missed it but important to note that VWF is one of the few proteins that’s is directly glycosylatied by the ABO enzyme. Presumably glycosylation increases it’s half-life and increasing it concentration in non-O people.
That’s important! Need to learn more. We need a hematologist.
These presentations make me want to become a doctor to help people. So amazing. Ty for clear & concise info during these uncertain times.
Just gotta say, I’m type o and I am an over bleeder. It’s a real pain.
Wondering if you could comment about
antiphospholipid antibody syndrome (APS) and the possible activation of Toll-like receptor 4 (TLR-4). Is that a competing hypothesis or does it compliment what you’ve been documenting? [h/t Dr. Mike Hansen’s 5/6 posting on YouTube (tu.be/KzKvIYwqQkE)]. Thank you for the excellent literature analysis and clear pedagogy.
Your analysis of Sars Cov2 was incredible…ace2·breakdown· oxy⬆·destruc epithelial· ⬆clotting· WoW…great lesson· alxenia Las Vegas📠🖨📻📺📬 5/6/20
2:51p
Thank you! So many snippets of this information are out there right now, but this is a great detail and explanation of how it all relates.
For a person with a sophomore level of college science courses, I am finding these astonishingly straightforward and memorable.
Some anticoagulants are also predicted to be inhibitors of the serine protease TMPRSS2 which mediates the entry of SARS-CoV-2 into the cell via ACE2. For example, argatroban was predicted to bind to TMPRSS2 with high affinity, according to a homology model analysis (https://chemrxiv.org/articles/Homology_Modeling_of_TMPRSS2_Yields_Candidate_Drugs_That_May_Inhibit_Entry_of_SARS-CoV-2_into_Human_Cells/12009582/1). The evidence is not very strong, but it may be worthwhile to further investigate.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203994/
So would antibodies from o donors be more beneficial than other antibodies?
Makes me wonder why it was advised to avoid aspirin in the early phase of the pandemic in France… There were doubts about NSAIDs – and the WHO said it before retracting their advice – but apart from its thrombosis prevention use I just read that acetylsalicylic acid could also protect from angiotensin II induced damages.
Hospital my lady works at is automatically giving admitted patients heparin and oxygen upon admission, and also vitamin c. The mortality rate in this hospital seems to be extremely low compared to NY
That’s good news. What hospital by the way?
Might bromelain, a proteolytic enzyme that both reduces clotting and helps break up clots that have already formed, be useful to someone outside a clinical environment to help reduce mortality from COVID19? Esp. taken with cinnamon that also thins blood.
Dr. Seheult, would using Acetyl L-Carnitine help raise blood levels of Nitrous Oxide. In turn, helping to regulate the oxidative stress???
Fascinating & it brings back to mind if it’s coming from bats (which are nocturnal) how much vitamin D do they have?
Also regarding pressure as bats hang upsidedown would patients have a better outcome of they are “suspended” upsidedown?
Also re blood clots (could vampire bats anticoagulation be used to aid blood clotting factors in covid 19 as this has the highest ability to prevent clotting) Just thinking outside the box?
Can’t help but wonder whether increasing the NO level in the bloodstream through oral supplements would interfere with the chain of events leading to thrombosis.
Dr Mikovits knows the truth. Either you need to wake up or your in on this as well Dr. You know staying in and wearing masks compromises the immune system. You also know hydroxichlorquine works. Dr Fauci did this.
so does this mean we should take a ‘glutathione reduced’ supplement, or is that a bad thing?
I think it can’t hurt!
Thank your the COVID-19 videos that you have been running. They have helped me to stay informed during these terrifying times. You did an earlier video on Ivermectin in vivo studies.
I would love to hear your contributors’ thoughts on some of the Ivermectin studies on patients which to a lay observer have shown a great deal of promise.
Thank you
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3580524
https://www.nbcmiami.com/news/local/local-doctor-tries-new-coronavirus-drug-treatment/2219465/
https://www.reddit.com/r/Coronavirus/comments/ge9jal/medical_report_from_doctor_in_peru_treating_covid/
I’ve had MI years ago, but I take Ramipril, Avastin, Asprin 75mg which may help me, & I’m blood group O, things are looking better?. Thew. Keep up the good work.
So does anyone who gets covid 19 have clotting going on in the body? But just not aware of it?
Thank you so much to all at Medcram, I’m an incoming medical student and this is teaching me so much about the field that I Hope I can apply one day to help patients in need.
I am very intrigued about the us of N-acetylcysteine (NAC) to prevent or to treat Covid-19 patients, since NAC is a preculsor of Glucathione, it could in theory help minimize the effect of of the ROS on the body as it is a very strong anti-oxydant, is a safe product , given that is mostly a food supplement and is inexpensive, what do you think?
He did discuss this in a previous video
Oh, nevermind. I’m trying to
Understand how blood clots
Happen. 😩😩
Memorizing the Coagulation Pathway should turn any Atheist into a Theist. We are fearfully and wonderfully made !
Excellent and professional as always. This explanation really does make a lot of sense.
Can we use Molecular Hydrogen to reduce Oxidative Stress ???
Dr. Seheult, have you seen signs that antiphospholipid syndrome (APS) may also be involved with COVID-19? A doctor here says that APS may also be plausible due to the similarities in symptoms (clots in both veins and arteries):
https://www.youtube.com/watch?v=KzKvIYwqQkE
If Clotting is happening in both arteries and veins isn’t this APS? Or CAPS antiphospholipid antibody syndrome
Amazing. Thank you
You’re welcome, thanks for your comment
Vitamin D and the endothelium: basic, translational and clinical research updates
1. In the absence of vitamin D and other antioxidants AGEs result in uncoupling of the NADH oxidase system in the endothelium and increased formation of reactive oxygen species (ROS). ….
11. The increased ROS in the endothelium stimulates the NFκB to dissociate from IkB and enter the endothelial cell nucleus and stimulates formation of inflammatory cytokines and chemokines, especially IL-6, IL-1B, MCP-1 and TNF-1α.
12. The NFκB also stimulates expression of cell adhesion markers such as E-selectin, VCAM-1 and ICAM-1 on the endothelial cells.
13. This stimulates the vWF and coagulation cascade and results in thrombus formation at the fatty streak and further perpetuation of the atherosclerosis process.
….
https://www.sciencedirect.com/science/article/pii/S2214762414000152
When going through the process at 10:00 on what vWF does, it made me think of people making slime videos in 2016 at the height of that trend. The slime or blood, is usually free flowing with a variable viscosity depending on the ingredients you used, but when they add the slime “activator” either borax, contact lenses solution, or liquid starch, the polymers start to bind to one another and you get your slime blob that sticks to itself, similar to clotted blood.
Nice explanation!! Dr. Roger Seheult. I have a doubt how is this SARS COV-2 virus replicating under oxidative stress and whether is it sustaining the oxidative stress inside the cell caused by it?
Another great lecture…This is exactly what I’ve seen with my recent young COVID + patient. All of the information you mentioned were evident and I can clearly see it through the presenting symptoms as well as the treatments and my patient’s responses. This is amazing. I am learning so much and I’m hopeful that through science and technology, we will defeat this virus.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3585561
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203994/
Positive correlation between CRP and vWF in hemodialysis patients with 25(OH) VitD <25 nmol/L
Abstract
Von Willebrand factor (vWF) is a glycoprotein with a crucial role in the formation of platelet thrombi, and ADAMTS13 is the main enzyme responsible for vWF cleavage. Both are important in the relationship between diabetic nephropathy, hypercoagulability, and cardiovascular disease. This study evaluated a potential relationship between vitamin D (vitD) levels, vWF, ADAMTS13 activity, and inflammation in diabetic patients on chronic hemodialysis (HD). Blood samples from 52 diabetic patients on chronic HD were obtained to determine vitD levels, vWF, and ADAMTS13 activity, and inflammatory markers. HD patients were grouped according to 25-hydroxyvitamin D [25(OH) VitD]<25 nmol/L (n=16) or >25 nmol/L (n=36). vWF antigen and vWF activity were elevated in both groups, with an average of 214.3±82.6% and 175.8±72.6%, respectively. Average ADAMTS13 activity was within the normal range in both groups. Blood samples from the vitD <25 nmol/L group showed a positive correlation between c-reactive protein (CRP) and vWF levels (P=0.023; r=0.564; 95% confidence interval=0.095-0.828), with a negative correlation between HbA1c and 25(OH) VitD (P=0.015; r=-0.337; 95% confidence interval=-0.337-0.19). Diabetic patients on chronic HD had elevated vWF levels and activity with no significant change in ADAMTS13 activity. The correlation between CRP and vWF levels in the 25(OH) VitD<25 nmol/L group suggests inflammatory-related endothelial dysfunction in these patients.
I’m not sure if it was mentioned, but was there an average time line for thrombosis to effect pt’s?
Thanks for making me brush off brain plaque and revisit biochem and cell bio lectures from 40 years ago! Nice job of hypothesis development… Next step, testing?
Zinc Cu Mn levels? Vitamin D levels?
See the indonesian study- of vitamina D, see belgium death and mortality rate
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3585561&download=yes
Watching you guys dance around the answer but never get there is beyond frustrating. Never thought my MCTD would save me instead of kill me but here we are 🤣
If you have type A blood group, better stay in Kerala, India.
How does this compare to other viruses that also cause clotting and/or hemorrhaging? I saw a paper from 2012 mention Cytomegalovirus, among others (“Review: Viral Infections and Mechanisms of Thrombosis and Bleeding” – Journal of Medical Virology 84:1680-1696). I’m curious because I died from a coronary clot last October that later Hematology testing couldn’t explain. (I’m better now.) And without knowing what caused it, I’m not sure what to do or avoid doing.
Dr. Roger Seheult, A big fan of your lectures. CF carriers with the CFTR gene mutation have higher prevalence of some comorbidities associated with COVID-19 complications. CF patients do have elevated VWF but I was unable to find any studies associating elevated VWF with the CFTR gene mutation. In addition, Hispanic CFTR gene mutation prevalence is much lower than Caucasion or European gene mutation which may explain the low complication rate of the Hispanic population. Could the CFTR gene mutation be playing a role in COVID-19 complications?
Please forgive my ignorance (I’m an engineer not a doctor). Maybe turbulent flow of blood (as opposed to more laminar flow) caused by reduced diameter pipes (thus higher speed to achieve same flow rate) may be a source of damage to the endothelium. But when damaged it triggers a repair process which would be ok if it was only localized damage however it is probably a lot more widespread in this disease. To me it seems likely that understanding nitric oxide pathway disruption is a big key to effective treatment because it is likely upstream of some other more serious problems.
Tremendous videos!
Dr. Seheult, thank you for another essential, brilliant explanation of the oxidative stress caused by SARS-CoV-2. I just wanted to bring to your attention this study from May 2019:
Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572624/
It seems these two dietary complements could be used in a prophylactic treatment to avoid both cytokine storm and blood clotting complications in COVID-19.
wow! thank you for sharing I will be eating onions and apples constantly
I thought you noted that the ADAMTS13 uses Zinc. Earlier videos mentioned Zinc, if allowed to enter cells through an ionophore, can limit virus replication. It seems increasing Zinc in one’s diet can help in prevention. Thanks so much for your clear and informative updates. We are learning together as it happens.
Use grounded airplanes as barometrically isolated Units for treatment of patients with respiratory problems, Instead of rapid manufacturing of Ventilators, the rapid manufacturing of external airlock chambers for these planes should not be an unobtainable goal.
https://www.clinicaltrialsarena.com/news/mgc-phase-ii-artemic-covid-19/ this trial sounds really interesting
We should look into Hydrogen Therapy to counter Oxidative stress.
Outstanding update tying things together! Thanks for all that you’ve shared with us.
Have you heard of the “Kawasaki” type syndrome that has been showing up in children, which is believed to be related to Covid-19 infection? Very interesting given the known connections between Kawasaki disease and oxidative stress (e.g., https://academic.oup.com/rheumatology/article/56/1/6/2631538)
Great video. I think this theory is highly possible and should be tested immediately.
Sorry I meant to say hello and thank you👋🙄👍
So do people with type O blood create a higher density of antibodies post covid that might be more potent than plasma taken from A, B AB?
At the disproportionate representation of blacks from community 18% to over 30% hospitalized. Was the breakdown of blood type noted among the black patients? And was their vitamin D3 status noted. Excessive melanin slows photosynthesis of active D. Perhaps dual cofactors in mortality. If D3 status normal in black A type blood is the outcome statistically better?
I had a professor – forensic anthropologist – who spent a class explaining how Malaria is the “cure” for Sickle Cell Anemia. The modifications to both when they come into contact basically restore the combination to a “normal” red blood cell. It was a very interesting lecture. I mention it because SARS-CoV-2 is responsive to malaria medications. [HCQ etc?]
Concern about ethnic vulnerability revolve around the African – Hispanic genome. What is the population with the largest rate of vulnerability to Sickle Cell Anemia ? African and Middle Eastern. Remember that a long period of Spanish history saw occupation by the Moors. Moors – from the middle east – interbred into the traditional Spanish population.
……. HCQ – Malaria – Sickle Cell Anemia – Anemia – Iron Disorder – Heme – SARS-CoV-2 ……
Additionally, it may be very useful to consider the work of Tu Youyou [ Nobel Prize 2015 ] and issues of Hemochromatosis.
Woohoo, 750K, BOOM!
Seems like prophylactic low dose Asprin for high risk individuals (hypertension, male, age, ethnicity, ABO type ) may be indicated
https://www.ncbi.nlm.nih.gov/pubmed/10973674
It seems you should also to consider Mentioning Blood Type B …. in your numbers group O and B has similar percentages about covid19 severity and ABO groups
So we find something to control VWF?
It would be nice if Von Wilibrand factor had a name with fewer syllables.
Have any hemophiliacs died from covid 19?
Look at 11,11 explains it very well.
Would you like a heavy dose of truth? – https://www.youtube.com/watch?v=_EYGULY0wMw&feature=youtu.be
Natural anticoagulants the would help
Ginger
Garlic
Onion
Cúrcuma
Red wine
Pomegranate
Omega 3
@Darcy Cuttlefish Nice👍
Just the foods I cannot eat ! see Food Chemical/Sensitivities . using your preferred search engine 🙂 Ginger of course was a late import to W Europe as it was a precious Spice. Curcumin ,too. so it affects a lot of European types. Trade History is useful!
Archaic Revival
In other words, fish curry and a bottle of red wine. Sounds good!
When Caucasians have less vWB factor then why Europe has the highest number of deaths per million ?
older population?
Too much air pollution
Love you! Thank you! 🙏
Vitamin C may be used as a super-oxide scavenger. This will break the sequence resulting in endothelial injury and thrombosis. IV Vit C should be used for severe cases. https://academic.oup.com/ajh/article/18/8/1111/136875
I know that a lot of this is just speculation at this point. But we really need to work on getting treatment protocols out there sooner rather than later. I’ve noticed that some doctors are reluctant to give patients anticoagulation therapy as it markedly increases their risk of uncontrolled bleeding.
If blood groups are significant, 85.5% Chile’s population are type O.
I’m sharing this paper, Low VWF levels in children and lack of association with bleeding in children undergoing tonsillectomy 1/2020 – As it bears to our recent discussion of VWF mediated coagulation, also since there’s lots of interest in children recently, owing to both: overall anomaly of low SARS CoV2 affliction in children and pediatric multi-system inflammatory syndrome. https://ashpublications.org/bloodadvances/article/4/1/100/430053/Low-VWF-levels-in-children-and-lack-of-association
Great video Doc! It would be interesting to know if people with blood type “0” have some protection against developing heart disease & stroke secondary to significantly less arterial plaque formation with subsequent thrombosis? Thanks again for these excellent videos………
Fantastic your incredible patho-physiological knowledge and All you knowledge in general and the use of it to the good for all human beings! Be blessed I don’t know if this was taught in your medical training but when I studied medicine [around 1965 ] I remember that we were thought that blood group O “bleeds” far easier than the other groups. So they should have less tendencies for all thrombotic processes.
In Italy heparin is used since the end of march 😑
Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment https://www.medrxiv.org/content/10.1101/2020.04.23.20076851v1
Ten times more likely to die of SARS2 if one has lack of VitD.
Could vitamin D deficiency also explain greater incidence in darker skinned people?
@Danielle M Sun light on darker skined people is slower to make VitD.
yes
Or just in colder climates it seems
I think so and Dr John Campbell thinks so too.
This is study in nature. That show the effect of blocking Adams 13 and vwf for acute kidney injury. By doing this Block you improve micro circulation and save the kidney.. https://www.nature.com/articles/s41598-019-51013-2
By the sme logic you can save the lungs and other organs from covid 19
Hello, Do you happen to have info on Ivermectin? I have heard some news but now alot about this Anti Parasitic drug.
@A G they should push the cheapest cure so all can have it .
There were some YouTube videos about it being used in Florida with positive results, but much like HCQ, it has to be used early for it to do any good, and it is cheap so no one cares about it. And YouTube took the videos down. Here is the link to the story about it https://www.nbcmiami.com/news/local/local-doctor-tries-new-coronavirus-drug-treatment/2219465/
Would aspirin help
Thank you for the detailed breakdown. To provide some context on the global mortality rate, please feel free to see my visualisation comparing the first 100 days of Covid-19 to every other major epidemic of the century: https://www.youtube.com/watch?v=fOa2rne4WJ4
You’re the only doctor whose handwriting I can understand.
Lol, wanna bet his ‘scripts aren’t quite as legible?
So true!
The issue here i think is that Afro Americans for the most part like most Americans are obese/fat they would rather push a burger and some fry food in their mouth than some veggies or whole grain.
like i keep telling people most of the foods you eat(over 90%) should come from three sources.
a tree,beneath the ground or the ocean.
Roger “von willebrand factor” Seheult
I’m being triggered to look into snake venoms that cause coagulation and to understand the relationships of krebbs cycle disruption in mitochondria vs what Covid-stars-2 is doing.
what is the standard treatment used in your hospital for covid-19 patients? Success rate?
He mentioned it a few videos ago
Hold on a moment.
The end point of replication in an infected cell is cell death: apoptosis mediated by mitochondria, or immune system intervention. The dead endothelial cell will spill all of its stored VWF into the blood. As virus particles infect more endothelial cells, they will die and VWF levels will rise.
You can’t prevent VWF levels from rising with an ACE blocker, you see? Or by otherwise fiddling with the oxidative stress cascade.
Reducing oxidative stress is itself a good thing to do, but it won’t affect VWF levels.
https://www.jci.org/articles/view/114733
This old article show the relation between elevated vwf and ARDS..
https://pubmed.ncbi.nlm.nih.gov/2098070 Vitamin D3 reduces Antiphospholipid syndrome.
Really fascinating. Also I notice the comments are very interesting too.
WOW ! Awesome talk ! Can’t wait to hear what we can do about the clotting 🌻
There is new paper about anticoagulation
https://www.eurekalert.org/pub_releases/2020-05/tmsh-btm050420.php The effect of anticoagulation had a more pronounced effect on ventilated patients–62.7 percent of intubated patients who were not treated with anticoagulants died, compared to 29.1 percent for intubated patients treated with anticoagulants.
Another great video. Thanks from Australia.
Just read vitamin D and K help prevent thrombosis
Yes, the right vitamin K helps. It has to be K2. The commercially available forms are MK-7 and MK-4 versions of vitamin K2. The natural forms of it can be found in natto (for MK-7) and in things like duck fat, goose liver, etc. for MK-4. I just take a supplement that has both of them since I can no longer find natto at my local store.
I have an unknown clotting disorder that multiple hematologists cannot diagnose despite testing. I’ve had clots get stuck in my heart that required a bypass when I was 23 and stent placement ten years later. So far they just have me permanently on Coumadin and Effient and a baby asprin everyday despite the bleed risks and they are just hoping it doesn’t happen again. Before this virus came my cardiologist recommended I go to clevland clinic or Mayo and see if they can figure out whats wrong. I’m terrified of this virus now that I know it kills with clots and causes clotting, and they’re making me go back to work soon. One thing I am going to do if I survive this is get my vWF and D Dimer checked asap just to see if its relevant.
Thank you for these videos, they are wonderful
Hi, I just read an interesting article about the covid unit in Parkland Hospital in Dallas. They stated that they are seeing a 80 percent success rate with there intubated patients, it would be interesting to know what protocols they are using
@Michelle Shewaga agreed. Maybe it’s the negative pressure room that’s making the difference. Not all hospitals have the option or are setup for this option and parkland has a large one that can hold more patients. They converted a whole floor dedicated for it. so my guess is that might be a crucial distinctive advantage of this particular hospital.
Yes, I read that as well, but it would be nice if someone could reach out to find out what they are doing differently as to patient care. Heparin therapy?
Only detail I could find is that they are using a large negative pressure room. Havent heard anything on the medication protocol.
Excellent info. The part I don’t understand or don’t know is how the release of VWF by the endothelial cells triggers the production of antiphospholipid anti-bodies. Is there a possibility that research in this area may give some future relief to Lupus patients with APS?
Can you say baby aspirin daily is partially protective boys and girls?
@A G I take baby aspirin to keep clots from forming, and feel that any advantage that might have keeping blood cells from micro thrombosis under any stressor is an advantage.
Against platelet clots, yes.
Thank you for your videos, I really like the visual aids in that I’m not in the medical profession so all the terms are Greek to me, I probably should have been in the medical profession. I think I started watching at least at episode 32 if not before, it was my favorite in that you did because you visually showed what hydroxychloroquine and zinc did to shut down the virus making copies. My second favorite was update 59 where you said what you take supplement wise to be safe I was so happy to find out that Quercetin was an ionophore like hydroxychloroquine is an ionophore which both open the door for zinc to go in and stop the virus from making copies. Quercetin is in a lot of foods,but I still bought Quercetin,zinc,NAC and copper. My husband and I work in the retail sector of essential workers. We also do what you do in changing out of clothes before entering the house ,showering and laundry for our clothes right away,we also wear a mask that is only removed when outside while taking our breaks. Thank you a bunch you have a lot of great videos.
There’s that zinc again .
Dang zinc and copper like the janitor and maintenence crew . Never seen , never congratulated , but sure do miss those guys when they call in for a vacation .
I noticed that too. But shhh.
Yes, that pesky zinc again. 🙂
There is another route you are missing here. I tried to contact you via email. I would like to get you to collaborate with other Drs on YT with whom you are often crossing paths.
Just today on the peak of my stress (had cardiac chest pain in 28, nice) considered using nitrates and thought: these are vasodilatators/angioprotectors why not use them?
At least a bit happy to be a white [just considering the study, no racism] blood 0 type guy (ofc better outcomes in women:).
Dear MedCram is it possible to theoretically predict effect of well known NO boosters like AAKG or Citruline Malate on Covid19 potential outcome?
Quick reference to this article: https://www.sciencedirect.com/science/article/abs/pii/S0022214398901573
would it be wise to give a patient prednisone with blood thinner? im not a doctor im just thinking .
Have you noted this study about the positive effects of smoking in reducing the severity of the virus (up to 6 times less hospitalizations): https://www.economist.com/science-and-technology/2020/05/02/smokers-seem-less-likely-than-non-smokers-to-fall-ill-with-covid-19 it seems to be because nicotine competes in binding to ACE2.
Amazing and the blood-plot keeps thickening…
KEEP UP UR FANTASTIC WORK PLEASE AND THANKS!!!
@Journey of the Dawn Treader 😀
Love your profile pic and comment 🌅
Please comment on L.A. Times article on Los Alamos National Laboratory study that found that SARS-CoV-2 in the United States is a new more contagious strain (D614G), see: https://www.latimes.com/california/story/2020-05-05/mutant-coronavirus-has-emerged-more-contagious-than-original Thank you.
Do they deliberately chose the longest words they can think of to describe medical terms and chemical interactions. Thanks for the information I don’t pretend to understand it all but have learned so much.
Oh mother of pearl , we need a double blind studies of the ‘soulvana’ ad .
I would like to know why some people they get the virus and it seems just like a normal flu symptoms fever dry mouth headache body aches thanks
Their immune system fights off the virus early on before it can spread and take out too many ACE2
Blood type starts 14:00.
Consistently, many studies have found that increased oxidative damage in cells is associated with aging.
Those p/million figures would dramatically change if TESTING were a priority worldwide. EVERYONE got tested or at least a huge representative sample. But once again Profit over People rules the day!
I don’t understand a lot of what this Dr is saying but it is heartening to hear an apparently very bright and well intentioned Dr trying to solve this pandemic. Thanks Dr
If cats and dogs are found to have SARS2, why not rabbits >>> if they produce anti bodies can’t we harvest the serum in short order to use as a therapy without having to bleed our CoViD19 human survivors?
It alsomight help us in determining effective treatments to review receptor molecular (dis)similarities and determine why it is only weakly presented zoonotically vs humans.
latinos are largely 0+ I guess that explains why currently Peru and Canada differ so much in mortality rate despite more or less similar number of confirmed cases, despite the obvious difference in their health care systems?
Shouldnt the treatment simply be an Aspirin?
it only works against platelets. It is a blood thinner, not an anticoagulant. It might be a good preventative to do at home if you have very mild case.
The oxidative damage theory of aging.
Thank you doctor, I’m always eagerly waiting for a new video from you and especially since this new superoxide investigation has begun! I can’t wait to get to the bottom of this and I hope your hypothesis is correct and you get all sorts of awards that you very much deserve 😀
Noticing a correlation between public healthcare and deaths per million.
eu is not just germany, ita, or spain. dig deeper.
ADAMTS13 levels(high) is a predictor of Type 2 Diabetes and a consistent finding. Considering Diabetics have a significant increased morbidity this hypothesis may not be correct. Could be elevated because of elevated VWF as well but there’s also theories that elevated ADAMTS13 up-regulates Vascular Endothelial Growth Factor. VEGF has already been shown in high levels in patients and contributes to induction of vascular permeability in COVID. Granted, in the COVID version of ARDS maybe VEGF may actually be protective. Nicotine, which also upregulates VEGF has been shown to treat women with preeclampsia. A topic the doctor previously discussed. So hypothetically the protective effect of nicotine studies seem to be showing could be explained by VEGF. Since maybe the COVID version of ARDS is, in fact different, NO may be the key since VGEF is increased. Concurrently, progesterone has also shown to increase VGEF levels interestingly. But still doesn’t explain the co-morbidities that also have increased VGEF.
Lay person here. Can AT1,7 be increased some other way than through the natural process? Might that cut it off at the pass, so to speak?
Should we start therapeutic doses of Heparin, such as Heparin drip to patients diagnosed with Cvid 19 going to the ICU with high Ddimers? How long to keep it on it’s also the question. Mount Sinai hospital seems to be doing it
Dr Mikovits. Look it up.
Heparins are standard for high dd regardless of the infection.
Question, if ACE1 ultimately gets converted to ACE2, then how do ACE inhibitors uptick ACE2?
@Gerald Sahd I can’t answer that one, it seems intuitive to me that we might expect the opposite. i don’t know if anyone knows. I think at the moment, it’s just an observation.
@Tom Terific Good clarification – so what is the thinking that ACE inhibitors uptick ACE2… thanks
There is no “ACE1.” There’s just ACE and ACE 2, and ACE does not get turned into ACE2. ACE 2 likely got its name because it was the second “Angiotensin converting Enzyme” that was described. A lot of naming in biology is like that, But the two are different enzymes, encoded by different genes.
Ace and ace 2 are completely different.
im Ab+ so happy
Are you using Glutathione, SOD and IV Vitamin C in the clinic? The Chinese were using between 24 to 50 Grams IV C plus heparin in the hospitals.
Like your earlier talks, very interesting and relevant ideas. However, I’m skeptical about one link in the long chain of influences, in your model, viz., the lowering of ACE2 leading to significant reduction in ATI. The basis of my skepticism is that ACE2 is an enzyme, so that even if the number of copies knocked out by viruses were a big fraction of the total, there would still be lots of enzyme activity in the system—-each enzyme molecule can catalyze hundreds or thousands of reactions. So, please convince us that this link in your logical chain is sound.
@Tom Terific what data? from where? I thought science is about experiment, but you can’t do those on humans easilly, so essentially we don’t have science in this case. ie when we really need it.
He’s not claiming his chain is precisely how it happens–it’s a working hypothesis–one that can and should be tested. The convincing should come, not by argument, but by data.
Doc, could Insulin Resistance and/or elevated Blood Glucose levels be leading to increased Von Willebrand Factor a co-factor in SarsCov2 death or complications? I am willing to even bet that all the patients that don’t have T2 Diabetes have Pre-Diabetes or elevated Blood Glucose or Higher HBA1C levels and do not know it because they haven’t been tested for that in the past. Could also fasting or limited or eliminating carbs during the treatment period help with reduction of inflammation or boost the immune system?
https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2002.01024.x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543747/
ksawa70 would make sense as to why diabetes patients have greater Covid issues. Thanks for sharing.
I’m curious about the ethnic impact. I just read that some 90% of cases in San Francisco are of Latin ethnicity. Brown county WI and Hamilton county NE cases are heavily hispanic, but it has been blamed on the close quarters of meat packing houses. Is that true in SF?
I’ve heard the Thalassemia trait played a part in the high death rate of Italians.
There is speculation that vitamin D deficiency might be one factor in worse outcomes. It’s just a hypothesis but it seems reasonable to look into, especially since it would be so easy and safe to fix with sunshine and supplementation.
I wonder if people with type O blood have statistically significant reduced incidents of cardiac issues, through the machinism of less von Willenbrand Factors and less coagulations.
Going to go down the Vitamin D deficiency idea again. Dr presents research showing decreased ADAMTS13 contributes to coagulation. Here is some research showing that Vitamin D “up-regulated ADAMST13 expression” in an in-vitro study.
https://pubmed.ncbi.nlm.nih.gov/28853522/
Here is another study looking at Vit D and vWF and ADAMTS13.
https://pubmed.ncbi.nlm.nih.gov/28029003/
@Lee Fields you mayo check yours father serum levels of vitamin D if he’s under 30ng/ml he maybe nerd increase dosis. 30 -50 ng/ml levels is the ideal.
Many thanks. My father is diabetic and I started him on Vitamin D some time ago. Considering he barely gets out now during lockdown. Its great to see the dots getting connected here in more detail.
Send me data of vitamin D, and covid [email protected]
Fascinating thank you!
USA is mostly in lock down so low outbreak States in Mid West, etc, are not only containing the infection, but skewing the general statistics.
Stay safe
Does NO indicator strips provide a good test for NO levels in humans?
Another excellent upload. Thank you again for all the research and effort, and for sharing it with us all.
I would like to quickly touch the topic of higher mortality in patients with darker skin color. I got this hypothesis from another doctor on his channel. He is proposing (and is quite surprised that no one else is looking into this) that Vitamin D might be playing a role in this, or rather Vitamin D deficiency, as people of darker skin color apparently are slower to produce vitamin D, especially if they migrate north in countries with fewer sunny days.
And Vitamin D plays a major role in our Immune system.
Dr. Seheult if you get to see this comment might be worth looking into Vitamin D deficiency as well, might help in connecting the dots further.
In any case, great work, keep it coming 🙂
“When controlling for age, sex, and comorbidity, Vitamin D status is strongly associated with COVID-19 mortality outcome of cases.” according to this study: https://papers.ssrn.com/sol3/[email protected] – Medical Lectures Explained CLEARLY
@MedCram – Medical Lectures Explained CLEARLY
You certainly have 🙂 I must say I particularly enjoyed videos about immunity and cellular microbiology, learned a lot. I like to know how things work, although I am not in medical profession I find these kind of video very interesting. Also, I am actually fighting against viruses, only different kind, digital viruses.
Something a bit off-topic for this video, but you might find it interesting. Previously there was a lot of talk about Covid-19 death rates but as we all know it is very hard to say at this point as we are missing a lot of data points, numbers of infected people and people that died from it are mostly underestimated. However, one piece of statistical data can tell us more. Thankfully UK is quite good in collecting and publishing statistical data. So this link for UK’s Office for National Statistics can help us see a bit more about Covid-19 impact on the mortality rate this year compared to the 5 year average. Nice charts and all 🙂 To bad other countries are not doing the same 🙁 as this piece of data might be the only valid piece of data we have as to the exact impact of Covid-19. You might be surprised to see how big the jump in mortality rate actually is in compared to the 5 year average.
https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsregisteredweeklyinenglandandwalesprovisional/weekending24april2020
Got this from the other channel as well. Only reason I am not naming the other channel is out of respect towards the work you do and I do not wish to advertise it here.
Hope you find this useful as well.
Looking forward to seeing more videos on your hypothesis 🙂
I see it! We’ve covered it before but not I this light (pun intended)
News: Covid 19 coronavirus – Chinese researcher Dr Bing Liu killed in murder-suicide in US
@Cheryl Pedinoff but the suicide took 5 shots in the head, and he knew the “killer” his Chinese friend. any idea?
Very sad
The big “O” who knew. VWF, now we are getting somewhere.
Careful, if you mention “the big ‘O'” the wrong way there will a run on KY Jelly.
Rh factor? Does the negative or positive also make a difference?
AB- for example has best platelets used post op in patients…
I don’t think so. The Rh System is a separate group of antigens.
What about israel cure , can you explain ?
Thank you for talking about BLOOD TYPES. To my fellow Type A’s – garlic, garlic, garlic helps us fight infections. The Blood Type Diet has YES and NO foods for each blood type. 🙂
Here is the Blood Type Diet overview. Ever tried putting diesel fuel in an “unleaded vehicle”? Well eating the wrong foods for your blood type works the same way. The “right” foods are digested easily. The “wrong” foods create lectins (proteins) that clog up your body. It’s easy to swap out the foods that are “bad” for you! For Type A’s (like me) oranges are bad, but grapefruit and pineapple are good! A few major changes may be necessary — so I suggest people try it for a week (ideally 2 weeks) and see how you feel. I literally dropped a pants size in a week! No extra exercise, just eating right for my blood type! I have permission to teach and answer questions about The Blood Type Diet. The science is Dr. D’Adamo’s. I just explain it in plain English 🙂
@girlgeniusNYC thanks
Throw me some articles . I’ve never heard of this subject . I’m very intrigued.
I can direct you here (site listed below). I tried the Blood Type Diet and it worked for me. It has worked for many people. Some people hate it. I encourage you to do your own research https://www.dadamo.com
Can you please link the peer reviewed source for that information? I would like to read the studies.
Sir, thanks for another great explanation! Do you think that might be a correlation between VWF and vitamin D? Check out this article: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0320-9
@Thomas Müller Great link, many thanks.
@Jason Mateos Yes, that’s why we need to tell people to expose themselves to the sun
Thomas Müller Nice connection, very nice! All the research I’m seeing about minimizing covid symptoms keeps pointing back to vitamin D. This is another nail in the coffin (of covid 19).
Thomas Müller Very interesting article… thanks for sharing!
Very interesting lecture. Thank you. Perhaps prophylactic consumption of an anti thrombotic agent, enter natto (nattokinase) would protect those who ostensibly do not require hospitalization because they present with light or moderate covid symptoms. Sadly, these same patients can sometimes appear in the e.r. after they have supposedly recovered . They can suffer from strokes, deep vein thrombosis, etc. In Japan, natto is consumed at breakfast everyday. It’s theorized natto protects the Japanese population from heart disease, etc.
@Strait upno kicker fermented soybeans. Super healthy.
What’s natto?
I’m so into natto – truly a super good ! The only thing is, I think , natto had a high level of vitamin K , which increases clotting – I’m not sure if natto has enough to cause that … I mean looking at the Japanese it does not seem so.
It would be very interesting to see what the mortality rate from COVID-19 is among people that have Von Willebrand’s disease – if there even is a large enough cohort to test
@FlameRedCat Can you share you age and gender?
I have type 1 VWD (the mildest form) & I’m also blood type O Rh+. I didn’t have the chance to be tested but I’m fairly sure I had COVID-19 earlier this year. It took 2 months to recover fully (although the first 10 days were the worst part) but I have recovered, despite the fact that I have permanently lost the use of 40% of my lungs (prior to infection). I’m so lucky!
I bet their mortality is low !
17:43 MulTimeric analysis, as in vWF mulTimers.
That’s a cliff hanger. Hang in there.
Very good video.
IN Romania they are treating with a new protocol that consist also in anticoagulats and ozone therapy
@health proff there have been reports in China, Italy and Spain – in that last occurrence the case of a patient no longer needing ventilation after ozonification of the blood through auto transfusion, don’t know if anything proper has been published, all I’ve seen were newspaper articles. Alas it appears there are lots of snake oil dealers around the ozone. Hard to imagine it’d reduce oxydative stress.
Not surprised it takes your oxygen so ozone is needed
Used to kill bacteria and fungi be creating an aerobic environment. Not FDA approved. Has it been working?
I would like to know more about this.
Ozone ?? I am interested in knowing if they cure infection or just relief for symptoms
I would like to know how the RH factor plays a role in this. I am RH Negative and would love to know how it affects us.
Also interesting
https://www.google.com/amp/s/www.livescience.com/amp/why-covid-19-coronavirus-deadly-for-some-people.html
Go to section blood type
Found it
https://www.medrxiv.org/content/10.1101/2020.04.08.20058073v1
We used observational healthcare data on 1559 individuals tested for SARS-CoV-2 (682 COV+) with known blood type in the New York Presbyterian (NYP) hospital system to assess the association between ABO+Rh blood type and SARS-CoV-2 infection status, intubation, and death. We found a higher proportion of blood group A and a lower proportion of blood group O among COV+ patients compared to COV-, though in both cases the result is significant only in Rh positive blood types. We show that the effect of blood type is not explained by risk factors we considered (age, sex, hypertension, diabetes mellitus, overweight status, and chronic cardiovascular and lung disorders).
I googled blood type covid-19 and found an article, thats all i remember because i got happy since im o+
A T same I’m O-
Its O+ who bebefits according to studies i read on thias.
Thank you! 👍💖
I noticed this morning that Israel has isolated a SARS-COV 2 antibody for a vaccine!
What I need to know is . They are talking about different strains . How does that play with vaccine
Thank you
Melatonin + Vitamin C to fight Covid-19!
1. Melatonin has a potent anti-inflammatory action, especially in the lungs. Melatonin has shown the ability to break the ROS/inflammation vicious cycle. Inflammation/ROS is elevated in Covid-19.
2. Melatonin is a potent scavenger of many radicals, including reactive oxygen species(ROS), reactive nitrogen species(RNS), hydroxyl radicals, hydrogen peroxide and peroxynitrite. These are known bad players in Covid-19.
3. Melatonin is a protector of major organs, including heart, lungs, liver, kidneys, skin and brain that are all now known to be injured or damaged by Covid-19. Melatonin or its metabolites can cross the blood-brain barrier(BBB).
4. Melatonin upregulates gene expression of the body’s potent antioxidants such as superoxide dismutase(SOD), glutathione peroxidase(GPx), catalase, and glucose-6-phosphate dehydrogenase (G6PD). These can all go a long way in limiting and improving the damage induced by Covid-19. Vitamin C is synergistic with melatonin in terms of improved total antioxidant status and inhibition of inflammation.
5. Melatonin protects the mitochondria function through its potent antioxidant activities and increases the efficacy of mitochondrial electron transport chain and reduces electron leakage. Through its potent antioxidative actions, it prevents tissue damage and blocks transcriptional factors of proinflammatory cytokines. These are all crucial points relating to Covid-19 and the damage it is known to cause.
6. Melatonin reduces free radical damage to DNA. Melatonin receptors are found throughout the body suggesting that the body has many uses for it. Melatonin may also allow lower doses of Hydroxychloroquine to be effective.
7. Melatonin is an inhibitor of NADPH Oxidase, which becomes significantly elevated in Covid-19 patients and can do very significant damage to the epithelium via elevated superoxide levels if left unchecked as outlined in the MedCram video series.
8. Melatonin and its metabolites are neuroprotectant and can cross the BBB, which is vital since Covid-19 is known to enter the brain and do damage.
9. Melatonin is an endothelium protectant, which is important because Covid-19 is now known to damage the endothelium, which is a significant part of a cascade of damage that Covid-19 leaves in its wake.
10. Melatonin exerts a direct antioxidant effect on tissues/organs and antiapoptotic effects on cells. Melatonin inhibits neutrophil activation and reduces the damage they cause to endothelial cells, which is thought to occur in Covid-19 patients.
11. Melatonin can improve sleep, which can be crucial in keeping the immune system in good operating order.
12. Melatonin increases very significantly from birth to around age 4 to 7 years (a specific age group that seems very resistant to Covid-19) and then declines slightly until puberty, at which point its production and secretion by the pineal gland reduces sharply by age 60/65.
From that point on, melatonin levels are negligible. This 65+ age group with the lowest melatonin levels is also the group that seems to be most susceptible to the adverse health effects of Covid-19.
Obviously, with age, in general, comes multiple health issues that can account for part of the problem. Still, you can see where a lack of melatonin could be an additional factor that can be resolved through appropriate supplementation of melatonin. Add in the fact that many pre-existing conditions and diseases have shown to lower native melatonin levels in this already higher risk group and melatonin starts to take on even more significance for this high risk group.
Melatonin Graph
13. Melatonin in bats is approximately four times that found in humans at its highest levels for each. Bats are believed to be carriers of SARS CoV-2, yet bats seem unaffected by the virus. Is melatonin a contributing factor for this feature of bats? Melatonin may be causing the more controlled innate immune response seen in bats, but this is as yet not proven that melatonin is the reason for this process in bats.
14. Melatonin in women is generally at significantly higher levels than men. In the study that Dr. Seheult refers to in one of his videos, he mentions that out of the 100% of patients admitted to the hospital for Covid-19, 60% were men, and 40% were women. Could the significant difference in melatonin levels be a contributing factor to this phenomenon? Another possible contributing factor is that women are thought to have more ACE-2 than men. The virus can exhaust or destroy ACE-2 once it binds or docks to it to manufacture more viruses. Since melatonin has shown that it can increase ACE-2, is the higher melatonin in women the reason that they are thought to have more ACE-2?
15. Melatonin is released in the blood and can penetrate all body tissues, which suggests it can probably get to every place that the virus does within the body. Melatonin and Catalase reduce the cytotoxicity of Neutrophils in a dose dependent manner and this is important because this is a potential reason for the Endothelial damage that is likely occurring in Covid-19 patients. Melatonin upregulates gene expression of Catalase.
16. Melatonin can down-regulate the innate immunity overreaction response to SARS CoV-2, limiting the potential for the cytokine storm that has been seen in Covid-19 patients and has resulted in death. While doing this, it is promoting the adaptive immune response, which can aid in the production of antibodies to SARS CoV-2.
17. Melatonin at higher dosing, such as used by Dr. Neel, can downregulate NLRP3 inflammasome activation to help protect the lungs and other organs. The antioxidant and antiinflammatory effects of melatonin can be enhanced by higher-dose vitamin C, just as Dr. Neel is using in his Covid-19 patients. Quercetin is also likely to have synergy with melatonin in terms of being anti-inflammatory. On the other hand, high dose vitamin D (4,300 IU+/day) reduces melatonin production. Bats have little vitamin D. Vitamin C is useful and synergistic with melatonin, but pales in comparison to the potential broad ranging utility of melatonin in Covid-19 patients.
18. Melatonin acts to ameliorate atherosclerosis through inflammation reduction, radical scavenging and mitophagy activation. Covid-19 may rapidly add to existing atherosclerosis and contribute to these vascular complications seen in patients with Covid-19. Melatonin reduces vascular permeability.
19. Melatonin has been shown to increase ACE2, and this is important because the virus pretty much exhausts or destroys ACE2 as its primary means of virus replication and this is an early point in the infection process that ultimately results in further damage to the cardiovascular system and other parts of the body.
20. Melatonin + vitamin C, through their potent antioxidant and anti-inflammatory qualities, ameliorates the very significant levels of ROS that damage the lungs and contribute to pneumonia as well as damage the endothelial cells. If you can eliminate pneumonia and the cytokine storm, then a ventilator will never be needed. Those three things have shown themselves to be three main things associated with death in Covid-19. Ameliorating damage to endothelial cells can go a long way in keeping the vascular system operating well and reduce the chance for blood clots.
21. Melatonin, through its anticoagulation effects, can reduce thrombosis. Covid-19 is showing the ability to induce thrombosis that can lead to stroke and heart attack in patients with Covid-19. Melatonin’s potent antioxidant actions reduce oxidative stress to reduce the potential for thrombosis. Melatonin also reduces edema that can be caused by blood clotting.Melatonin reduces Von Willebrand Factor in C-19.
22. Melatonin lowers C-Reactive Protein (CRP), which is a marker for inflammation which is elevated in the presence of inflammation and at elevated levels in Covid-19 patients. CRP is a known target in many diseases in which CRP is significantly elevated, including Covid-19. Higher levels of CRP are associated with non-survivors in Wuhan, China.
23. Melatonin + vitamin C, both lower Interleukin-6 (IL-6) levels. IL-6 is a cytokine and another inflammatory mediator that is at significantly elevated levels in Covid-19 patients and is known to be a significant contributing factor to the “cytokine storm.” Melatonin also inhibits the chemokine IL-8, an upstream inflammatory mediator which draws other inflammatory cytokines and other inflammatory mediators into the fray of Covid-19 so lowering IL-8 is important in controlling inflammation induced by Covid-19. Melatonin also lowers the inflammatory cytokine IL-17 which is elevated in Covid-19.
24. Melatonin is useful before, during and after a stroke. This is important because of the increased reporting of strokes and heart attacks caused by Covid-19 disease. Melatonin is heart protective. Melatonin lowers homocysteine and increase nitric oxide. It is good to keep in mind that multiple disease states can diminish native melatonin levels and if you combine that, with the fact that the elderly are already at the very low end of the human melatonin scale, the importance of melatonin starts to become clearer as people with certain pre-existing health conditions are more likely to succumb to the disease and melatonin may help to level the playing field and improve patient outcome and mortality.
25. Melatonin is also available in cream and suppository forms, which may make it an option for patients already on a ventilator. If you are a senior citizen on a ventilator and aware of the survival rate for same, would you want melatonin cream applied or a melatonin suppository or possibly both? Covid-19 increases the cytokine IL-1b which is known to suppress melatonin production. If this is the case, the little melatonin that senior citizen patients have is likely to be depleted even further.
@health proff No, I don’t sell supplements. Melatonin and vitamin C are two of the least expensive supplements and vitamin C is currently very hard to come by. I think there are important reasons why the body makes melatonin and science is showing us some of those reasons with increasing numbers of studies everyday. Dr. Seheult is highlighting, to the best of his ability, what SARS CoV-2 is doing once it enters the body and starts its cascade of damage. I am trying to highlight that melatonin works through some of these same pathways that he is mentioning and can either prevent or ameliorate that damage to a much more manageable level. Everything I have listed above, I have study links to illustrate, but on this format, it will limit what I can post to the amount I have posted, so I can not include those references. I would rather be able to send all of the information I have gathered to him, but without an email address, that is not possible. His friend Kyle, who I sent some of that information to said that they were to small of a group to be able to review it and said that I should post it here in the comments section below the videos, so that is what I am doing. In any case, melatonin is showing itself to be a very impressive molecule! Dr. Neel is having very good success using it in his Covid-19 patients and that is another reason I am writing so much about it. Not much money in melatonin, but if drug companies could somehow patent it and charge as they do for other drugs, many pharmaceutical companies would love to have it in their lineup! Fortunately, here in the US it is an inexpensive over the counter sleep aid. Here is a link to a biomedical scientist who agrees about the use of melatonin for patients with Covid-19 :
https://devinenews.com/biomed-scientist-believes-melatonin-can-help-fight-covid-and-post-infection-complications/
https://www.tandfonline.com/doi/full/10.1080/08830185.2020.1756284?scroll=top&needAccess=true
Do you sell supplements
Dr Palade’s name is pronounced Pa la day, he was an electron microscopist and described many organelles eventually winning a Nobel Prize. I got to hear him as a student at Haverford College over 60 years ago.
One comment from a blood banker, A,B, AB, and O are blood groups as the authors stated correctly in the papers you discussed. The only blood type in common usage is Rh. Minor issues, keep up your excellent work.
And Weibel is pronounced Why bul–that’s Ewald Weibel, who among his many contributions, wrote one of the best monographs on respiratory physiology, “The pathway for oxygen.”
Thank you. Group and type. Got it.
Doctor could you please do a video on link between eczema, asthma, oxidative stress, and clots. Could you please let me know how i can avoid clots and its complications? Thanks much. I’m stressed with all the new information about covid because it shed light on my existing conditions.
I remember seing that Chinese study on blood groups some 2 months ago. Does anyone know, if there have been more similar studies, conducted in other parts of the world?
I agree this could shed some light
I am on Eliquis for a clot in my leg. The clot is right at my hip joint so I will be on drugs forever. So this may benefit me if I get covid ?
Vascular surgeon. He said that a stent could have been installed if it wasn’t so close to the joint. But when I flex the joint it would collapse the stent. He also said that my body was doing a good job finding a return path for the blood. My leg still swells sometimes.
How did you know you had a clot in your hip bone ? Did you have any symtoms ? Will your medication eventually dissolve it ? I watched some you tube vids about how doctor’s now can use this vacum like device to go into the veins and suck the clots right out ! I watched a woman go into the hospital in a wheelchair from so much blood clot pain and they did this while she was awake and an hour later clot free ! It was sooo amazing ! I hope you can look into this – it would be sooo great if you could somehow get rid of that clot. Blessings and prayers to you 🌅BTW – what is your blood type ? I’m B positive and I’ve heard B gets the most clots 😭 Take care 🌅
How did you find out about the clot ?
Thnx doc ! Really appreciate these videos! My question; are patients who administer ACE inhibitors or ARB -more at risk than patients with the underlying condition for which these medication are prescribed and are not taking said treatment?
Would sickle cell trait make any difference?
So, support your endothelial cells by eating whole foods, especially those that promote NO, and mild exercise which also supports NO production and endothelial cells. Side effects are reversing T2D, etc. Why is this simple message, to stay away from processed and fast foods, not part of the CDC messaging? Rhetorical question, as it will never happen. Great video. Thanks.
Same reason why doctors didn’t start telling us to stop smoking until after they broke the habit.
They are too busy fooling with cholesterol and cholesterol lowering.
I enjoy your erudite presentations immensely. A couple corrections Dr Palade
I just ordered Superoxide Dismutase to add to my supplements. Did I waste any money?
I don’t know , but ur very cute . Nice pic 🌅
Thank you for your informative videos. You are a treasure!
Hands up Blood group A CV19 survivors. I had my first symptoms on 15th March. 99% better with only occupational breathlessness now. Not hospitalised. Ride it out at home, moderate verging on severe case. UK. Thank you for the detailed analysis and hypothesis. I find it all fascinating. If disturbing. 😐 UK have a high representation of black and Asian cases of severe symptoms. Makes my blood run cold as Africa just is beginning their fight with this.
A G and they don’t lack the vitamin D like blacks outside of the continent and Caribbean countries so they are doing better. Plus they are already fighting malaria so they are resistant to covid19
The reports from certain western African countries has been surprisingly good. The use of the BCG vaccine is much more common there and seems to offer some protection. Also, they tend to give HCQ to their patients very early in the course of the disease to keep them from needing to go to the hospital, and that seems to be working.
On the sort of positive, average life expectancy in africa is 69, most covid death is over 65.
You are truly an 😇. Thank you for bringing this important information to the lay person as well as the medical community.🙏
Thanks very much for this information. Now I can converse with my wife (surgical tech) and daughter (veterinarian) for as long as 30 seconds on some days.
Here you go ☺️ https://www.cdc.gov/media/releases/2020/s0422-covid-19-cats-NYC.html
you would go beyond 30 if this had anything to do with either surgery or veterinary
There is a common Feline Corona Virus, that should give you another 30 seconds conversation with your daughter 😉
Black people living in the same latitude produce less Vitamin D than Kaukasians ! So the standard D-level in black population of USA is far too low. D-Level should be min. 30 (better 40) ng/ml
Everyone should be taking extra Vitamin D !
True.
I’ll keep taking 1000 units of High-Gamma Vitamin E to prevent clotting.
@Stanny1 a lose dose aspirin would not be too much. It definitely thins the blood.
Might be Too Much? Aspirin has some side effects and some experts say it doesn’t much.
I’m currently taking natural gamma E myself. And I take natural (annatto) delta and gamma tocotrienols as well.
That is a good point. How about low dose Aspirin and Vitamine E
Another superb lecture, thanks. Would be nice to listen about NO-based medicine effects on Covid-19.
Great video 👏🏾👏🏾
I found the info about type O blood is interesting. I am a 58 year old type O blood person. My platelet count has been always in the lower end of normal. I am somewhat easily bruised and bleeding last longer. I always joke to my husband about this trait. I told him to remind any surgeon who may operate on me. Luckily, so far so good with all the blood work and health. I guess thrombosis may not be as bad as bleeding for me.
I really enjoy your videos. I have been sharing them on FaceBook. Lately YouTube has removed the ability for me to share your videos on FaceBook. I know how to “copy and paste” so I’ve been sharing your videos anyway. Why, on Earth, Would YouTube do this??
they do it all over lately … but they leave a lot of “Alien Race is our main ancestors junk-science” up there … out there … for all to see” yyy …..
Then following this logic, what do you think of possibly trying transfusion of platelets Loaded With Recombinant ADAMTS13 at the point of increased d-dimer. Thank you for everything you do!
Link?
Interesting connection of the dots. I looked up the verboten word HCQ plus vWB factor. Guess what Google popped up? NIH article explaining that lupus patients have high vWB factor which is treated with HCQ.
@Tamara Spillis All I know is I am special since I am AB+ 😂
Yup
@Urgelt I agree with your assessment of Gain in Function. Definitely suspicious.
You didn’t! The word that should not be mentioned. How about neutralizing the superoxide with IV Vitamin C (another verboten word). Cut the process off a little closer to the source.
So are Type O’s statistically less diagnosed with lupus compared to A,B, AB? And would hydroxychloriquin be more effective on the other types? American breakdown of types was 40% A, 40% O, 15% AB and 5% AB. However that’s a national genotype profile. Cultural clusters concentrates blood groupings. Will the mortality hotspots show these predilections?
So is autopsy showing pulmonary thrombosis? This would lead to an increased v/q ratio and the happy hypoxemia seen?
Remove NY from your data and see the difference.
Are you able to share how your hospital is treating your patients and/or the typical patient risk factors (high blood pressure, overweight, older, etc.) of people being admitted ?
We are starting to see studies that show some therapeuticals are somewhat working but I don’t hear any optimism in your voice when you discuss what you are seeing first hand.
Here in Cleveland, OH the last I heard was our hospitals were 40% empty and they were restarting elective surgeries soon.
Thanks for such insightful video which give us learning and alertness.
If NO availability is required, are there any studies on men who are on daily doses of ED medications?
Due to how viagra works many on ED meds are resistant to covid19’s effects
That’s a good question, as It’s been understood for a long time that sildenafil (viagra) and other 5′-PDE inhibitors can attenuate inflammation and oxidant stress.
makes me wonder if so, does it have anything to do with why more males than females r afflicted w/ covid-19
Thank you, Doc, for another great video! I sincerely appreciate your clear-cut analysis of this virus in a straightforward, understandable language.
Great videos Dr. Seheult!!! Does being on warfarin sodium (to maintain an INR of 2.5 – 3.5) show any correlation with CoVID-19 outcomes? [I had my aortic valve replaced with a mechanical valve 6.5 years ago.]
So is being on lisinopril (and simvastatin) a good thing or not
Yes, as it turns out. Although sadly the conditions that cause a need for it to be prescribed increase the vulnerability of the patient to severe outcomes from covid-19.
@Hermes Agoraeus
Yes it is a good thing or not. Interesting.
Yes, based on previous updates discussing the benefits of “-prils” and “-statins”.
What do you think of the new CDC time based return to work guidelines?
Great information – thank you…
Thank you for your public health service! Connecting the dots helps understand this virus infection! Sincere gratitude! 🙏♥️
Medcram what about if the destruction of endothelial cells leads to exposure of the subendothelial collagen and tissue factor? So coagulation occurs due to both increased vWF and exposure of SEC.
Would not be at all surprising if that was also occuring
Good point!
Too much ROS ?
Try high-dose vitamin C in the following way: ½ teaspoon (2 g) every 30 minutes orally BEFORE emergency status.
I know I am taking more vitamin C as a preventative strategy. Ester C and liposomal C. Plus eating foods high in C like red bell peppers, citrus peels, etc.
What’s the molar concentration
How long you have been doing this??
I am interested in intravenous vitamine C . Not a lot of recent reports !
I hope that this is being shared with experts around the world, including the UK, where we have a very high death rate.
They have closed discussion boards where the free and open sharing of any information is not just encouraged but much needed.
I’m not in the medical profession but have been following these videos for weeks. I’m so grateful for these videos. I’m getting a little lost, so I think I’ll start using some of my extra free time to do some studying so I can make better sense of this. Thanks again.
This is awesome! We’re always welcoming new minds to the study of medicine. Please don’t hesitate to ask questions. I’m so excited for you.
Go for it!
Learning is great mental pleasure and Dr Seheult is one helluva teacher.
Excellent content, as always
Aging is associeted with vWf, CCB’s regulate them?
My husband’s doctor is recommending 1 baby aspirin a day for potential Covid 19 clotting if you get the virus.. Not for my husband as he is on blood thinners. Is this a good idea, as it could lower fever, which helps kill the virus?
A G https://www.facebook.com/789322709/posts/10158302689087710/?sfnsn=mo&d=n&vh=i
Check this post of a Doctor in Sri Lanka. Patients with Covid 19 are treated with Hydroxychloroquin. He also mentions baby aspirins.
He talked about that in the Live Stream a few days ago
A baby aspirin would not significantly lower fever, but it could reduce the risk of a blood clot from platelets. Other supplements that might help are the natural forms of Vitamin E (gamma tocopherol and delta and gamma tocotrienols), and fish oil.
Does the Rhesus factor have any bearing with blood types?
The Rh System is a completely different set of antigens.
Another excellent presentation.
Are other practitioners following your presentations and brain-storming with you?
Is it possible to transfuse a patient with benign ACE2 binding receptors. This would encourage the Virus to bind to a Non Viable Cell and thus do nothing except it would capture the virus preventing infection of other cells.
Hi Doctor, I was just curious if you looked into that cocktail adjunct I recommended in the other video. Citrulline, a-Kg, and high dose Vit C. All seem to take pathways that bypass certain processes the virus takes and support endothelial function and REDOX to a very high level. Any thoughts?
A G Yeah, it seems to be the case. I’ve been researching this since February and came to that cocktail conclusion by the pathways this virus seems to take itself. I found it ironic that it was already part of supplement stacks that weightlifters were using. This latest video throws a little bit of a wrench in it but I think the VWF/ADAMTS13 hypothesis may be incorrect. The pathway of protection discussed by ADAMTS13 would by consequence induce VEGF which would be a negative for COVID and ironically VEGF is already shown to be elevated in COVID patients. If VEGF is considered a negative within COVID by inducing vascular permeability than that would blow the whole Nitric Oxide theory out of the water. So, I would really like for the doctor to respond to be honest. Dots seemed to line up initially, by what he was explaining, but now are crossing unfortunately. I may be wrong but it appears that way. But who knows, maybe VEGF may actually be protective in the COVID version of ARDS. Nicotine, which also upregulates VEGF has been shown to treat women with preeclampsia. A topic the doctor previously discussed. So hypothetically the protective effect of nicotine studies seem to be showing could be explained by VEGF. Since maybe the COVID version of ARDS is, in fact different, NO may be the key. But still doesn’t explain the co-morbidities
I know there may be confounding factors, but from what I have researched, body builders, weightlifters who regularly take AAKG and Citrulline have been having very mild cases of covid-19
Does anyone know how I can safely wash my toothbrush?
I have a plaque problem
So I have to brush my teeth
But I don’t want to stick a brush full of covid in my mouth
… i comb my hair i brush my teeth
Plastic with nylon bristles can be disinfected in a weak chlorine bleach solution or hydrogen peroxide. Rinse before using.
My Grandmother swore by Baking Soda and water once a day. My Mom does it to. Clean healthy mouth, no plaque. I think I will try it, since you brought it up.
Majority of blacks and Hispanics are blood group o
More we know about the origins of this virus and how it works the more interesting hypothesis can be considered. I just wonder if aside of “gain of function” studies that lead to creation of this virus aside of boosting transmissivity were also about improving and targeting gains in specific groups mortality. I hope to see some more studies related to insertion of foreign RNA groups into cov2. This is also interesting to know (if true) if it was done during initial development and studies in the US or after they were outsourced to China.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797993/
Lol
Nutjob
I’M screwed, type A blood and 3 underling conditions. I’m staying home. 😂
good luck cathie, i’m over 60, diabetic, with 3 or 4 more co-morbidities.
look for small de-stressors, like enjoying pretty sunsets when they occur.
@Lost Hero wait, your supposed to breathe? Who knew?
@A G Certainly more helpful than spouting homeopathic advice, giving people a false sense of security…
Under the bed with hepa isolated air supply , MRES and RO water tap . I haven’t sorted out your waste management yet. Give me a few more minutes .
@Lost Hero yeah and all blood dries up in vitro (in a glass tray). Annoloki is the quack the person 2 comments above was warning about.
Showing the # of cases per million seems useless when you see the # of tests per million, we score super low on testing hence our # of cases showing + cases would be low as well
How fast you gentleman are making progress….outstanding.
@texasdee slinglead @texasdee Nooo! I already trashed out my body!
@Amidamaru I’m with you.
Humans are smart af and even more resilient.
At this rate I’m expecting the key to immortality next month .
Crises either make or break humanity. It looks like it pushing our limits to the wall and we are breaking or at least trying to break the wall. People love to bash humans (ironically) but we are a wonderful species.
It’s why we need money thrown at STEM cores.
I’m starting to question how much social distancing slows the spread. Why does countries like Italy and Spain with strict stay at home rules seem to be doing worse? States like New York and Michigan have many more deaths than states that did not have any stay at home orders. Please explain.
Because in Italy & Spain it swept through the nursing homes & retirement homes like fire. And the staff of those homes caught it there, took it home & spread it. This why in some countries like the UK there has been attacks on doctors, nurses & medical staff.
I think you are confusing cause and effect. It takes two weeks for a mitigation to show improvement. So there will be decrease in cases two weeks after implementing a restriction, then several days later a drop in hospitalizations and last, then a drop in death.
@presde34 good news!
You must have an intelligent governor.
Social distancing worked in michigan. The cases have fallen significantly and people are starting to recover.
Because places like Italy and New York locked down long after the virus had circulated throughout communities.
Do not trust Chinese data or conclusions.
I dont get it…how were so many people getting infected over the past two or three weeks? I can understand a few but with social distancing and stay at home in place for going on 7 weeks, how are so many new cases appearing now? Also, the people appearing and being counted positive are, i would assume, a small percentage of those actually infected over the past three week (assuming a max 3 week covid incubation)
good point tho…. is this germ already laying dormant within us like a retro-virus IDK who can say? On the other hand if you single out one population, say New York … you can see a great reduction in cases–And in N.Y.C. the people are, generally minding their social distancing quite well.’
Many people are not being careful & following the rules
J Yee your not going to get an answer to that question. We must just assume that shut downs and stay at home orders work without question. Even though if one looks at the numbers of infections and deaths and compare where it makes one wonder.
How will the use of dabigatran effect this mechanism? Is there any experience?
Whoa. Love this detective research work! Well done! very convincing.
Another excellent video. Thanks from a UK doctor.
Same praise coming a swiss medical student!
VitD helps if you’re deficient but I don’t think that it’s the magic bullet
High VitD needed to beat SARS-CoV-2.
Magnificent work! Thank you!
Is COVID-19 transmissible through receiving blood products? If so, shouldn’t the American Red Cross be testing every blood donation that they receive for COVID-19 so that they are not transmitting COVID-19 to those people who will receive their blood products? My current understanding is that the American Red Cross is not testing blood products for COVID-19. Instead, the American Red Cross is apparently depending upon taking the vitals of blood donors and asking them a few questions in order to attempt to filter out people who have COVID-19 from donating blood. However since a lot of people with COVID-19 are asymptomatic these measures are obviously of limited effectiveness.
@Jake Aurod In a pervious video, it discusses how the virus loads T Cells with RNA in a similar way HIV did with DNA. Not a field I’m familiar at all with but something to point out.
@William Warren I do recall a MedCram update where he said he wasn’t sure if viremia was present. Perhaps the immune cells primarily attack the virus by entering the lymphatic system or interstitial spaces between cells and organs? Some of the cells that COVID binds to are immune cells, and while that cell is not infected per se, it is affected and may not function properly but won’t allow replication of the virus. I think he’s mentioned all this in previous update videos.
@Michele Curlee I agree that it is not a good time to need a blood product. However, people undergoing through chemotherapy frequently must get platelets to avoid internal bleeding. Unfortunately, I have heard from many sources that people fighting cancer are especially vulnerable to dying from COVID-19.
It is too bad that testing for COVID-19 has become such a political issue. The President has a long-standing aversion to accelerating testing and now that Governors of 30 states and CEOs of many companies who have been told by their constituents and investors to “reopen as soon as possible no matter what”, I worry that there will be tremendous pressure on these officials to actively cover up the true extent of COVID-19’s spread.
@annoloki Thank you for your reply. However, it does not make sense to me. If COVID-19 gets into your cells – basically any cell it can get into, I think it starts reproducing itself – which is the essence of what “having a virus” is. Also, if COVID-19 does not exist into the blood stream, then what is the point of creating a vaccine? Isn’t the point of the vaccine to help the body to create antibodies – in the blood – that will recognize and adhere to copies of the virus?
I don’t think it is, if any virus particles even make it into the blood supply, it won’t be long before they are taken up into cells. These cells could be included in donated blood, and they may contain viral RNA for a short time (until it is broken down, as all RNA already has to be) but evidence shows these cells don’t appear to be replicating the virus
you mentions the Extra Electrons, last time but you keep missing the IMPORTANCE of the EXTRA ELECTRONs, Grounding /Earthing increases Electron Uptake SUBSTANTIALLY!!!!! Free electrons have unassociated electrons to donate, these Free electrons donate to a ROS to Neutralize it, as a Positive ion and a Negative ion cancel each other out, Neutralized. Talk more about the Electrons as this is Very Important, you keep missing it. This is a Electron Deficiency!!!!!
Dr. Seheult, I appreciate your work so much. You are a leader for all Americans and for all interested in science.
…and for other countries too 🙂 I agree, he’s an inspiration.
Thank you.
Are u using convalescent plasma and if you do how well is it working?
I am awaiting an answer too !
Thanks again.
What abt vit D and VWF? https://www.researchgate.net/publication/312247878_Effect_of_Vitamin_D_Status_on_Von_Willebrand_Factor_and_ADAMTS13_in_Diabetic_Patients_on_Chronic_Hemodialysis
There are ACE2 receptors on endothelial cells, the virus attacking those cells could also be part of the release of VWF?
Yes
It is attacking all ACE2 receptors.
Looks like I will need to start earlier as I do not know what Ace or ace 2 are.
ACE = Angiotensin Converting Enzyme. It affects the blood vessels to control constriction, among other things. ACE Inhibitors are a class of medicines that are used to reduce blood pressure by dilating blood vessels, IIRC.
Coronavirus Pandemic Update 37: The ACE-2 Receptor – The Doorway to COVID-19 (ACE Inhibitors & ARBs)
https://www.youtube.com/watch?v=1vZDVbqRhyM&t=498s
Yep. For the first ten minutes I’m like “ wut he said “. D diners? WVF. WTF.
Mollie Wolfe the inexpensive drug HCQ….
Makes me wonder why they removed 60.
I wonder what he explains in it.
Good to see that someone remembered the cram, salty cram….
A pity he didn’t call it MedLembas.
I am a youtube-r from China. Thank your expertise, praying for the American people to get through this virus soon!
We are globally in this fight. Is there other hospital aquired infections that are popping out of this pandemic. There are reports of Hantavirus etc….
China Bill stay safe
Stay safe and well Bil
God bless the citizens of China.
China Bill,
Thank you for your kind wishes.
Keep safe also.
The reduction in NO, does that present as erectile dysfunction in male Covid19 patients at all? 🤔
It could do, a clot can block any blood vessel it gets stuck in. Look out for any numbness caused by lack of blood flow, this has been seen in people’s legs, causing strokes etc. I don’t think it’s being tested for though.
Roger is the Sherlock Holmes of Covid-19. Fascinating and thank YOU!
Fantastic video as always, thanks for educating all of us even those not in the medical field; please keep it up! One suggestion that would be great is to see closed caption enabled, if possible.
Enabled, thanks!!!
A New York doctor posted this video over a month ago.
https://youtu.be/0yrCjsaZKg8
Cycling may be due to the weekend, but not conclusively due to weekend reporting. Could be a lag in reporting or a lag in developing symptoms or a combination of things.
Thank you very much for all of the wonderful content. I just love learning from your posts.
Thank you for your feedback
Thank you 🙏
I live in Riverside County. Thanks for helping here 🙏🏼♥️
Yes, I believe in science. Thank you
🤣🤣🤣
Will having high mean platelet volume contribute to severity of clotting in covid19 patients despite a normal platelet count?
Assume yes
Dylan Stetson probably?
Dylan Stetson good question
So 9 % of subjects were AB and that 9% died?
@3ceasurirele Thank you.Had minor freak out there as an AB+
9% of the number of deaths, not of patients….. which means much less
750k subs! 👍🏼
awesome work ! congrats. Glad to see evidence based medicine on youtube! You have inspired me to create my own channel with descriptions of medical procedures. check it out!
Nice work on the cricothyrotomy.
I found that breathing 2% hydrogen gas began to reverse the loss of taste and burning feeling behind the sternum. Could this be because the extra hydrogen was finding superoxides and recombining into H2O2?
@Sandeep Sharma If you are taking zinc, you must also take a zinc ionophore with it to transport the zinc into your cells. I take EGCg, an extract from green tea, with 30-50mg balanced zinc/day (zinc l-methionine with copper). I also take an ARB (angiotensin receptor blocker): CoQ10 (another one other people are using is quercetin, but I haven’t tried it). If you want to try natural remedies, see my links on this comment to studies showing that barley is effective for inhibiting Covid19 infection and blood clots. Garlic is good for thinning blood and lowering blood pressure naturally; it is an ARB that reduces the number of angiotensin receptors (don’t know if that’s a good thing or not). Licorice kills the virus and thins the blood, but it raises blood pressure, so use only under a doctor’s care. I also highly recommend mustard plasters and mustard foot baths (dry mustard is full of volatile oils that penetrate tissue; it is antiviral, antimicrobial, and antioxidant; and it will raise internal body temperature and bring out a sweat, which stimulates the immune system; therefore, do not use during fever, but it is excellent if your bp and temp are low, or lower than normal).
@Charizard215 I’m not a medical professional. I’m on Day 57 of this illness. You should ask the doctor about your chest pains and he/she will know what kinds of tests to order. Home treatment for pulmonary (lung) symptoms that work for me are mustard plasters up to 4x/day over the most painful part of the chest or ribs (make sure to oil your skin before applying the plaster). I am still using them in the mornings to clear mucus.
I am having the middle chest heavyness and pain from pass 40 days . Its pain which is constant I am also feeling to tried and exhausted. I tried nebuliser with hydro peroxide with concentration of 3 % but it aggravated my symptoms I started getting wheezing sound from my chest .I immediately stop it and at least the wheezing sound has disappeared. I believe such thing aggravated it more. So please avoid. I am being to feel that I am infected because beside getting tried and only middle chest heavyness and pain . I find breathing difficulty however my oxygen saturation level are always around 98 but surprisingly my blood pressure has almost become normal which use to be very high that too when I have stop getting my blood pressure pills. Also my heart beat is always around 60 and sometimes in night it fall around 52. This all changes really alarm me. I am taking all vitaman bills zinc supplementation, Indian herb to control inflammation and blood clot medicine as precaution. Hoping it work but evidently it’s not working because my symptoms never mitigate.
Must add that as well as being a natural serine protease inhibitor (COVID-19 has a serine rather than glycine at pos. 723, https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793(96)00940-4) , BARLEY also inhibits coagulation factors. (https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793(96)00940-4). Barley water has been used for centuries to treat illness, and it is working well for me. Easy to make at home, pearl barley is cheap and widely available. I hope you look into this.
Burning behind the sternum? That’s in the middle of the chest, right? I just started getting that about two days ago. Along with some aching right over my upper left pectoral. What does that mean? I want to go to the doctor tomorrow, so I want to know what I’m in for.
I’m no biologist or doctor, but I keep up with these videos, so I hope you can excuse any ignorance.
I’m type O ,👍
Another good video. Now need to watch it xD
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Kieran H good call
Thank you
Thank you for your support